... receptors.All-trans-RA inhibits the DNA binding activity of NFAT To understand the molecular m echanism of RA-inducedinhibition of NFAT activity, we investigated whether the DNA-binding activity ... homeostasis of lymphocytes, and the main-tenance of peripheral tolerance. Retinoids, vitamin A and itsnatural and synthetic derivatives, regulate a wide array of biological processes, includin ... T-cells(NFAT), which is an important transactivator of the FasL promoter. The analysis of reporter constructs containing the FasL promoter and wild-type or mutant NFAT binding-sites indicated that all-trans-RA...