organotropism of lung cancer metastasis and its molecular targeted therapy
Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
... microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the same individuals ... tree to be at increased risk of developing lung cancer, leading to the concept of field cancerization Field cancerization was first proposed in the fifties [64] and its molecular correlates later ... derive a sequential pattern of development for genetic abnormalities in preneoplastic lung epithelium Role of viruses in lung tumorigenesis The understanding of lung cancer molecular approaches has...
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MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS
... ABSTRACT Liyun Cao MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance Our laboratory ... upregulation and EMT in vitro and tumor dissemination in vivo, which confirms the link between TGF-β1 and TG2 in EMT and tumor metastasis TG2 expression was correlated with the number and size of self-renewing ... epithelial OC is the major form of OC, OC is used later on OC is the ninth most common cancer in women (not counting skin cancer) and the fifth cause of cancer death of women in United States About...
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Lung cancer - The diagnosis and treatment of lung cancer pdf
... 2002 Lung cancer is the most common cause of cancer death for men, who account for 60% of lung cancer cases In women, lung cancer is the second most common cause of cancer death after breast cancer ... for lung cancer are very poor In England, for patients diagnosed between 1993 and 1995 and followed up to 2000, 21.4% of men and 21.8% of women with lung cancer were alive year after diagnosis and ... suspicion of lung cancer, patients should be offered urgent referral to a member of the lung cancer MDT, usually the chest physician D 1.1.7 Patients should be offered an urgent referral to a member of...
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Mouse models of breast cancer metastasis: Anna Fantozzi and Gerhard Christofori pdf
... 14 Lung Wap-HGF Mammary gland 89 1–2 22 Lung H19-IGF2 Mammary gland 50–100 >9 38 Lung, spleen; liver [16,110] 10–18a 50 Lung, liver [111] 100 9.8a 39 Lung [112] 100 3.5a 66 Lung 86.8 8a 12 Lung ... lymphangiogenesis and in the formation of lymph node metastasis [15] The role of lymphangiogenesis and angiogenesis in breast cancer metastasis is a major focus of current research Mammary overexpression of ... receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 2005, 5:341-354 Cavallaro U, Christofori G: Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nat Rev Cancer...
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The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust pptx
... where lung cancer rates are high because of unvented indoor burning of coal for heating and cooking in homes (22) The effect of tobacco on lung cancer risk in that study was weak in the presence of ... study of U.S railroad workers and lung cancer Cancer Causes Control 2006;17(7):911–919 Emmelin A, Nystrom L, Wall S Diesel exhaust exposure and smoking: a case-referent study of lung cancer ... Division of Cancer 14 Article | JNCI Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA (JHL, RGZ, SW); Formerly of Division of Cancer Epidemiology and Genetics, National Cancer...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we specifically focus on the role of Htt-interacting protein HIP-1 and its molecular ... transcription caspase-6, and caspase-3 Cleavage of Bid and release of cytochrome c and apoptosis-inducing factors from the mitochondria are also observed Coexpression of wild-type htt exon and Hippi decreases ... proapoptotic activity of HIPPI or HIP-1 may thus be dependent on the presence or absence of its interacting partner HIP-1 and HIPPI respectively HIPPI and its interacting partners – regulation of apoptosis...
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Báo cáo y học: "Lung cancer metastasis to the scapula and spine: a case report" pot
... 25% of people with lung cancer not have symptoms from advanced cancer when their lung cancer is found [10] Maghfoor reported that 7–10% of patients with lung cancer are asymptomatic and their cancers ... of its lack of superimposition and its high contrast resolution [22-24] 10 11 12 13 14 Conclusion Lung cancer is a significant and aggressive primary cancer with a predilection for skeletal metastasis ... American Cancer Society: Cancer Facts and Figures Atlanta 2007 U.S Cancer Statistics Working Group: United States Cancer Statistics: 2004 Incidence and Mortality Atlanta (GA): Department of Health and...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... 1-1: Survival of primary and metastatic CRC Figure reproduced with modifications from Cancer statistics 20132 Preventing CRC metastasis requires a precise molecular understanding of the metastatic ... a range of cancerous and disease conditions as shown in Table 1-1 Table 1-1: STMN1 up-regulation in cancer and disease Representative publications between 1988 and 2013 First report of STMN1 ... accessibility of barium sulfate to early lesions and three-dimensional reconstruction of the inner colon surface Since these often still require verification by standard colonoscopy, the utility of virtual...
