the presence of ra and its molecular transducers in the developing cns
Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... (C), in the presence of 100 lM MPP+ (D), in the presence of 200 lM MPP+ (E), in the presence of 100 lM MPTP and 50 lM dopamine (F), in the presence of 200 lM MPTP and 50 lM dopamine (G), in the presence ... solid line), in the presence of 100 lM neurotoxin ( , dotted line), in the presence of 200 lM neurotoxin ( , dotted line) and in the presence of neurotoxin and 50 lM dopamine (h, dashed line) • 1692 ... role and enhances the rate of neurodegeneration in the initial stages In the presence of MPTP, dopamine presumably cannot undergo auto-oxidation The rate of fibrillation of a-synuclein cannot be inhibited...
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Characterisation of the role of bifocal and its interacting partners in drosophila development
... interacting partners and their role in the developing cytoskeleton The work in this thesis focuses on the developing fly eye, the targeting of axons from the eye to the brain and the anchoring of ... roles in regulating the guidance of both crossing and non-crossing axons at the ventral midline of the developing vertebrate spinal cord and the Drosophila ventral nerve cord For example, these ... across the midline to the contralateral side of the CNS Interestingly, these Introduction 19 axons cross the midline only once Other neurons extend axons that never cross the midline; they project...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... HIP-1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts strongly ... Htt-interacting protein HIP-1 and its molecular partner HIPPI in the regulation of apoptosis and transcription, the two processes that are altered in HD [7,8] HIP-1 – its interacting partners and ... the amount of the interacting proteins but also on the affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in...
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Tài liệu The Transformation of Banking and Its Impact on Consumers and Small Businesses docx
... popular as online brokerage Financial integration The final often-cited change in the banking system is the least certain the spread of diversified financial firms offering a wide array of services, ... SUMMARY AND CONCLUSIONS The banking industry is undergoing three major changes the consolidation of the industry, the spread of Internet banking, and the increased freedom to combine banking with other ... Will the transformation of banking now under way hurt consumers by raising the price or reducing the quality of these services? Or will the changes benefit consumers by expanding the array of services...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... of TfR2 are highest in hepatocytes, the predominant site of HFE expression, and recent studies have confirmed that the two proteins are capable of interacting [33,34] The nature of these interactions ... regulate transferrin binding (Fig 7B) By contrast, cells transfected with either the single or double mutants were all capable of reducing transferrin binding In each case, however, there tended ... iron levels by binding of transferrin to the type transferrin receptor [15] The crystal structure of HFE complexed to the TfR1 has been determined and although the two proteins interact over a relatively...
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the welding of aluminium and its alloys
... between the grains there is a mismatch, a loss of order, in the orientation of these arrays Both the grain boundaries and the size of the grains can have a marked effect on the properties of the ... Increasing the arc current increases the temperature of the weld pool and thereby increases the rate of absorption of hydrogen in the molten metal Conversely, in the flat welding position increasing the ... working one or two of the dimensions of the item being cold worked are reduced with a corresponding increase in the other dimension(s) This produces an elongation of the grains of the metal in the...
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Báo cáo khoa học: Oxygen binding and its allosteric control in hemoglobin of the primitive branchiopod crustacean Triops cancriformis pdf
... is independent of proton and Mg2+ concentration Increasing the Mg2+ concentration (0–100 mm) induced a left shift of the Hill plot in the half-saturation range (Fig 4C,D) without affecting the ... according to: ð1Þ s2 i Y ð4Þ ^ where Yi and Y i are the measured and predicated saturations of the ith point, and k is the number of data points Adair equation To determine the minimum number of interacting ... uncertainty in the remaining parameters In the Adair formalism none of the parameters are shared between the curves, thus, the total set contains 24 free parameters Despite this very large number of...
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Báo cáo sinh học: " Possible active origin of replication in the double stranded extended form of the left terminus of LuIII and its implication on the replication model of the parvovirus" pptx
... transfection of LuIII Lt-Lt/pGlu∆Xba, contributed in the analysis and interpretation of the data, participated in the idea and design of the models proposed and in the drafting and revision of the manuscript ... end hairpin of LuIII in double stranded form The smaller of the two bands, of greater intensity, may represent the left hairpin with an alternate conformation A faint band of similar migration ... gesting that the left hairpin of LuIII does constitute a replication origin in the extended double stranded hairpin configuration Given the functionality of the left hairpin of LuIII as an origin...
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báo cáo hóa học:" Unsaturated phosphatidylcholines lining on the surface of cartilage and its possible physiological roles" potx
... experiment, the collection, analysis and interpretation of data, the drafting the manuscript and acquisition of funding RWC contributes to the analysis and interpretation of data, drafting the manuscript ... pressure of the compartments needed to stop further water transmission across the membrane At the beginning of each experiment, the fluid heights indicating the pressure in both compartments, i.e either ... manuscript and acquisition of funding AO contributes to the analysis and interpretation of data, drafting the manuscript and acquisition of funding All authors have read and approved the final manuscript...
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báo cáo hóa học:" Possible active origin of replication in the double stranded extended form of the left terminus of LuIII and its implication on the replication model of the parvovirus" ppt
... transfection of LuIII Lt-Lt/pGlu∆Xba, contributed in the analysis and interpretation of the data, participated in the idea and design of the models proposed and in the drafting and revision of the manuscript ... end hairpin of LuIII in double stranded form The smaller of the two bands, of greater intensity, may represent the left hairpin with an alternate conformation A faint band of similar migration ... gesting that the left hairpin of LuIII does constitute a replication origin in the extended double stranded hairpin configuration Given the functionality of the left hairpin of LuIII as an origin...
