fibroblast growth factor 23

... Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; NR, not reached; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; ... VEGFR-3 Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor (B) FGF2 uPa ... extracellular matrix; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; MMP, matrixmetallo...

Ngày tải lên: 18/06/2014, 19:20

... Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; NR, not reached; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; ... VEGFR-3 Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor (B) FGF2 uPa ... extracellular matrix; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; MMP, matrixmetallo...

Ngày tải lên: 20/06/2014, 04:20

... that this new delivery system can help tissue regeneration and wound healing by releasing the growth factors in a controlled and temporal manner Base a longer release period, around weeks [13] ... internalization of MSNs, indicating that the MSNs are not only a biocompatible delivery system for growth factors/ proteins, but also an ideal biomaterial for the application in bio-imaging Conclusions ... Bioactive Materials 25:996–997 13 S.H Choi, T.G Park, Int J Pharm 311, 223 228 (2006) 14 R.H Muller, C Jacobs, Int J Pharm 237 , 151–161 (2002) 15 D.D Hile, M.L Amirpour, A Akgerman, M.V Pishko,...

Ngày tải lên: 22/06/2014, 00:20

... normoxia; (c) hypoxia) and presence ((b) normoxia; (d) hypoxia) of fibroblast growth factor (FGF2) Scale bar, 100 µm FGF2, fibroblast growth factor specific type II collagen gene promoter activity [35] ... tension (n = 3) *p < 0.05; **p < 0.001 (Student's unpaired t test) in cell aggregates from fibroblast growth factor (FGF2)-expanded versus non-FGF2-expanded cells P2, passage 2; P3, passage AGCTTCTGTGGAACCATGGAA-3' ... under hypoxia after 14 days in culture AGG, aggrecan; BGN, biglycan; DCN, decorin; FGF2, fibroblast growth factor 2; FMOD, fibromodulin; P2, passage 2; P3, passage Page of (page number not for citation...

Ngày tải lên: 09/08/2014, 07:20

... proinflammatory cytokines and growth factors such as IL-1 [5,11,12] – and potentially fibroblast growth factor (FGF2) (otherwise known as basic fibroblast growth factor) [13] – both of which have ... Arthritis Rheum 1982, 25:1228- 1238 Posever J, Phillips FM, Pottenger LA: Effects of basic fibroblast growth factor, transforming growth factor- beta 1, insulin-like growth factor- 1, and insulin on human ... disc tissue An immunohistochemical analysis of transforming growth factor beta, fibroblast growth factor and platelet-derived growth factor Eur Spine J 2006, 15:588-596 Melrose J, Smith S, Little...

Ngày tải lên: 09/08/2014, 10:23

... present in the IPFP tissue of fibroblast growth factor- 2 (FGF-2) expansion Chondrogenic cultures of infrapatellar fat pad (IPFP) cells and effects of fibroblast growth factor- 2 (FGF-2) expansion ... ascorbate 2-phosphate, 100 nM dexamethasone, 10 ng/mL transforming growth factor (TGF)-β3, and 100 ng/mL insulinlike growth factor- 1 (all from Sigma-Aldrich) Gene expression analysis Quantitative ... of differentiation potential Fibroblast growth factor- 2 (FGF-2) is a potent mitogen for a variety of cell types derived from the mesoderm, including chondrocytes [23, 24] It has been shown to enhance...

Ngày tải lên: 09/08/2014, 10:23

... signaling is transduced through the formation of a complex of a growth factor, a proteoglycan, and a high-affinity fibroblast growth factor receptor (FGFR), which is a transmembrane tyrosine kinase ... Arthritis Research & Therapy Vol 10 No Uchii et al Fibroblast growth factor (FGF) is a family of at least 24 growthregulatory proteins – sharing 35% to 50% amino acid sequence ... osteoarthritis Ann Rheum Dis 2005, 64:694-698 Szebenyi G, Fallon JF: Fibroblast growth factors as multifunctional signaling factors Int Rev Cytol 1999, 185:45-106 Draper BW, Stock DW, Kimmel CB:...