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Study of the morphological and functional alterations of high endothelial venules in the regional lymph nodes to tongue cancer patients and its clinico pathological correlations
... prognosis of squamous cell carcinoma of the tongue and it guides therapeutic decisions The Paget‟s “Seed and Soil” theory for cancer and its metastasis is well known and established Angiogenesis and ... how B is a subset of A and C is a subset of B.) xxv Introduction and Background Cancer remains one of the leading causes of morbidity and mortality worldwide Oral and pharyngeal cancers is ranked ... evaluation of the patient with head and neck cancer PET scans are used most often to reveal cancer and to examine the effects of cancer therapy by characterizing biochemical changes in the cancer...
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The effect of vitamine E and bta carotence on the incidence of lung cancer and other cancers in male smokers
... The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses ... permission Copyright © 1994 Massachusetts Medical Society All rights reserved The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses ... permission Copyright © 1994 Massachusetts Medical Society All rights reserved The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses...
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ESTROGENIC ACTIVITY LEVEL OF NAKDONG RIVER BASIN AND ITS CONTROL BY WATER TREATMENT PROCESSES
... treatment plants, and sewage treatment plants one each from the upstream of Andong area to downstream of Busan area of Nakdong river basin Estrogenic activity and concentration of estrogenic substances ... Andong Daegu Busan Andong Waegwan Gangjung Daegu Gumho Riv Goryung Brd Hwang Riv Jeokpo Brd Namji RESULTS AND DISCUSSION Nam Riv Fig shows the sampling points along of Nakdong River in May, and ... October 2002 and in March, and September 2003 Samples were collected from points in Mylyang Riv Samrangjin Busan Fig Sampling points of Nakdong River basin - 204 - Journal of Water and Environment...
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A study of semantic and pragmatic features of the adjective warm and its vietnamese equivalents
... science of government or governing, especially the governing of a political entity, such as a nation, and the administration and control of its internal and external affairs 3.1 RESEARCH DESIGN AND ... review of the research Chapter 3: “Methodology and Procedures” mentions the method and procedures of the research Chapter 4: “Findings and Discussions” is the main frame of need to understand semantics ... hyponym of animal 2.2.1.7 Semantic field The semantic structure of vocabulary of a language can be studied in a precise and systematic way by means of componential analysis of which the theory of...
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Tài liệu Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR pptx
... aggressiveness and metastasis [23], and S100P may be a diagnostic marker of nonsmall-cell lung cancer [30,31] PLAU has also been examined in relation to lung cancer prognosis [32] The set of 12 well-characterized ... family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer Cancer Res 2004, 64:5564-5569 32 Offersen BV, Pfeiffer P, Andreasen P, ... diagnosis, better prognosis, and more effective drug targeting Page of 12 Although numerous papers examining lung cancer tissues and/ or lung cancer cell lines using DNA microarrays and/ or qPCR have been...
