transforming growth factor β

... signaling during transforming growth factor- beta-induced smooth muscle differentiation. J Biol Chem 281, 1765–1770. 143 Deaton RA, Su C, Valencia TG & Grant SR (2005) Transforming growth factor- beta1-induced ... of transforming growth factor- beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 5, 155–162. 153 Broekelmann TJ, Limper AH, Colby TV & McDonald JA (1991) Transforming growth factor ... & Colicelli J (2008) Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor- directed cell migration. Mol...

Ngày tải lên: 07/03/2014, 01:20

... anti-inflammatory cytokine transforming growth factor- b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article. TGF-b1, a member of the large transforming growth factor- b ... post- transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor- a production by transforming growth factor- b1 Tarnjit K. Khera 1 , Andrew D. Dick 1,2 and Lindsay B. Nicholson 1,2 1 ... fluorescent protein; siRNA, small interfering RNA; TGF-b1, transforming growth factor- b1; TIA-1, T-cell intracellular antigen 1; TNF-a, tumour necrosis factor- a; TTP, tristetraprolin. 2754 FEBS Journal...

Ngày tải lên: 22/03/2014, 21:21

... arylhydrocarbon receptor expression by transforming growth factor- b 1 . Mol. Pharmacol. 59, 716 724. 22. Do ă hr, O. & Abel, J. (1997) Transforming growth factor- beta 1 coregulates mRNA expression ... 491]. Nature 394, 909–913. 28. Roberts, A.B. & Sporn, M.B. (1990) The transforming growth factor- bs. In Peptide Growth Factors and Their Receptors I (Sporn, M.B. & Roberts, A.B., eds), pp. ... (1999) Remarkable versatility of Smad proteins in the nucleus of transforming growth factor- b activated cells. Cytokine Growth Factor Rev. 10, 187– 199. 34. Xu, W., Angelis, K., Danielpour, D.,...

Ngày tải lên: 31/03/2014, 23:20

... platelet type ` transforming growth factor. Science 226, 705–707. 41. Kojima, S. and Rifkin, D. B. (1993) Mechanism of retinoid-induced activation of latent transforming growth factor- ` in bovine ... the cellular receptor for transforming growth factor type `. Biochemistry 25, 3083–3091. 3. Massagué, J. (1987) Identification of receptors for type-` transforming growth factor. Methods Enzymol. ... (1997) Transforming growth factor- ` signal- ing in epithelial cells. Pharmacol. Ther. 75, 21. 16. Jin, G. and Howe, P. H. (1997) Regulation of clusterin gene expression by trans- forming growth factor...

Ngày tải lên: 11/04/2014, 07:14

... 0.026 BMI TGF -β1 TGF -β1 TGF -β1 rho = 0.13 rho = 0.18 rho = 0.09 P = 0.46 P = 0.22 P = 0.56 US score ND TGF -β1 TGF -β1 rho = -0.08 rho = 0.05 P = 0.57 P = 0.72 Fibrosis score TGF -β1 ND TGF -β1 rho = -0.09 ... MND, PC, FP, AR Association between serum TGF -β1 and ferritinFigure 2 Association between serum TGF -β1 and ferritin. TGF -β1 , transforming growth factor- beta1. 100 200 300 400 500 600 700 200 180 160 140 120 100 80 60 40 20 Ferritin ... 3: Correlations between TGF -β1 and other parameters CHC N = 36 FL N = 45 NASH N = 42 CRP ND TGF -β1 TGF -β1 r = 0.37 r = 0.29 P = 0.08 P = 0.055 ALT TGF -β1 TGF -β1 TGF -β1 r = -0.02 r = -0.13 r = -0.34 P...

Ngày tải lên: 18/06/2014, 15:20

... Abstract Background: The over-expression of transforming growth factor β- 1(TGF -β1 ) has been reported to cause hydrocephalus, glia activation, and vascular amyloidβ (Aβ) deposition in mouse brains. Since ... purposes) Background Transforming growth factor- β1 (TGF -β1 ) is a multifunc- tional cytokine implicated in developmental processes, immune host defense, and injury repair [for review, [1]]. TGF -β1 contributes ... overexpressing transforming growth factor- beta 1. Am J Pathol 1995, 147:53-67. 4. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E: Chronic over- production of transforming growth factor- beta1...

