targeting fibroblast growth factor receptor fgfr

... transfer and immunoblotting of FGFR isoforms FGF: fibroblast growth factor; FGFR: FGF receptor; qPCR: quantative polymerase chain reaction Figure 4: Activation of FGFR1 and FGFR3 by FGF-2 (A) Human ... Fibroblast growth factor receptor is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular ... following steps were performed as described above FGF: fibroblast growth factor; FGFR: FGF receptor Figure 5: FGFR expression profiles and FGFR3 regulation in articular chondrocytes (A) Age-matched,...

Ngày tải lên: 12/08/2014, 17:22

... the kinase domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, ... Mitsudomi T & Yatabe Y (2007) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in ... Sliwkowski MX (2006) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib...

Ngày tải lên: 16/02/2014, 09:20

... kinase inhibitors (TKIs) and triggered the development of this class of agents for targeting growth factor receptors frequently expressed in epithelial cancers [9] Two such inhibitors of the ... EGFR-TKI resistance is key References Mendelsohn J & Baselga J (2003) Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer J Clin Oncol 21, 2787–2799 Lenz ... EGFR Cancer Treat Rev 35, 262–271 Peeters M, Price T & Van Laethem JL (2009) Antiepidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today?...

Ngày tải lên: 16/02/2014, 09:20

... (2002) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 277, 27643–27650 10 Janmaat ML, Kruyt ... activation is critical for AG1478-induced apoptosis Herbst RS & Bunn PA Jr (2003) Targeting the epidermal growth factor receptor in non-small cell lung cancer Clin Cancer Res 9, 5813–5824 Nakagawa ... R & Bundred NJ (2001) ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFRpositive cancer cell lines with or without...

Ngày tải lên: 18/02/2014, 13:20

... the epidermal growth factor and nerve growth factor receptors J Biol Chem 271, 30505–30509 Browaeys-Poly E, Cailliau K & Vilain JP (1998) Fibroblast and epidermal growth factor receptor expression ... epidermal growth factor receptor ligands at a glance J Cell Physiol 218, 460–466 ´ 21 Villalobo A, Ruano MJ, Palomo-Jimenez PI, Li H & Martı´ n-Nieto J (2000) The epidermal growth factor receptor ... epidermal growth factor in epithelial LLC-PK1 cells Am J Physiol 265, C966–C975 29 Elliget KA, Phelps PC & Smith MW (1996) Transforming growth factor b modulation of the epidermal growth factor...

Ngày tải lên: 06/03/2014, 09:22

... cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor ⁄ extracellular signalregulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer Ther ... epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Res 65, 226–235 Prenzel N, Fischer OM, Streit S, Hart S & Ullrich A (2001) The epidermal growth ... Ono M & Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR -targeting drugs Clin Cancer Res 12, 7242–7251 18 Ioriol...

Ngày tải lên: 07/03/2014, 00:20

... remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive after ... REFERENCES Schlessinger, J & Ullrich, A (1992) Growth factor signaling by receptor tyrosine kinases Neuron 9, 383–391 Komada, M & Kitamura, N (1995) Growth factor- induced tyrosine phosphorylation of ... 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: differential intracellular routing and processing of ligand -receptor complexes Cell Regul 2, 599–612...

Ngày tải lên: 17/03/2014, 11:20

... epidermal growth factor receptor signaling Mol Syst Biol 1, 2005.0010 Kholodenko BN (2007) Untangling the signalling wires Nat Cell Biol 9, 247–249 Santos SD, Verveer PJ & Bastiaens PI (2007) Growth factor- induced ... EGFR mutation and MIG6 expression T Nagashima et al Introduction Epidermal growth factor receptor (EGFR) is a membrane tyrosine kinase that is involved in the regulation of a wide ... Haluska FG et al (2004) Activating 5250 15 16 17 18 19 20 21 22 23 mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med...

Ngày tải lên: 30/03/2014, 01:20

... implications of the ErbB/HER signaling network of growth factor receptors Adv Cancer Res 2000, 77:25-79 Diasio RB, Furie J: Targeting the epidermal growth factor receptor in the treatment of colorectal ... epidermal growth factor receptor by immunohistochemestry J Clin Oncol 2005, 23(9):1803-1811 Moroni M, veronese S, Benvenuti S, et al.: Gene copy number for epidermal growth factor receptor and ... 23 24 Prewett M, Hooper A, Bassi R, et al.: Enanched antitumor activity of antiepidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human...

Ngày tải lên: 18/06/2014, 16:20

... Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; NR, not reached; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; *overall ... VEGFR-3 Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor (B) FGF2 uPa ... extracellular matrix; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; MMP, matrixmetallo...

Ngày tải lên: 18/06/2014, 19:20

... Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; NR, not reached; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; *overall ... VEGFR-3 Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor (B) FGF2 uPa ... extracellular matrix; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; MMP, matrixmetallo...

Ngày tải lên: 20/06/2014, 04:20

... that this new delivery system can help tissue regeneration and wound healing by releasing the growth factors in a controlled and temporal manner Base a longer release period, around weeks [13] ... internalization of MSNs, indicating that the MSNs are not only a biocompatible delivery system for growth factors/ proteins, but also an ideal biomaterial for the application in bio-imaging Conclusions ... reported [24] In most cases, smaller nanoparticles offer prolonged releasing kinetics Other possible factors related to the releasing rate include the pore size and the properties of payload, and so...

