... 1465–1470.53. Aoki, M., Ogasawara, M., Matsubara, Y., Narisawa, K.,Nakamura,S.,Itoyama,Y.&Abe,K.(1994)Familialamyo-trophic lateral sclerosis (ALS) in Japan associated with H46Rmutation in Cu/Zn ... black and the residuelabels are underlined.Fig. 3. Tube representation of the family of 30 structures of human reduced native SOD obtained with DYANAcalculations and refined with REMcalculations. ... 6 the active site is shown and compared with that of oxidized human SOD. All the metal ligands are well defined in a single conformation. For all the ligands, the rmsd valuecalculated for all...