... IRS-2, insulin receptor substrate-2; PUFA, polyunsaturated fatty acid; SCAP, sterolregulatory element-binding protein cleavage-activating protein; SREBP, sterol regulatory element-binding protein.616 ... causinglipotoxicity in various tissues and organs. It has beenreported that SREBP-1c is involved in hepatosteatosis and pancreatic b-cell dysfunction [25,26].Insulin resistance in liver and ... sterol regulatory element-binding protein cleavageactivating protein ⁄ sterol regulatory element-bindingprotein pathway. Mol Endocrinol 15, 1817–1828.13 Yang YA, Morin PJ, Han WF, Chen T, Bornman...