Báo cáo khoa học: Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers pot

... article. Modulating amyloid-b aggregation M. Nitz et al. 1674 FEBS Journal 275 (2008) 1663–1674 ª 2008 The Authors Journal compilation ª 2008 FEBS Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers Mark ... identified inositol stereoisomers as exhibiting stereospecific inhibition of A b aggregation and toxicity in vitro and in vivo. We re...

Ngày tải lên: 16/03/2014, 06:20

... mediated by the ANT in maximally polarized (forward mode of both ANT and ATPase) and maximally depolarized (reverse mode of both ANT and ATPase) mitochondria. Flux control coefficients of ANT and F 0 F 1 -ATP synthase ... difference of DWm (termed Delta phi) before and after the addition of ADP (2 mm) to WT and CYPD KO mitochondria, and cal- culated on the basis of...

Ngày tải lên: 14/02/2014, 19:20

... action of EPA and DHA (Eur. J. Biochem. 271) 4465 Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the e arliest effects of mitogenic ... Anti-mitogenic action of EPA and DHA (Eur. J. Biochem. 271) 4473 Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-...

Ngày tải lên: 19/02/2014, 16:20

... 3). Modulation of the interaction of AhR-LBD with CBP by AhR ligands AhR activation is at least partially mediated by the recruitment of CBP to the target promoters [29]. To assess the influence of ... receptor: implications for prevention of dioxin toxicity. Mol Phar- macol 56, 784–790. 51 Edwards DP (2000) The role of coactivators and core- pressors in the biology and...

Ngày tải lên: 16/03/2014, 10:20

... Ricerche, Genova, Italy 3 Heisenberg Group of Biophysics and Molecular Plant Biology, Institute for Biochemistry and Biology, University of Potsdam, Potsdam- Golm, Germany Introduction Plants ... (nPKC; d, h, g and e), which lack Ca 2+ -binding sites, and atypical PKCs (aPKC; f, k ⁄ i and l), which are Ca 2+ -insensitive and are not acti- vated by phorbol esters [37]. Both c...

Ngày tải lên: 22/03/2014, 21:21

... Modulation of Ca 2+ entry by TRPM4b FEBS Journal 274 (2007) 704–713 ª 2006 The Authors Journal compilation ª 2006 FEBS 713 Modulation of Ca 2+ entry and plasma membrane potential by human TRPM4b Ralf ... indicated by arrow; solid lines) or untreated (dashed lines). (B) Quantitative analysis of the amplitude of Ca 2+ released by ionomycin (left) and the amplitude of C...

Ngày tải lên: 23/03/2014, 09:21

... solu- tion of ThT and the fluorescence intensity of the solu- tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... rate of a-synuclein aggregation even in the absence of com- ponents of mitochondrial complex I. In contrast to the effect of dopamine on the aggregation of a-...

Ngày tải lên: 14/02/2014, 19:20

... system of shuttle vec- tors and yeast host strains designed for efficient manip- ulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19–27. Sterol homeostasis modulation by Ste20p and Cla4p ... Deletion of CLA4 results in higher amounts of SE. (A) Quan- tification of SE in cell polarity mutants. Cells of the indicated strains were grown to stationary phase and then l...

Ngày tải lên: 18/02/2014, 13:20

... arrangement. Design and construction of C266, G267 and L268 single and double FNR mutants Five single mutants of C266, G267 and L268 and a double mutant of C266 and L268 were successfully constructed and confirmed ... Role of methionine 56 in the control of the oxidation–reduction potentials of the Clostridium beijerinckii flavodoxin: effects of substitutions by al...

Ngày tải lên: 18/02/2014, 17:20

... digestion of the DNA samples. On the other hand, the absence of a second hybridiza- tion band in lane 1 might be the result of insufficient sensitivity of our assay. Rehybridization of the mem- brane ... the time-course modulation of foreign gene expression and to investigate whether this modulation can be explained by the concomitant changes occurring in the parasite genom...

Ngày tải lên: 19/02/2014, 07:20