Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppt
Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
... extracellular matrix and proteinase genes are regulated by TNF-induced MEK/ERK signallingWe further analysed the lists of genes that were induced by TNF using specific gene ontologies. Analysis of the ... activity of NFB and Sox9 in chondrocytes [10,12]. TNF-induced NFB DNA binding in immortalized chondrocytes is reduced by inhibition of MEK1/2 signalling [10]. TNF may thereforeregulate the expression ... significantly cate-gorized by the molecular function of their protein products intocategories that included hyaluronic acid binding activity(including Agc1 and Hapln1) and proteinase activity (includingMmp-9...
- 14
- 574
- 0
Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... effects of diac-erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsinK. Moreover, we sought to gain new insight into the effects of the ... μg/mL).Effect of diacerein/rhein on intracellular signalling pathwaysTo gain insight into the mechanisms of these drugs on the OAsubchondral bone osteoblasts, we further studied the effect of the therapeutic ... cathepsin KSince MMP-13 and cathepsin K are produced by the murinecell line Raw 264.7, proteins not recognized by the commer-cially available ELISAs, determinations were performed usingactivity...
- 10
- 536
- 0
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... regula-tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... responseduring acclimatization to hypoxia.ResultsEffects of hypoxia on HO-1 and HO-2 expression in human cell linesWe initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in...
- 12
- 621
- 0
Báo cáo y học: "Considerations for the inclusion of 2x mammalian genomes in phylogenetic analyses" ppsx
... number of Figure 2. Increase in gene number through evolutionary time for all lineages (blue lines) in the latest Ensembl version (version 59). The red line indicates the lineage leading to the ... duplications at the root of the eutherian mammals increases by only 4.5%. Moreover, the total number of supported duplications is reduced by only 10%. is suggests that the addition of low-coverage ... that the ‘addition of new placental mammal genomes in the gene trees increases the probability of finding a gene misplaced in the tree.’ We had anticipated that possibility in our study (page...
- 4
- 338
- 0
Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
... luciferin by luciferase in the presence of extremely low levels of ATP. Aftercollecting the chondrocytes by scraping, cells were centri-fuged for 10 min at 500 × g in the cold. Chondrocytes pelletswere ... production in chondrocytes Chondrocyte activity was measured by the production of gly-cosaminoglycan (GAG) from cultured chondrocytes. Chondrocytes were cultured under either normoxic or hypoxicconditions ... radicals) may induce the expression of HIF-1α in articular chondrocytes. IL-1 has beenshown both to inhibit chondrocyte anabolic activity, including the down-regulation of proteoglycan synthesis,...
- 11
- 385
- 0
Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"
... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... supplemen-tation. The increasing number of the elderly is ex-tending the progressive age-related decline in BMD, thereby increasing the need for additional supple-mental calcium and vitamin D3 [5]. There ... re-viewed in the meta-analysis cited above. As for the unusual finding of the increased BMD levels found in the three study groups, the superiority of Plan 3 over Plan 1 suggests that the physical...
- 12
- 663
- 0
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... presence of CYP3A5*1 allele does not predict the amount of CYP3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP3A5 protein, dual ... therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in...
- 7
- 785
- 0
Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... Immunology and Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding address: Prof. C.H. Cho, Department of Pharmacology, The University of ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend the therapeutic application of CY in cancer...
- 6
- 655
- 0
Báo cáo y học: "Update on the treatment of ocular toxoplasmosis"
... by Rothova et al was 250mg a day or 500mg every other day and therapy was associated with pyrimethamine 100mg on the first day that was fol-lowed by 50mg a day. Prophylaxy of recurrence of ... survey of the opinion of oph-thalmic specialists in uveitis was performed recently by Gary Holland. [3] The reasons that were commonly accepted to introduce a therapy were the following: a) the ... in the therapy of ocular toxoplasmosis. But the out-come was measured 4 weeks after initiation of ther-apy. Dihydrofolate reductase inhibitors (DHFR) have shown their efficacy in vivo in the...
- 3
- 522
- 0
Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngbáo cáo tuần sinh hoạt tập thể đầu năm họcmẫu báo cáo y tế học đườngBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015