Ngày tải lên: 09/08/2014, 10:23

... endothelial growth factor (VEGF) and basic growth factor (bFGF) In angiogenesis, a number of growth factors (for example Angiopoietin-1, Platelet derived growth factor, Hypoxia inducing factor- 1a, ... basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients Br J Cancer 1997, 76 :238 -43 27 Kondo S, Asano M, Suzuki H: Significance of vascular endothelial growth ... endothelial growth factor J Biol Chem 1994, 269:26988-95 20 Dietz A, Rudat V, Vanselow B, Conradt C, Möhler T: [Predictive value of serum levels of basic fibroblast growth factor, vascular endothelial growth...

Ngày tải lên: 11/08/2014, 20:20

... Fibroblast growth factor receptor is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular ... chondrocytes Matrix Biol 2001, 20 :233 -242 15 Sah RL, Trippel SB, Grodzinsky AJ: Differential effects of serum, insulin-like growth factor- I, and fibroblast growth factor- 2 on the maintenance of ... 44:585-594 Loeser RF, Chubinskaya S, Pacione C, Im HJ: Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor and osteogenic protein in adult human articular chondrocytes...

Ngày tải lên: 12/08/2014, 17:22

... effects of fibroblast growth factor- 4 in endothelial cells Oncogene 2001, 20(21):2655-2663 Aviezer D, Safran M, Yayon A: Heparin differentially regulates the interaction of fibroblast growth factor- 4 ... capabilities of fibroblasts using recombinant growth factors Proliferation of diabetic and wild-type fibroblasts was measured using BrdU incorporation assay (Figure 7a) Diabetic fibroblasts cultured ... tyrosine kinase-1 receptor (VEGF receptor 1); FGF4: fibroblast growth factor 4; MMP-9: matrix metalloproteinase-9; VEGF-A: vascular endothelial growth factor- A Acknowledgements Grzegorz Dyduch, PhD,...

Ngày tải lên: 14/08/2014, 19:22

... Bovin Serum fgf Fibroblast Growth Factor Gene FGF Fibroblast Growth Factor FGFR Fibroblast Growth Factor Receptor HRP Horseradish peroxidase iFGF Intracellular Fibroblast Growth Factor IPTG Isopropyl-β-D-thio-galactoside ... -1- LỜI MỞ ĐẦU Nhân tố tăng trƣởng nguyên bào sợi FGF-2 (Fibroblast Growth Factor- 2) protein đa chức năng, tham gia điều hòa hoạt động nhiều trình thể nhƣ cân nội ... khác FHF1-FHF4 (FGF homologous factors 1-4), chúng không bám vào FGFR nhƣng tham gia vào trình hoạt hóa nội bào, nên đƣợc gọi iFGF (intracellular FGF) - FGF16 đến FGF23 protein chƣa biết rõ đặc...

Ngày tải lên: 08/10/2014, 18:16

... Fibroblast Growth Factor 31 2.6.1 Types of Fibroblast Growth Factor 32 2.6.2 Fibroblast Growth Factor Receptors 33 2.6.3 Basic Fibroblast Growth Factor (bFGF) ... Factor FGF - Fibroblast Growth Factor FGFR - Fibroblast Growth Factor Receptor HSPG - Heparan Sulfate Proteoglycan IGF - Insulin-like Growth Factor PDGF - Platelet Derived Growth Factor PDL - ... acidic Fibroblast Growth Factor bFGF/FGF-2 - basic Fibroblast Growth Factor BMP - Bone Morphogenetic Protein CEC - Capillary Endothelial Factor ECM - Extracellular Matrix EGF - Epidermal Growth Factor...

Ngày tải lên: 05/10/2015, 22:31

... 10,9 Lƣợng FGF-2 (g/l) (T) 0 ,23 ± 0,03 Hiệu thu nhận FGF-2 (E%) 4,42 ± 0,97 Kết ghi nhận đƣợc bảng 3.3 cho thấy trình lên men chủng BL21(DE3)/pET-FGF thu đƣợc 0 ,23 ± 0,03 g protein FGF-2 dạng ... trao đổi cation Tinh chế lực heparin Độ tinh (%) Hiệu suất riêng bƣớc (%) Hiệu suất thu hồi (%) 230 ,33 6,90 100 100 138,34 78,50 60,06 60,06 106,15 97,10 76,73 46,08 - 75 - Luận văn thạc sĩ sinh...