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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
... behaviour and a low unstable inhibitory activity, and for I137A a biphasic loss of activity (Fig and Table 3) The phenotype of these substitutions is therefore different from that of N139A, T146A and ... assay and expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of latency transition expressed as the functional half-life, t½ The averages and standard ... assay and expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of latency transition expressed as the functional half-life, t½ The averages and standard...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... role in the etiology and progression of numerous epithelial malignancies, including lung cancer [4] Moreover, the function of EGFR mutations in survival of lung cancer patients and clinical respones ... breast cancer cells, we will determine whether miR-125a-5p regulates the phosphorylation of Akt and ⁄ or ERK1 ⁄ in lung cancer cells, and whether miR-125a-5p downregulates ErbB2 and ErbB3 in lung cancer ... regulate lung cancer cell migration and invasion in vitro, and that this was frequently decreased in lung cancer patients Our data strongly implicate miR-125a-5p as a potential inhibitor of tumor metastasis...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
... are examined by Liu and Pan (2003), Liu, Longstaff, and Pan (2003) and Das and Uppal (2001) Dufresne and Hugonnier (2001) study the impact of event risk on pricing and hedging of contingent claims ... include Gilboa and Schmeidler (1989), Epstein and Wang (1994), Anderson, Hansen, and Sargent (2000), Chen and Epstein (2002), Hansen and Sargent (2001), Epstein and Miao (2003), Routledge and Zin (2002), ... types of random shocks One is a standard diffusive component, and the other is pure jump, capturing rare events with low frequency and sudden occurrence While the probability laws of both types of...
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Factors infl uencing the risk of breast cancer – established and emerging ppt
... breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control, 8, pp49-56 18 Collaborative Group on Hormonal Factors in Breast Cancer ... of women who abstain from alcohol develop breast cancer by the time they are 80 years old, but of those drinking between units and units/day 10.1% and 11.6% respectively will develop breast cancer ... (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer Lancet,...
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Báo cáo "On the asymptotic behavior of delay differential equations and its relationship with C0 - semigoup " potx
... Eq.(13) (see [7, 11, 12]) Applying the process of argument of parts 2.1 and 2.2 to the uniformlly stable and asymptotic equivalence of above model of population, we will give the following results ... Asymptotic equivalence of systems of differential equations, Results of mathematic science 40 (1985) 245 (Russian) [4] M Svec, Itegral and asymptotic equivelence of two systems of diffrential equations, ... solution x(t) ≡ of Eq.(4) is uniformly stable (2) If limt→∞ T (t) = 0, then the null solution x(t) ≡ of Eq.(4) is uniformly exponential stable Proof Throughout this paper in proof of theorems, we...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... yeasts, mammalian cells and plants as a component of the docking complex and a point of convergence of the PEX5- and PEX7-dependent import pathways [15–17] The N-terminal part of PEX14 interacts with ... (first lane), band to TbPEX14-N,H (last lane), band to the complex formed by the two proteins (lane 3), and bands and correspond to noncomplexed TbPEX5 and TbPEX14-N,H, respectively (lane and 5) association ... after centrifugation of the treated cell suspensions and the preparation of a Western blot of the resulting supernatants The subcellular distribution of PYK, ALD, GAPDH and TIM is shown for procyclic-form...
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A BRIEF REVIEW OF CREATIVE ACCOUNTING LITERATURE AND ITS CONSEQUENCES IN PRACTICE pptx
... Outside the limits of laws and standards Within the limits of laws and standards Return: Earnings per share (EPS) Fraud Main research streams Name of the research stream Main objective Type of research ... manipulated profits A factor of the weak conformity with the accounting standards seems to be the low quality of the audit trials Falkman and Tagesson (2008) describe and explain the impact of the legislation ... first of all, the presentation of a frame for the understanding of the creative accounting practices, to the identification of the protagonists, of the conditions favouring these practices and...
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- the parts of a friendly letter and its meaning
- the development of lung cancer
- denial of service dos attack and its possible solutions in vanet
- small cell lung cancer metastasis
- design of a training program and its execution ppt
- serum creactive protein and risk of lung cancer a casecontrol study
- dietary intake and the development of lung cancer
- logistic regression treatment of lung cancer and diagnosis of heart attacks
- consumption 1990 and incidence of lung cancer 2008
- the presence of ra and its molecular transducers in the developing cns
- differences in the process of lung cancer development between smokers and never smokers
- time dose and fractionationin the treatment of lung cancer
- and metastasis by a combination of anti vegf c and enhanced il 12 therapy in an immunocompetent mouse mammary cancer model
- neutron capture therapy of cancer nanoparticles and high molecular weight boron delivery agents
- male 59yo brain metastasis of lung cancer
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