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Considering mechanistic data to assess mode of action or human relevance

Considering mechanistic data to assess mode of action or human relevance

Hóa học - Dầu khí

... property of a substance to cause harm – Toxicological, epidemiological study – “Strength” of evidence – Judgment on the reliability of a given data set supporting a toxicological effect • Quality ... of all relevant information supporting conclusions regarding a toxicological effect, including human relevance • Consistency, specificity, biological plausibility • Which critical effects for dose-response? ... to toxicity • E.g., effects on hormones leading to secondary outcome • Toxicity leading to cell death and repair • Physical irritation of chemical precipitates McLaughlin Centre University of Ottawa...
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labor market transitions of involuntary part-time workers how hard is it to get back to full-time jobs

labor market transitions of involuntary part-time workers how hard is it to get back to full-time jobs

Kinh tế

... better target policy To explore this possibility, under objective multinomial probit models with five The Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) of 1996 gives ... income Therefore, departing from existing literature that often uses an individual utility maximization theoretical framework, this dissertation employs the household utility maximization framework ... CPS for 1996 to 2004 Results show that the probability of transitioning into full-time work remains lower than 50% highlighting the difficulty of a worker finding more hours over a one-year period...
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Internet Payment Processing Introduction What is online payment processing? How hard is it ppt

Internet Payment Processing Introduction What is online payment processing? How hard is it ppt

Quản trị kinh doanh

... leverage any existing relationship with your bank by seeing what they can provide for you Online payment processing refers to the purchase of goods and services over the Internet typically using ... implement online payment processing on my website? If you have an existing website that currently displays your products, incorporating online processing may not be too difficult or costly Every online ... you can provide your American customers with the ability to purchase without worrying about exchange rates While there is a definite marketing advantage to this, you should carefully weigh the...
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báo cáo khoa học:

báo cáo khoa học: "Why don’t hospital staff activate the rapid response system (RRS)? How frequently is it needed and can the process be improved?" potx

Báo cáo khoa học

... preventing them from calling for help These barriers may occur between professional groups, within professional groups, or as a result of a group identity existing such as within a ward or specialty ... situation awareness model has three distinct parts: perception, comprehension, and projection Perception Perception of the vital signs of a deteriorating patient typically means that the observations ... These potential solutions will be rated in terms of feasibility, acceptability, cost effectiveness, effectiveness, and sustainability Up to five solutions will be chosen, and be implemented as...
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Báo cáo y học:

Báo cáo y học: "Variability science in intensive care – how relevant is it" docx

Báo cáo khoa học

... testing Hypertension 1999, 33:987-991 La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ: Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality ... heart rate variability is impressive Thus, variability studies may not allow one to disentangle the precise physiological mechanisms that are involved in heart rate variability alterations in the ... electroencephalographic activity during normal sleep [7] However, very little is known regarding how heart rate variability relates to electroencephalographic activity in the ICU patient, and whether...
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Bài giảng môn tiếng anh 7: Unit 4: Set 4: How long is it?

Bài giảng môn tiếng anh 7: Unit 4: Set 4: How long is it?

Tiếng anh

... three: pupils Time frame: Activity 2 Teacher Pupils Introduce the sampleListen and brainstorming sentence by using pictures Introduce the system ofListen and distinguish the English measurement ... Listen and evaluate Teacher make conclusion Do a quick test and evaluate Activity of group one: Working with computer Activity of group two: Time allowed 5 15 10 5 Materials: colour paper, scissor, ... specific dimensions (length, width, height) Then present before the class about their product Activity of group three: Materials: disordered sentences which are written in different piece of papers...
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Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.

Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.

Quản lý dự án

... questions Day - Software Design Prototyping - its benefits Valuable task to address & resolve various requirements & design issues May be a continuation of a prototyping tasks begun during planning ... capability Initial customer installation may begin Node H Node I Day - Definitions & Overview Node A Node B Node C Node D H The software is ready for full deployment or general customer availability ... issues, & outputs from a prototype design B Day - Software Design Correct and improve Reused Designs B Analyze requirements Create design Analyze and review Utilize prototype to investigate and resolve...
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Service-Oriented Architecture: What Is It and How Can It Help Your Business?

Service-Oriented Architecture: What Is It and How Can It Help Your Business?