Ngày tải lên: 26/11/2015, 08:21

... BL21(DE3) mang vector pET-fgf2 có khả biểu rhFGF-2 tế bào chất - Đã tiến hành lên men thu nhận đƣợc 0,23g protein rhFGF-2 từ 1L dịch lên men - Đã tinh chế đƣợc protein rhFGF-2 từ dịch lên men sắc ký...

Ngày tải lên: 26/11/2015, 08:21

... Tổng quan tài liệu 1.1 HỌ NHÂN TỐ TĂNG TRƢỞNG NGUYÊN BÀO SỢI FGF (FIBROBLAST GROWTH FACTOR) 1.1.1 Giới thiệu chung Nhân tố tăng trƣởng nguyên bào sợi FGF đƣợc Armelin tìm ... đầu codon CUG có trọng lƣợng phân tử cao (HMW) lần lƣợt 22; 22,5; 24; 34kDa [23] Hình 1.4 Các dạng FGF-2 tạo thành [23] Sự khác biệt cấu trúc FGF-2 có trọng lƣợng phân tử lớn với FGF-2 có trọng ... FGF3, FGF7, FGF10, FGF22; FGF4, FGF5 FGF6; FGF8, FGF17và FGF18; FGF9, FGF16 FGF20; FGF19, FGF21 FGF23 Những nhân tố FGFs không đƣợc xếp vào họ (FGF11-FGF14) có tƣơng đồng trình tự cao với họ FGF...

Ngày tải lên: 26/11/2015, 08:21

... 5ml, Hitrap Heparin HP 5ml (GE Healthcare) - Hệ thống lên men tự động BioTron-LiFlus GX GX-05- 1230 2 thiết bị phụ trợ nhƣ: máy nén khí, hệ thống nƣớc giải nhiệt… - Hệ thống tinh chế AKTA (GE Healthcare)...

Ngày tải lên: 26/11/2015, 08:21

... 25 PADERA, R F (2000) Cell signaling by fibroblast growth factor 2: investigations into interactions between fibroblast growth factor 2, fibroblast growth factor receptor and heparin-like glycosaminoglycans ... of fibroblast growth factorfibroblast growth factor receptorheparin-like glycosaminoglycan complex The National Academy of Sciences 33 WANG, D I K (2000) The effects of fibroblast growth factor ... AL., (1997) Biological Roles of Fibroblast Growth Factor- 2, Endocrine Reviews, vol 18, no 1, pp 26-45 A LOGAN, A BAIRD, (1996) "Fibroblast growth factors," Growth Factors and Cytokines in Health...

Ngày tải lên: 26/11/2015, 08:50

... SN: Identification of the major fibroblast growth factors released spontaneously in inflammatory arthritis as platelet derived growth factor and tumour necrosis factor- alpha Clin Exp Immunol 1991, ... platelet derived growth factor B chain (PDGFB/c-sis) mrna and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor- 1 J Rheumatol ... signaling and fibrogenesis in cultured fibroblasts [26,27] Hence, the reversal of the growth factor- induced synergy by imatinib indicates involvement of specific growth factor signaling pathways With...

Ngày tải lên: 12/08/2014, 12:20

... as a potent inhibitor of hepatocyte growth factor activator (HGFA), a blood coagulation factor XII-like serine protease that converts pro-hepatocyte growth factor (pro-HGF) to the active form ... Morimoto Y & Kitamura N (1995) Activation of hepatocyte growth factor by two homologous proteases, blood coagulation factor XIIa and hepatocyte growth factor activator Eur J Biochem 229, 257–261 Miyazawa ... human hepatocyte growth factor Biochem Biophys Res Commun 163, 967– 973 Brinkmann V, Foroutan H, Sachs H, Weidner KM & Birchmeier W (1995) Hepatocyte growth factor ⁄ scatter factor induces a...

Ngày tải lên: 15/02/2014, 01:20

... for amphiregulin, EGF and transforming growth factor- a are viable [4] These ligands are synthesized as transmembrane proteins, and soluble ligands (growth factors) are released into the extracellular ... activation of the kinase domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, ... Mitsudomi T & Yatabe Y (2007) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity...

Ngày tải lên: 16/02/2014, 09:20