Báo cáo y học: "Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6" doc

... K:Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leuko-cyte infiltration and synovitis in rabbit joints. LymphokineCytokine ... separately with cell-permeable inhibitors of MAP kinase/ERKkinase-1/2 (PD98059), p38 (SB203580), protein kinase C (calphostin C), and tyrosine kinase (genistein),followed by the addition of IL-17 ... anincrease in TSG-6 after stimulation of SFCs with IL-17.TSG-6 is a hyaluronan-binding protein found in the syn-ovial fluids of arthritis patients. TSG-6 has a significanthomology to the hyaluronan-binding...

Báo cáo y học: "Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score" potx

... achieved by 69% of patients at the end of the first year, ACR50 by 59%,and ACR70 by 47%. To allow comparison of changes in com-posite scores in individuals with ACR responses, we grouped patients& apos; ... M, Smolen JS:Benefit of very early referral and very early therapy with dis-ease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford) 2004, 43:906-914.10. ... and immediate assessment of disease activity by including only variables that are available by physical examination and patient questioning at the time of interaction with the patient. Therapeutic...

Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx

... of the arthritic inflammation was induced 14 days afterintra-articular injection (designated day 0) by intravenousinjection of 200 µg PG-PS. This resulted in monoarticulararthritis involving ... changes in gene expression were calculated by divid-ing the mean intensity signal from all the individual SCW-injected rats included in each group by the mean intensitysignal from the corresponding ... shown in previous studies[10,11], analysis of gene expression profiles by processingwhole homogenized joints can provide useful informationabout dysregulated genes, not only in synoviocytes...

Báo cáo y học: "Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis" pot

... described by Nanakumar and coworkers [12], scoring of animals was done blindly using a scoring system based on thenumber of inflamed joints in each paw, inflammation beingdefined by swelling and ... established in mice by immunizing them with meth-ylated bovine serum albumin (mBSA) in CFA with or withoutan arthritogenic infectious agent at days 0 and 7, followed by intra-articular injection of ... β1/β2 integrins, P-selectin is the predom-inant adhesion molecule, mediating monocyte binding toinflamed synovial venules [23]. Similarly, increased cellularinfiltration and increased expression...

Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps

... cartilage with mineralized bone tissue.Equivalently, chondrogenic cultures induced by BMPsshowed high expression of genes associated with chondro-cyte hypertrophy, including collagen type (COL) ... TGF-βsuperfamily. BMPs are a group of secreted polypeptides with pleiotropic roles in many different cell types and were originallyidentified by their ability to induce endochondral bone forma-tion in ... calcifying zone of cartilage could be clearly separated by the proximity of the cells to the joint space and the bonerespectively, alignment of the chondrocytes along the arcades of Benninghoff...

Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx

... findings extended those of other groups (working in MS and SLE) by including patients with RA and IDDM,and by offering direct comparisons between them. Thesimilar gene expression findings in ... forclinically distinct disorders within the autoimmune category.Consistent with this hypothesis, we have found thatclustering analyses can be used to separate patients with early RA of 2 years’ ... approachwere largely in oncology, many new reports are emerging in other fields including infectious diseasesand pharmacology, and applications in autoimmunity have been recently reported by our group...

Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps

... represented by genes encoding interleukins, chemokine receptors and ligands,and by those involved in antigen recognition and processing.Keywords: DNA expression array, differential gene expression, inflammation, ... detected and ana-lyzed in this study. The development of new proteomicsassays, and the synthesis of existing knowledge in cellularsignaling pathways with information provided by gene expression studies, ... donor lymphocytes, only veryfew cells were found in joints during the first week of transfer, and a second cell transfer was needed to inducea significant influx of lymphocytes into the joints...

Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc

... overexpressed at baseline in poor responders are induced by several cytokines in FLSs,thereby suggesting a role for these cytokines in the resistanceto TNF blockade in RA.ANOVA: analysis of variance; ... biological action of a cytokine than raw evaluation of itssynovial concentration. By indicating that a representative panel of genes overex-pressed in poor responders are induced in FLSs by TNF-α, IL-1β, ... Lauwerys BR: Identification of distinct gene expression profiles in the synovium of patients with systemiclupus erythematosus. Arthritis Rheum 2007, 56:1579-1588.29. Lindberg J, af Klint E, Catrina...

Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx

... [13].There is increasing evidence that SFs are key players in thepathogenesis of RA by invading and eroding hyaline cartilage.SFs, activated locally, produce a variety of cytokines, chemok-ines and ... explained either by inhibition of its expression within the synovium or by upregula-tion of it by factors during in vitro growth of fibroblasts.Figure 6Gene expression of synovial fibroblast ... rather resulted from enzymerelease by cells (including infiltrating inflammatory cells) withinthe joints.Competing interestsThe authors declare that they have no competing interests.Authors'...

Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt

... BCL-2 (Figure 2), may enhancetheir binding to BCL-2, thereby inhibiting the anti-apop-totic function. Thus, we analyzed the BCL-2 protein expression level by flow cytometry in Molt-4 cells at ... theheterogeneity of T-cell malignancies during apoptosis induced by BCL11B downregulation [22], so it remainsto be determined whether apoptosis induced by BCL11Bdownregulation in some cases with T-ALL involves ... mitochondrial BCL-2 family genes (the BH3-onlydomain proteins BIK and BNIP3) enhanced their bind-ing to BCL-2, with a reduction in the anti-apoptoticgene BCL2L1, thereby inhibiting the anti-apoptotic...

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Từ khóa: Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoại Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDE Phối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọ Phát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninh Trả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chế Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2 Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘI HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