Ngày tải lên: 19/06/2014, 22:20

... clinical applications of transforming growth factor- beta (TGF-beta). Growth Factors 1993, 8:1-9. 3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor- beta in human ... sequence analysis of simian transforming growth factor- beta cDNA. DNA 1987, 6:239-244. 5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor- beta. A family of growth regulatory peptides. Ann ... R132 Introduction Transforming growth factor (TGF) -β is a dimeric protein of 25 kDa molecular weight, originally isolated from platelets [1,2]. There are three distinct mammalian isoforms, TGF -β1 , TGF -β2 and...

Ngày tải lên: 09/08/2014, 01:21

... Oklu R, Hesketh R: The latent transforming growth factor β binding protein (LTBP) family. Biochem J 2000, 352:601-610. 32. Shi Y, Massagué J: Mechanisms of TGF- β signaling from cell membrane ... molecular bridge by which TGF -β on the Treg orchestrates suppression of the responder cells [6,8,12]. TGF- β signaling and regulation TGF -β is a potent cytokine and growth factor whose biological ... = rheumatoid arthritis; SLE = systemic lupus erythematosus; TβR = TGF -β receptor; TCR = T-cell receptor; TGF = transforming growth factor; Th = T helper cell; Treg = regulatory T cell(s); TSP...

Ngày tải lên: 09/08/2014, 06:22

... catabolic and anabolic factors that develops with age. IL-1 is a catabolic factor known to induce cartilage damage, and transforming growth factor (TGF)-beta is an anabolic factor that can counteract ... common-Smad, Figure 2 Staining of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling molecules in ... by three members of the transforming growth factor- beta superfamily. J Orthop Res 1997, 15:463-467. 8. Izumi T, Scully SP, Heydemann A, Bolander ME: Transforming growth factor beta 1 stimulates...

Ngày tải lên: 09/08/2014, 07:20

... morphogens and growth factors and catabolic cytokines is at the crux of the problem of osteoarthritis. One such signal is transforming growth factor- β (TGF -β) . The impaired TGF -β signaling has ... in this journal of anabolic growth factor, trans- forming growth factor- β (TGF -β) signaling in articular cartilage in aging mice [2]. This commentary will discuss TGF -β signaling and osteoarthritis ... (Drosophila melanogaster) involved as intracellular substrate for TGF -β and BMP signaling; TGF -β = transforming growth factor- β. Available online http://arthritis-research.com/content/8/1/101 Abstract Osteoarthritis...

Ngày tải lên: 09/08/2014, 07:20

... atherosclerosis. TGF -β 1 is an inhibitor of smooth muscle and endothelial cell proliferation [8]. Mice heterozygous for the deletion of the TGF -β 1 gene (tgfβ 1 +/- ) have a 50% reduction in levels of TGF- β 1 ... patients and TGF -β 1 Activation Index are correlated, using Pearson test. PBMC, peripheral blood mononuclear cell; SLE, systemic lupus erythematosus; TGF, transforming growth factor. Arthritis ... 7 (page number not for citation purposes) Vol 8 No 3 Research article Activation of transforming growth factor- β 1 and early atherosclerosis in systemic lupus erythematosus Michelle Jackson 1 ,...

Ngày tải lên: 09/08/2014, 08:22

... 2 mRNA-expression of the transforming growth factor (TGF) -β related genesmRNA-expression of the transforming growth factor (TGF) -β related genes: (a) TGF -β1 , (b) TGF -β2 , (c) TGF -β3 , (d) TGF -β receptor 1 ... components of the transforming growth factor (TGF) -β pathway in RA SFBs, with 2 hits in the top 30 regulated pathways. The growth factor TGF -β1 , its receptor TGFBR1, the TGF -β binding proteins ... pronounced potency for further activation by the respective cytokines or growth factors, for example, transforming growth factor (TGF)- β. To enhance the significance of the array analysis, the mRNA data...

Ngày tải lên: 09/08/2014, 10:20

... regulators insulin-like growth factor (IGF)1 and transforming growth factor (TGF) -β [93,94] STC1 Stanniocalcin inhibits calcium uptake and has inhibitory effect on bone growth during development ... Transforming growth factor, beta receptor I -4.915 1.049 NM_000118 A ENG Endoglin 4.131 -2.461 NM_001105 BOBACVR1 Activin A receptor, type I 3.791 -0.941 NM_003573 LTBP4 Latent transforming growth ... 1.611 1.050 RUNX2 2.07 TGF -β/ BMP inducible/target genes AK001052 B OB FGFR1 Fibroblast growth factor receptor 1 4.234 1.993 NM_001553 A IGFBP7 Insulin-like growth factor binding protein 7 5.137...

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