... A589G_G590C T100G_C102A T100G_C102A T205G_C206A 18 8 -19 0 18 8 -19 0 18 8 -19 1 18 8 -19 1 RKT RKT RKTT RKTT PKA PKC PKC PKA A568G_C569A_A570C A568G_C569A_A570C A571G_C572A A571G_C572A 18 9 -19 2 KTTS [R/K]X[pS/pT] ... residues 65-69, and 18 9 -19 2 and 2 01- 205 It should be noted that the aa189 -19 2 site overlaps with a PKC/PKA phosphorylation site (aa188 -19 1) To assess whether PKC or PKA was responsible for the phosphorylation ... Meltzer P., Morin P.J., and Weeraratna A.T Claudin -1 overexpression in melanoma is http://www.medsci.org Int J Med Sci 2009, 6 10 11 12 13 14 15 16 17 18 regulated by PKC and contributes to melanoma...
... Genes Dev 19 99, 13 :15 01- 1 512 Page 11 of 12 (page number not for citation purposes) Arthritis Research & Therapy Vol 10 No Nakai et al 28 Hunter T, Pines J: Cyclins and cancer II: cyclin D and CDK ... rat c-myc, p15, p 21, p27 and -actin were designed based on the coding sequences from GenBank ([Genbank:BC0 916 99, AF474979, BC100620, NM_0 317 62, NM_0 311 44] respectively), and synthesized by Invitrogen ... & Therapy Vol 10 No Nakai et al many); mM Na3VO4 and mM NaF) Cell lysates were sonicated for 10 s to shear the DNA, then centrifuged at 10 ,000 g for 10 at 4°C The supernatant was collected and...
... conducted from southern universities and museums, notably the University of Queensland (UQ), the University of Sydney, the Australian Museum, andthe Queensland Museum, often through the Island Research ... 19 60s and early 19 70s Thethen Premier of Queensland and other politicians entered into newspaper debate with prominent scientists on the extent of damage by the crown-ofthorns starfish to the ... Parliament of the Queensland Government have the potential to completely remove such practices One is the Coastal Planning and Management Act (19 95), andthe other is the Integrated Planning Act (19 97)...
... of Figures viii Abbreviations xi Chapter – Introduction 1.1 Voltage-gated calcium channels 1.1 .1 The1 subunit 1. 1.2 The β and α2δ subunits 1 1.2 CaV1.3 channels 1. 2 .1 Unique biophysical and ... through CaV1.3A 212 3V, CaV1.342a and splice variants Δ 41, 43i, Δ44 and 48a- Figure 4 .11 Recovery from inactivation in CaV1.3A 212 3V, CaV1.342a and splice variants Δ 41, 43i, Δ44 and 48a- Figure 4 .12 Density ... Alignment of the C-terminal sequences of the L-type CaV1.3 with CaV1.2 and CaV1.4 shows high conservation in the EF-hand and IQ motif (Figure 1. 1) Alternative splicing of the CaV1.3 in the C-terminus...
... 吕思勉《中国制度史》(上海:上海古籍出版社,2006)。 范文澜《中国通史》(北京:人民出版社 19 86)。 马克思·韦伯《儒教与道教》(南京:江苏人民出版社 19 93)。 傅斯年〈战国子家叙论〉,见《中国古代思想与学术十论》(桂林:广西示范大学出 版社,2006),页 85 -13 4。 10 刘笑敢《庄子哲学及其演变》(北京:中国社会科学出版社, 19 87)。 11 司 马 迁 〈 报 任 安 书 〉 , 见 严 可 ... utilit ari anism inherited and absorbed the el ement s V of rites and musi c from the Zhou politi cal culture Xun Zi ’s empiricism reflect ed the t rend of ret urning to the empi ri cal vi ews espoused ... 试论荀子的经验性格及其成因 93 结论 第五章 10 2 结论 12 9 III 参考书目 13 3 IV ABSTRACT Xun Zi was one of t he great est C onfuci an thinkers in the pre-Qin peri od The purpose of thi s t hesis is to i nterpret the basi c charact...
... goes quickly over to thedoorand draws the curtain aside, to see that it is shut, then comes back to LARRY, who is huddling over the fire.] Come, Larry! Pull yourself together and drop exaggeration! ... radius of the light.] [Staring] Are you ill? [LARRY stands still again and heaves a deep sigh.] KEITH [Rising, with his back to the fire, and staring at his brother] What is it, man? [Then with ... TheFirstand Last PERSONS OF THE PLAY KEITH DARRANT, K.C LARRY DARRANT, His Brother WANDA SCENE I KEITH'S Study SCENE II WANDA's Room SCENE III The Same SCENE I It is...
... andthe stored-program computer A Memory for EDSAC EDSAC, ACE and LEO Not just EDSAC First steps in programming Wilkes, Wheeler and Gill The last days of the EDSAC 1 8 11 11 13 14 17 19 21 21 ... determine which of the other two is the man and which is the woman He knows them by labels X and Y, and at the end of the game 16 he says either ‘X is A and Y is B’ or ‘X is B and Y is A’ The interrogator ... (March 19 51) , WHIRLWIND (March 19 51) , IAS (summer 19 51) and EDVAC (late 19 51) In Germany Konrad Zuse designed a series of ingenious electromechanical computers between 19 38 and 19 45, but these...
... the lower left to the lower right, andthen heads for the upper right The Broken Road” circles in the upper left before heading to the upper right And moves directly from the upper left to the ... identified, these uncertainties were narrowed down Two seemed simultaneously most uncertain and most critical to the issue at hand These chosen two were then overlaid on axes, where the endpoints ... several, as China and India wield greater influence in both the United Nations andthe World Trade Organization, andthe EU continues a steady expansion and integration The problems of the Middle East...
... The core of protein B [23] has 12 exposed potential nucleophiles (serines 34, 44, 92, 10 9, 11 0, 12 6; threonines 36, 49, 57, 68, 11 1, 11 7, 12 3, 12 5; cysteine 88), all of which are exposed to the ... investigate the roles of the residues near to the cleavage site in the rate and position of cleavage because it seemed likely that theside chains near to the cleavage site were important in the autocatalytic ... N-terminal to residue 13 To investigate the role of the residue immediately N-terminal to the cleavage site and to see whether the G13Q mutant could be further stabilized by removal of sidechain functionality...
... Sometimes he draws them on paper He then associated dates with the pictures, using imagery to better understand the order of events Damon is good at seeing the big picture, finding themes, and drawing ... is the one you count on to organize the party, send out the invitations, get the food, and find people to help decorate The rightbrain thinker excels at creative games like charades, andthe ... logic and sense • retain information using words, numbers, and symbols • see only parts of the whole idea, which guide them in their logical, step-by-step gathering of information • express themselves...