oxidative carbonyl stress in the regulation of renal function and blood pressure
báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt
... MYB60 proteins and other closely related proteins from subgroup 1: a distinctive PHEEG signature in the MYB domain, located in the loop connecting the R2 and R3 repeats, and the lack of the first ... stage, the onset of ripening and the accumulation of sugars are correlated to increasing levels of ABA in the berry [30], suggesting a possible negative effect of the hormone on the expression of ... primordia in (A), showing staining at the base of trichomes (C) Detail of an emerging later root (D) 15-day-old pVvMYB60:GUS seedling (E) Magnification of leaf primordia in (D), showing staining of...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... of GSK3 (using Li or SB-415286) appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation ... greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) will shift the balance towards...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... death and inflammatory insult Understanding the molecular basis of an inflammatory stress response, in the form of heat stress forms the basis of many disease states including heat stroke and fever ... factor involved in the regulation of inflammation and cytokine production NFkB exists in an inactive form bound to IkBa in the cytoplasm The binding of IkB to NFkB prevents its translocation to the ... pERK, pP38 and pJNK The absence of ANXA1, on the other hand, markedly increased basal expression of these markers, thereby relating cytokine regulation to the activation or inactivation of the MAPK...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1 J Biol Chem 282, 168–175 Sandoval R, Pilkinton M & Colamonici OR (2009) Deletion of the p107 ⁄ p130-binding domain of Mip130 ⁄ LIN-9 ... In G0, proteins appear to bind to the CDE ⁄ CHR, as monitored by in vivo footprinting According to these early experiments all binding is lost in G2 ⁄ M In contrast, constitutive binding to the ... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish It ... Fig Functional role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum Cells were fixed on day of differentiation and stained with hematoxylin and eosin One of ... role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a and ... IDM (10 lgÆmL)1 insulin, lm dexamethasone, and 0.5 mm IDM) Cells were then maintained in DMEM containing 10% fetal bovine serum and lgÆmL)1insulin The medium was replaced every other day Mature...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... to bind to the NR2A C-tail is independent of its kinase activity, and that dysfunction of the SH3 and ⁄ or SH2 domains does not affect this interaction The regulation of NMDARs by Src and other...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocardin, and that the RPEL motif itself is an actin-binding element RPEL1 and RPEL2 of myocardin bind actin weakly ... ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding ... and perinuclear areas of the cell via its N-terminal ABD In the absence of ligand, AR is localized predominantly in the cytoplasm, and its hinge domain and the LBD are tethered to the C-terminal...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... mgÆmL)1) intraperitoneally (60 mgÆkg)1) Two catheters were inserted into the tail veins, one for the administration of pentobarbital and one for the infusion of glucose A third catheter was placed intraperitoneally ... 3, and > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of ... means of glucose administration should the tail vein fail, which was the case in only three animals, the data of which were included After the lines were inserted, pentobarbital was infused continuously...
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... form Initially, determination of the amino-terminal amino acid sequence of purified protein was attempted, but no information was obtained, probably due to the protein modification Therefore, the ... indicates the stop codon Three amino acid residues of the catalytic triad are boxed The single and double lines indicate the putative Ca2+- and GTP-binding sites, respectively That sequence included ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement...
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The Constitution of Private Governance Product Standards in the Regulation of Integrating Markets pptx
... over the content and use of these standards––either by the participation of officials in the elaboration and approval of the standard, or because of the threat of public intervention in case the ... neglect of the phenomenon of the use of standards in modern market regulation seems all the more striking in the light of the preoccupation of modern theorising in sociology, political science and ... Work; DIN 820 and BS 0, the ‘standardisation standards’ of the German and British standards bodies respectively, and the Standardization Guides of Standards Australia and Standards New Zealand The...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... the amount of the interacting proteins but also on the affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in ... Conclusions HIP-1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts ... [29] The ANTH ⁄ ENTH domain of HIP-1 interacts with 3-phosphate containing inositol lipids and stabilizes the growth factor receptor tyrosine kinases by increasing their half-life following ligand...
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AN INCREASING ROLE FOR COMPETITION IN THE REGULATION OF BANKS doc
... to being changed and enforced in the interest of the regulated industry, rather than in the interest of the economy at large General laws, on the other hand, tend to be more immune and therefore ... 1980s In the case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% of the assessable deposits and was the same for all insured institutions regardless of the riskiness of their ... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... before amino acid 71, the region of cleavage would be between amino acids 65 and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the ... 4328 In the present study, we provide new insights into the regulation and function of the molecular complex encompassing CARP and calpain in the N2A region We identified CARP as a new calpain substrate...
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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf
... the binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of ... utilization of galactose when the concentration of galactose is decreasing in the medium To explain the mechanism of MRG19 in facilitating GAL gene induction, under low induction signal, we consider the ... b-galactosidase activity in wild-type and MRG19 disrupted strains bearing the indicated fusion constructs Transformants were grown to D600 of 0.5 and 1.5, in minimal synthetic medium containing glycerol...
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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx
... young and old adults Aging affects the interaction of the somatosensory and visual systems on the ability of the CNS to resolve sensory conflicts and to maintain upright stance equilibrium Therefore, ... the decline in the integrity of many postural regulating systems [14-16], but its effect on the sensory inputs recalibration process remains to be determined One question of interest is whether ... stability depends on the characteristics of the visual environment, and of the support surface, including the size of the base of support, its rigidity or compliance [12,13] Within physiological...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... across the BBB to the sites of axonal injury in the brain [33,37] Both in vitro and in vivo findings suggest that hypoxia/ischemia-induced infiltration of monocytes and macrophages contributes to the ... of inflammatory cytokines and chemokines during hypoxia; whereas NFκB is mainly involved in transcriptional regulation of these genes during the phase of reoxygenation [8,40] The temporal interplay ... molecules (ICAM-1) in the brain and in cultured astrocytes and brain endothelial cells [510] These inflammatory mediators play a critical role not only in the initiation and propagation of ischemica/...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... regulation of cytokines in vivo The results of the co-stimulating experiments did not show any strong evidence of a functional interaction between E2 and IFN on the expression of IFI genes Inconsistent ... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... and IRF7 showed almost no response to TNF in vitro These data suggest that other soluble factors might be involved in the regulation on the gene expression Indeed, high levels of interferon in...
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Báo cáo khoa học: "Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma" ppt
... the indications and the best HAs to choose Looking to the future, minimally invasive surgery will further drive the use of topical HA in the urologic field They offer promising employ in the ... bleeding, for tumors of cm or less of diameter We propose to make use of those different way of achieving haemostasis considering the satisfying results, their handling and their efficacy, in the ... bleeding and nephrotoxicity, suggests a possible employ for FloSeal in the treatment of devastating renal injuries [14,15] Furthermore, a porcine model investigating on the use of FloSeal and...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25