tha'y cd su khong ddng nha't ve thu the (cac dudng- trung tam tuang tac vdi lectin), hoac ve thanh phan va kieu lien ket cua thu the vdi cac gdc oligosaccharide va polypeptide cd tren be mat cac chiing vi khuan khac nhau. Chinh vi cd kha nang nhan biet sir sai khac nay ma lectin da trd thanh mot cong cu die luc trong nhan dang va dinh loai vi sinh vat, thay the cho cac phuang phap phan loai phiic tap va tdn kem thudng diing [19, 43].
ft- Tdc dung ten susinh trudng cua vi khudn
Chiing tdi cung da xem xet tac dung ciia lectin tii hemocyte sam len su sinh trudng cua vi khuin. Anh chup trdn hinh 15 cho thay chd' phim lectin (gidng 1-
2) da lie ch^ su sinh trudng cua tu clu trlng Staph, epiedermidis 5-02 nudi cly
trdn dia thach (tuy khdng manh nhu khang sinh), trong khi dich chiet thd (gidng 3- 4) khdng bilu hidn ro tac dung nay. Nguydn nhan cd the do ham lugng thip ciia lectin trong djch chi^t (tuong ddi loang) va lucmg miu sir dung qua nhd.
Hinh 15- Tac dung ciia lectin hemocyte sam len sir sinh trudng ciia vi khuan
Ghi chu: 1,2- CP; 3,4- DC 2; 5- khang sinh oxacillin; 6- ddi chiing (ddm PBS)
Nhu vay, tac dung gay ngung kd't va lie chd' sinh trudng te' bao vi khuin cua lectin hemocyte sam bieu hidn kha nang tham gia vao ca che' midn dich (nhan bid't va lam bat hoat cac vi khuan xam nhap) dang sa khai ciia lectin d loai dpng vat chan ddt cd ngudn gdc rat xa xua nay. Ddng thdi chiing cung tao ra kha nang su dung lectin trong cac nghien ciiu vl midn dich cung nhu iing dung trong thuc td' dinh loai vi khuin, nhit la cac loai cd tim quan trpng vl dich td ddi vdi con ngudi.