... arrest and apopto-sis and suppresses cell growth and metastasis, possiblyby silencing these target genes [28,33,37,39–41].miR-124Many studies have shown that mature miR-124 is the most abundant ... notcopy-edited or typeset. Technical support issues arisingfrom supporting information (other than missing files)should be addressed to the authors.F. Sato et al. MicroRNAs and epigeneticsFEBS Journal ... proteins,HDACs 1 and 2, classified as class I HDACs, areimplicated in cell proliferation, apoptosis and chemore-sistance. The expression of HDACs 1 and 2 is elevatedin various cancers [75]. However, the...