Kỹ thuật lập trình

... for different purposes And a service-oriented architecture gives your business the ability to leverage existing services easily while also leaving the option to write new services to fulfill specific ... different manner Service-oriented architectures are essentially about giving existing services new functionality How Service-Oriented Architectures Can Benefit a Business When used by businesses, ... to send the registrant an email with specific directions to the facility without requiring the person to go to a third-party website for that information Instead, a program could be written to...
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Tài liệu Service-Oriented Architecture: What Is It and How Can It Help Your Business? pdf

Tài liệu Service-Oriented Architecture: What Is It and How Can It Help Your Business? pdf

Quản trị mạng

... for different purposes And a service-oriented architecture gives your business the ability to leverage existing services easily while also leaving the option to write new services to fulfill specific ... different manner Service-oriented architectures are essentially about giving existing services new functionality How Service-Oriented Architectures Can Benefit a Business When used by businesses, ... to send the registrant an email with specific directions to the facility without requiring the person to go to a third-party website for that information Instead, a program could be written to...
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Nano means one billionth  major aspects of nanotechnology  what is it  how did it come about  what are the social implications

Nano means one billionth major aspects of nanotechnology what is it how did it come about what are the social implications

Hóa học

... Positive Effects on Society Above: Nanomachines could allow for cleaner energy production Right: Nanomachines in the blood stream patrolling for viruses Positive Effects on Society (Medical Applications) ... manufacturing at top left (F) shows two atoms in the protein, (G) reveals the nucleus of the atom as a tiny speck Below: 35 xenon atoms spell out a familiar logo A demonstration on the molecular level ... Nanotechnology - Deals with moleculues between one and one hundred nanometers in diameter Manipulating individual atoms and manufacturing from the bottom up Major Aspects of Nanotechnology •What...
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Báo cáo y học:

Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx

Báo cáo khoa học

... obesity in humans Arch Intern Med 2008, 168:1609-1616 Colicchio P, Tarantino G, del Genio F, Sorrentino P, Saldalamacchia G, Finelli C, Conca P, Contaldo F, Pasanisi F: Non-alcoholic fatty liver ... with the MS cluster, contributing in the MS risk assessment [8] Although the relationship between inflammatory biomarkers and obesity/MS is not fully clear, central obesity with high visceral fat ... phenotype without IR and young obese individuals with IR, jj) the correlation between the http://www.journal-inflammation.com/content/6/1/6 entity of VAT and SAAT deposition and the severity of...
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Báo cáo y học:

Báo cáo y học: "Remission in psoriatic arthritis: is it possible and how can it be predicted" pdf

Báo cáo khoa học

... Drug-induced remission may be defined as minimal or no clinically detectable disease activity in the presence of continuing drug treatment, which is not stopped or interrupted, but is required to retain ... disease activity Remission has become an attainable goal in the treatment of RA, the recent Combination of Methotrexate and etanercept in Active Early Rheumatoid (COMET) study suggesting high remission ... activity with respect to response to biologic therapies [19,23] In measuring remission in this prospective cohort study we have applied the DAS28, as a validated measure of disease activity in...
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Báo cáo y học:

Báo cáo y học: "Host immune response in sepsis due to ventilator-associated pneumonia: how is it different" pot

Báo cáo khoa học

... Christaki implications of endotoxin tolerance continue to be elusive [4] Although endotoxin tolerance has been implicated in increased susceptibility to secondary infections, a number of studies ... work is needed before those changes are attributed solely to VAP Competing interests The author declares that they have no competing interests References Pelekanou A, Tsagkaris I, Kotsaki A, Karagianni ... decreases mortality in mice challenged with Staphylococcus aureus Shock 2008, 29:512518 10 Murphey ED, Fang G, Varma TK, Sherwood ER: Improved bacterial clearance and decreased mortality can be induced...
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sloan - don't blame the shorts; why short sellers are always blamed for market crashes and how history is repeating itself (2010)

sloan - don't blame the shorts; why short sellers are always blamed for market crashes and how history is repeating itself (2010)

Tài chính doanh nghiệp

... suspicions about fraud or faulty accounting But most shorting is done to offset the risk of holding a convertible bond, of betting on the spread of a merger arbitrage, or of isolating the interest rate ... the stock market continued to fall, this move led to an outright ban on shorting financial shares (As of this writing, short sellers are coming under even more federal scrutiny After reversing ... roiled the markets in 1931, the New York Stock Exchange briefly banned shorting Market-makers had no ability to provide liquidity for transactions, and prices were soon artificially squeezed higher...
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BitLocker: Is It Really Secure?