Ngày tải lên: 22/06/2014, 00:20

... normoxia; (c) hypoxia) and presence ((b) normoxia; (d) hypoxia) of fibroblast growth factor (FGF2) Scale bar, 100 µm FGF2, fibroblast growth factor specific type II collagen gene promoter activity [35] ... tension (n = 3) *p < 0.05; **p < 0.001 (Student's unpaired t test) in cell aggregates from fibroblast growth factor (FGF2)-expanded versus non-FGF2-expanded cells P2, passage 2; P3, passage AGCTTCTGTGGAACCATGGAA-3' ... under hypoxia after 14 days in culture AGG, aggrecan; BGN, biglycan; DCN, decorin; FGF2, fibroblast growth factor 2; FMOD, fibromodulin; P2, passage 2; P3, passage Page of (page number not for citation...

Ngày tải lên: 09/08/2014, 07:20

... of epidermal growth factor receptors in meningiomas J Neurosurg 1997, 87(2):315-323 Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B: Distribution of epidermal growth factor receptor gene ... Macchia V: Epidermal growth factor receptor in human brain tumors J Endocrinol Invest 1992, 15(1):31-37 Johnson MD, Horiba M, Winnier AR, Artiaga CL: The epidermal growth factor receptor is associated ... Gregoriou M, Hughes JT: Epidermal Growth Factor Receptor expression in 72 meningiomas Cancer 1990, 66(1):152-155 Dorward NL, Hawkins RA, Whittle IR: Epidermal growth factor receptor activity and clinical...

Ngày tải lên: 09/08/2014, 09:20

... association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments Cancer ... transforming growth factor α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck Cancer 1996, 78:1284-1292 Baumann M, Krause M: Targeting the epidermal growth ... head and neck 10 RT: radiation therapy EGF: epidermal growth factor EGFR: epidermal growth factor receptor 11 TGF-α: transforming growth factor alpha 12 RTOG: Radiation Therapy Oncology Group...

Ngày tải lên: 09/08/2014, 10:20

... control FGF2, fibroblast growth factor 2; FGFR, fibroblast growth factor receptor Based on real-time PCR results, we found that FGFR1 , followed respectively by FGFR2 , FGFR4 , and FGFR3 , is the ... EO: Growth factor expression in degenerated intervertebral disc tissue An immunohistochemical analysis of transforming growth factor beta, fibroblast growth factor and platelet-derived growth factor ... proinflammatory cytokines and growth factors such as IL-1 [5,11,12] – and potentially fibroblast growth factor (FGF2) (otherwise known as basic fibroblast growth factor) [13] – both of which have...

Ngày tải lên: 09/08/2014, 10:23

... present in the IPFP tissue of fibroblast growth factor- 2 (FGF-2) expansion Chondrogenic cultures of infrapatellar fat pad (IPFP) cells and effects of fibroblast growth factor- 2 (FGF-2) expansion ... ascorbate 2-phosphate, 100 nM dexamethasone, 10 ng/mL transforming growth factor (TGF)-β3, and 100 ng/mL insulinlike growth factor- 1 (all from Sigma-Aldrich) Gene expression analysis Quantitative ... against the following: CD13 (aminopeptidase N), CD44 (hyaluronan receptor) , CD90 (Thy-1), LNGFR (low-affinity nerve growth factor receptor) , STRO1 (marker for bone marrow-derived stem cell), and...

Ngày tải lên: 09/08/2014, 10:23

... a growth factor, a proteoglycan, and a high-affinity fibroblast growth factor receptor (FGFR) , which is a transmembrane tyrosine kinase receptor [13] Four different highaffinity receptors (FGFR1 , ... III of FGFR1 to FGFR3 leads to distinct functional variants (IIIb and IIIc) that have different ligand-binding specificities and affinities FGF8 can bind to three receptors – FGFR2 IIIc, FGFR3 IIIc, ... different highaffinity receptors (FGFR1 , FGFR2 , FGFR3 , and FGFR4 ) bind FGF ligands and display varying patterns of expression [14] Extracellular domains of FGFRs consist of three immunoglobulin-like...

Ngày tải lên: 09/08/2014, 10:23

... M, Bunn PA Jr, Di Maria MV, Veve R, Bremmes RM, Baron AE, Zeng C, Franklin WA: Epidermal growth factor receptor in nonsmall-cell lung carcinomas: correlation between gene copy number and protein ... Fujiuchi S, Nishigaki Y, Ishida S, Nagase A, Miyokawa N, Hirata S, Kikuchi K: Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients ... Oncol Rep 2000, 7(3):603-607 Veale D, Ashcroft T, Marsh C, Gibson GJ, Harris AL: Epidermal growth factor receptors in non-small cell lung cancer Br J Cancer 1987, 55(5):513-516 Miller VA, Kris MG,...

Ngày tải lên: 10/08/2014, 05:21

... transforming growth factor- alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters Brain Research 2005, 1038:171-182 Wakefield LM, Yang Y, Dukhanina O: Transforming growth factor- beta ... JA, Chetty R, Burgess AW, Dunn AR: A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on the receptor biochemistry that results in impaired lactation Proceedings ... KE, Amann V, Threadgill DW: Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and...

Ngày tải lên: 10/08/2014, 09:20