Báo cáo khoa học: Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers pot

... article.Modulating amyloid-b aggregation M. Nitz et al.1674 FEBS Journal 275 (2008) 1663–1674 ª 2008 The Authors Journal compilation ª 2008 FEBS Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers Mark ... identiﬁed inositol stereoisomers as exhibiting stereospeciﬁcinhibition of A b aggregation and toxicity in vitro and in vivo. We reporthere the effects of inosose versus inositol stereoisomers on ... chiro -inosose scyllo-inositolscyllo -inosose epi-inositolepi-2 -inosose allo-inositol allo-3 -inosose Fig. 2. Determination of the secondarystructure of Ab42 in the presence and absence of inosose...

Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx

... mediated by the ANT in maximallypolarized (forward mode of both ANT and ATPase) and maximally depolarized (reverse mode of bothANT and ATPase) mitochondria.Flux control coefﬁcients of ANT and F0F1-ATPsynthase ... difference of DWm (termedDelta phi) before and after the addition of ADP(2 mm) to WT and CYPD KO mitochondria, and cal-culated on the basis of steady-state titration data by catr and olgm. ... WT and CYPD KO mitochondria by substrate deprivation and rotenone, and subsequently energized by the exogenous addition of 2 mM ATP(with 1 mM total MgCl2in the buffer), as a function of...

Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

... action of EPA and DHA (Eur. J. Biochem. 271) 4465 Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAsInduction of cyclin D1 is one of the e arliest effects of mitogenic ... Anti-mitogenic action of EPA and DHA (Eur. J. Biochem. 271) 4473 Modulation of cyclin D1 and early growth response factor-1 geneexpression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 ... binding of the transcription factors Egr-1, as for NF-jBandEts-1,probably by reducing MAPK activity [18]. As NF-jB, Ets-1 and Egr-1 are substrates of MAPK [12,43,44], the inhibition of MAPK by the...

Báo cáo khoa học: Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand pptx

... 3). Modulation of the interaction of AhR-LBD withCBP by AhR ligandsAhR activation is at least partially mediated by therecruitment of CBP to the target promoters [29]. Toassess the inﬂuence of ... receptor:implications for prevention of dioxin toxicity. Mol Phar-macol 56, 784–790.51 Edwards DP (2000) The role of coactivators and core-pressors in the biology and mechanism of action of steroid hormone ... addition of 1 lm of a typical AhR ligand, b-naphthoﬂavone(BNF), and increasing concentrations of carbaryl resul-ted in a typical inhibition curve, with an apparent IC50 of 256.3 ± 38.2 lm (Fig. 2 and...

Báo cáo khoa học: Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes potx

... Ricerche, Genova, Italy3 Heisenberg Group of Biophysics and Molecular Plant Biology, Institute for Biochemistry and Biology, University of Potsdam, Potsdam-Golm, GermanyIntroductionPlants ... (nPKC; d, h, g and e), which lackCa2+-binding sites, and atypical PKCs (aPKC; f, k ⁄ i and l), which are Ca2+-insensitive and are not acti-vated by phorbol esters [37]. Both cPKCs and nPKCsare ... participate in the regulation of KAT1 channel activity to respond to variousTable 1. Percentage of current inhibition by PKC activation. Currentinhibition of KAT1 and its mutants by PKC activation at...

Báo cáo khoa học: Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b pptx

... Modulation of Ca2+entry by TRPM4bFEBS Journal 274 (2007) 704–713 ª 2006 The Authors Journal compilation ª 2006 FEBS 713 Modulation of Ca2+entry and plasma membrane potential by human TRPM4bRalf ... indicated by arrow; solid lines) or untreated(dashed lines). (B) Quantitative analysis of the amplitude of Ca2+released by ionomycin (left) and the amplitude of Ca2+entry afterreaddition of Ca2+(right). ... demonstrated by confocal ﬂuorescence microscopy. The functionality and plasma membranelocalization of overexpressed TRPM4b was conﬁrmed by induction of Ca2+-dependent inward and outward currents...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... solu-tion of ThT and the ﬂuorescence intensity of the solu-tion was measured at 482 nm. Figure 4A shows thekinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... rate of a-synuclein aggregation even in the absence of com-ponents of mitochondrial complex I. In contrast to the effect of dopamineon the aggregation of a-synuclein alone, in the presence of ... compilation ª 2011 FEBS Modulation of a-synuclein aggregation by dopamine in thepresence of MPTP and its metabolitePrashant N. Jethva, Jay R. Kardani and Ipsita RoyDepartment of Biotechnology, National...

Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx

... system of shuttle vec-tors and yeast host strains designed for efﬁcient manip-ulation of DNA in Saccharomyces cerevisiae. Genetics122, 19–27.Sterol homeostasis modulation by Ste20p and Cla4p ... Deletion of CLA4 results in higher amounts of SE. (A) Quan-tiﬁcation of SE in cell polarity mutants. Cells of the indicated strainswere grown to stationary phase and then lipids were extracted and separated ... S,Daum G et al. (1999) Electrospray ionization tandemmass spectrometry (ESI-MS ⁄ MS) analysis of the lipidSterol homeostasis modulation by Ste20p and Cla4p M. Lin et al.7262 FEBS Journal 276...

Tài liệu Báo cáo khoa học: Modulation of the enzymatic efﬁciency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx

... arrangement.Design and construction of C266, G267 and L268single and double FNR mutantsFive single mutants of C266, G267 and L268 and adouble mutant of C266 and L268 were successfullyconstructed and conﬁrmed ... Role of methionine56 in the control of the oxidation–reduction potentials of the Clostridium beijerinckii ﬂavodoxin: effects of substitutions by aliphatic amino acids and evidence fora role of ... exception of G267V, was rela-tively unchanged, as shown by the fact that mutationsin FNR did not alter the near-UV band of theCD spectra. A small perturbation of isoalloxazine wasdetected by CD and...

Tài liệu Báo cáo khoa học: Modulation of oat arginine decarboxylase gene expression and genome organization in transgenic Trypanosoma cruzi epimastigotes docx

... digestion of the DNA samples.On the other hand, the absence of a second hybridiza-tion band in lane 1 might be the result of insufﬁcientsensitivity of our assay. Rehybridization of the mem-brane ... thetime-course modulation of foreign gene expression and to investigate whether this modulation can beexplained by the concomitant changes occurring in theparasite genome organization.Results and DiscussionExpression ... this promoter region of pRIBOTEX and related vectors induces the transcrip-tion of genes cloned downstream of the promoter and their chromosomal integration [19]. After 48 h of transfection, geneticin...

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