BitLocker: Is It Really Secure?

Quản trị mạng

... verifies system integrity, BitLocker unlocks the protected volume The operating system then starts and system protection becomes the responsibility of the user and the operating system Figure shows ... long history of vulnerability, such as data theft by inappropriately booting a computer through stolen credentials, using external attack tools such as bootable operating systems on CD-ROM or ... operating system, while Windows Server 2008 can additionally encrypt other volumes By design, BitLocker encrypts the entire Windows operating system volume on the hard-drive, including the operating...
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HOW GOOD IS THE EVIDENCE - INTUITION, PERSONAL EXPERIENCE, TESTIMONIALS, AND APPEALS TO AUTHORITY

HOW GOOD IS THE EVIDENCE - INTUITION, PERSONAL EXPERIENCE, TESTIMONIALS, AND APPEALS TO AUTHORITY

Kỹ năng đọc tiếng Anh

... the authority have on this particular subject? ? Was the authority in a position to have especially good access to pertinent facts? ? Is there good reason to believe that the authority is relatively ... presented For example, if a public university president is asked whether cuts in funding for education are bad for the university, he will in all probability answer "yes" and give a number of good ... authority's personal interest in the topic For example, we want to be especially wary when an authority stands to benefit financially from the actions she advocates Because an authority can have...
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HOW GOOD IS THE EVIDENCE - PERSONAL OBSERVATION, RESEARCH STUDIES, CASE EXAMPLES, AND ANALOGIES

HOW GOOD IS THE EVIDENCE - PERSONAL OBSERVATION, RESEARCH STUDIES, CASE EXAMPLES, AND ANALOGIES

Kỹ năng đọc tiếng Anh

... research findings? Like appeals to any authority, we cannot tell about the dependability of research findings until we ask lots of questions Society has turned to the scientific method as an important ... evidence should be based on the sampling of a variety of different kinds of college students in a variety of different kinds of college settings Students at a small private school in the Midwest ... called the Faulty Analogy fallacy F: Faulty Analogy: Occurs when an analogy is proposed in which there are important relevant dissimilarities In one sense, all analogies are faulty, because they...
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Style - It’s Not What They Say but How They Say It

Style - It’s Not What They Say but How They Say It

Kỹ năng đọc tiếng Anh

... – STYLE: IT’S NOT WHAT THEY SAY BUT HOW THEY SAY IT – Which version uses the same sentence structure throughout? a version A b version B Style: a distinctive way of writing or speaking ... and reader In business, as in most writing, the audience usually determines the writer’s style The writer of letter A is probably capable of writing in the style of letter B, but because she has ... style appropriate to business and only records the facts The other describes the meeting in a style appropriate for general readers interested in the feelings of the people involved 104 – STYLE:...
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The BMATT course - What is it

The BMATT course - What is it

Anh ngữ phổ thông

... evaluate the resources they have, formulate a training plan including formulating their aims and activities and then implementing the training programme they have put together Answer the following ... tactical advantage of the weapon and its capability of firing single rounds or bursts is in producing: a Quick, accurate fire at short-range opportunity targets b A high rate of accurate controlled ... The BAYONET is shaped to provide good thrust penetration It has a cutting edge, blade channels and a ribbed portion for rope cutting A slot at the forward end is for use with the scabbard when used...
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Agile Testing What is it? Can it work?

Agile Testing What is it? Can it work?

Kỹ thuật lập trình

... to poor quality and an excuse for hacking I think that XP is exciting and will improve the practice of testing in the industry    XP developers are writing unit tests and unit testing tools ... Refactoring “User Stories" Acceptance Testing The Role of Testing Testing is the headlights of the project  Where are you now? Where you headed? Testing provides information to the team  This ... more." www.agilemanifesto.org What is Agile Testing? Testing practice that follows the agile manifesto, treating development as the customer of testing  In this light the context-driven manifesto...
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