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báo cáo hóa học:" Research Article Entire Solutions for a Quasilinear Problem in the Presence of Sublinear and Super-Linear Terms" potx
... The class of problems 1.1 appears in many nonlinear phenomena, for instance, in the theory of quasiregular and quasiconformal mappings 1–3 , in the generalized reaction-diffusion theory , in the ... result of Yang and Xu and to complement other works see, e.g., 8–20 and references therein for more general nonlinearities in the terms f and g which include the cases considered by them The principal ... the turbulent flow of a gas in porous medium and in the non-Newtonian fluid theory In the non-Newtonian fluid theory, the quantity p is the characteristic of the medium If p < 2, the fluids are called...
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Báo cáo y học: " Profile of subjective quality of life and its correlates in a nation-wide sample of high school students in an Arab setting using the WHOQOL-Bref" pot
... generally satisfied with their circumstances of living, - and their average QOL domain scores would be high, in comparison with the international data - In view of the robust findings in the ... items The second and third ways consist of transforming the raw scores In the second way, the raw scores are transformed into scores that range from 4-20, to be in line with the WHOQL -100 Instrument ... twice in a four week period Operational definitions We accepted the WHO definition of QOL as individuals’ perception of life in the context of the culture and value system in which they live and in...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... among the high and the poor knowledge-performers in the three groups for age, durations of illness, the duration of the current episode, and the number of visits with a psychiatrist over the last ... discrimination between the high and the low performing groups Modifying the distracters to increase the difficulty level of these items can make these items more discriminating Alternatively, changing ... becoming clinically depressed? b Being involved in talk therapy (psychotherapy) a One in 1000 c Staying sober b One in 50 d Stopping antidepressant medications if feeling well c One in d One in...
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Báo cáo khoa học: "The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival" ppt
... death In the present study, we investigated the release of VEGF, and the expression and distribution of VEGF and its receptors in the lung during the early onset of ALI induced by intestinal ischemia-reperfusion ... endothelial cells (Figure 4a) In the IIR group, the staining was redistributed in the cytoplasm, with a granular-like appearance in the infiltrated mononuclear cells in the interstitium An increased ... significantly increased in the IIR group (Figure 1b) VEGF increased in the BAL but decreased in the lung tissues after IIR We then investigated the alterations of VEGF and its receptors in IIR-induced...
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Báo cáo y học: "The allosteric modulation of lipases and its possible biological relevance" docx
... binding of diol at the allosteric binding site does neither result in blocking of the active site nor in complete inhibition of the enzyme as described in literature generally [15] In fact the ... bound to albumin [15] The temporarily increased concentration of FFAs in the blood increases the risk of interactions with the endothelial cells of the blood vessels This mainly concerns the arteries ... aãe n(5)i = Using these settings the simulation results in the same linear development of the amounts of diol and monoacetate as observed in the experiment at the beginning of the reaction (Fig...
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An investigation on the root system of mangroves and its influence on current flow
... estimated 13.0% in the 1820’s to only 0.5% of the total land area and it is now found only in small patches in the northern part of the Singapore main island and on Pulau Tekong and Pulau Ubin (Hsiang, ... investiagtion in determining the roughness coefficients of floodplains vegetated with hedges and orchards They found that the Chezy coefficient of the floodplain is mainly influenced by the average spacing ... from the main trunk or lower branches of the Rhizophora genus It is believed that the number of prop roots and the complexity of their structure are response to the intensity of wind and wave stresses...
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Ab initio and DFT investigation of the mechanism and hydration pattern of sialidase and its inhibitor
... 6.6 Binding affinity of 4-guandino-DANA 136 6.7 Investigation of binding affinity of tamiflu 138 6.8 Analysis of binding affinity of BCX as a function of water molecules 140 6.8.1 Binding affinity ... function of the water molecules and therefore invalidates the specific binding of explicit water molecules in the functional site of the respective substrates The presence of polarized C–O link in the ... of C7 substituents on the binding affinity of N-DANA 161 7.5.2 Binding affinity of C7 substituent of N-DANA in solvent phase 164 7.6 Effect of C7 substituents on the binding affinity of 4-guandino-DANA...
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Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
... doi:10.1038/cddis.2011.12 The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling, Hui-Min Lin, Kuan-Boone Tan and Gigi N.C Chiu International ... presenting author) Podium Presentation The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling*, Hui-Min Lin, Kuan-Boone Tan and ... main molecular signaling pathways that lead to apoptotic cell death: the intrinsic pathway and the extrinsic pathway (Figure 1.2) The intrinsic pathway is usually initiated in the presence of intracellular...
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A study of the immunomodulatory characteristics of FIP fve protein and its adjuvant effects in tumor immunotherapy
... Delineation of the proposed carbohydrate binding site of the Fve protein 194 5.2.2 Identification of cellular receptor (s) involved in Fve interaction 195 5.2.3 Functional characterization of the ... in above mentioned clinical trial The rationale for including PGE2 in the maturation protocol is to endow the ex vivo-generated DCs with the capacity to migrate159, but PGE2, in the context of ... period of three to seven months5,6 Due to the limited understanding of immunologic defects in the nude mice at that time, these results were highly convincing and thus resulted in the abandonment of...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... et al., 2001) The contradicting roles of p300 in the stabilization of p53 and MDM2 proteins and in promoting the degradation of p53 by MDM2 may be necessary for the maintenance of the MDM2/p53 ... 2005) Interestingly, the N-terminal domain of DNMT1 plays a role in the stabilization of the protein This has been shown by the deletion of the first 118 aa to force initiation of translation at the ... Doxorubicin and 2.5μM 5AzadC for 24 hr in MCF7 and MCF-10A cell lines 133 LIST OF DIAGRAMS Schematic diagram of the 1616 amino acid human DNA Methyltransferase (DNMT1) protein showing the binding...
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