f hepatic steatosis nash and related conditions
Fatty Liver Disease: NASH and Related Disorders ppt
... NAFLD and especially NASH is important, and clarify which affected persons are the ones we need to worry most about NAFLD /NASH is common, expensive to society, adversely affects quality of life ... X), but the factors that transform steatosis to NASH remain unclear NAFLD /NASH is the most common type of liver disease in affluent societies, affecting between and 8% of the population NASH typically ... not sufficient to warrant a diagnosis of NAFLD /NASH types 2– Nor does the existence of one or more clinical risk factors for NASH justify the designation of simple fatty Table 2.1 Grading of steatosis...
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Báo cáo y học: "Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions" doc
... yet other, unidentified, factors) of bradykinin -related pathways occur, multiple different mutations can occur in each factor, and it seems likely that different combinations of these mutations ... secondary effects of the relative bioavailability of estrogen) outweigh the effect of increased factor XII However, this observation has intriguing consequences for HAE-FXII In this situation, androgen-induced ... to significant hormonal effects Autosomal dominant transmission seemed likely in a French pedigree [3] The recent identification heterozygosity for a gain-of-function mutation in F1 2 in female...
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Fatty Liver Disease : Nash and Related Disorders - part 1 ppt
... and/ or hepatic fibrosis It comprises a pathogenic link in the chain of NAFLD that extends from bland steatosis to some cases of ‘cryptogenic cirrhosis’ NAFLD and NASH are usually hepatic manifestations ... not sufficient to warrant a diagnosis of NAFLD /NASH types 2– Nor does the existence of one or more clinical risk factors for NASH justify the designation of simple fatty Table 2.1 Grading of steatosis ... degree and type of inflammation [45] NASH- associated cirrhosis, ‘cryptogenic’ cirrhosis and recurrence of NAFLD /NASH after liver transplantation Effects of treatment The reversibility of steatosis...
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Fatty Liver Disease : Nash and Related Disorders - part 3 potx
... storage and export of hepatic triglyceride will clearly influence the magnitude of steatosis and the risk of NASH SCD-1, which converts saturated FFA to monounsaturated FFA, is critical for the hepatic ... Change Suppression of serum (FFA) Suppression of serum (glycerol) -50 -100 Normal Fatty liver NASH Fig 7.2 Serum FFA and glycerol in subjects with fatty liver or NASH and in age- and gender-matched ... acids (FFA) in the pathogenesis of non-alcoholic steatohepatitis (NASH) Expanded central adipose tissue leads to the release of FFA and TNF-α into the portal circulation The release of FFA is...
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Fatty Liver Disease : Nash and Related Disorders - part 4 pot
... phenotype is hepatic steatosis with no inflammation The mechanism of steatosis is related to increased delivery of FA to the liver (serum triglycerides and FFA levels are increased) and enhanced hepatic ... epidemiological and pathophysiological relationship to NASH 109 CHAPTER Fig 9.1 Schematic of free fatty acid (FFA) flux The liver receives fatty acids from endogenous synthesis (lipogenesis) and import from ... Normal hepatic fatty acid metabolism Long-chain free fatty acids (FFA) dissociate from albumin in the space of Disse and cross the liver cell plasma membrane In the cell, FFA are bound to liver fatty...
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Fatty Liver Disease : Nash and Related Disorders - part 5 pdf
... increases plasma free fatty acids (FFA) and hepatic FFA uptake Insulin resistance in myocytes increases glucose and/ or insulin levels, which may increase hepatic FFA synthesis Hepatic FFAs are increased ... (with or without NASH) , this new equilibrium is achieved at the expense of expanded pools of hepatic FFA and triglycerides, thus causing steatosis (Fig 11.1) [3] Harmful effects of fat in the liver ... (Fas L) and TNF-α The latter is also formed by the adipocytes of obese subjects and by endotoxin-stimulated Kupffer cells The interaction of Fas L with Fas, or TNF-α with TNF-α receptor (TNFR1),...
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Fatty Liver Disease : Nash and Related Disorders - part 6 docx
... were 30 IU/L for men and 19 IU/L for women [4] Using the above revised cutoffs for ‘abnormal’ ALT, Ruhl and Everhart [3] found the prevalence of presumed NAFLD to be 12% for men and 14% for women ... reduction an effective therapy for non-alcoholic fatty liver? A systematic review Am J Med 2003; 115: 554–9 44 Andersen T, Gluud C, Franzmann MB, Christoffersen P Hepatic effects of dietary weight ... recognition of advanced NASH in younger patients and the often uncertain effects on the liver of medications used for comorbid conditions, these observations indicate a need for greater awareness and...
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Fatty Liver Disease : Nash and Related Disorders - part 7 ppsx
... Simmons F, Murphy J Effect on hepatic morphology of treatment of obesity by fasting, reducing diets, and small bowel bypass N Engl J Med 1970; 282: 829–34 Palmer M, Schaffner F Effect of weight ... of hepatic steatosis and the metabolic syndrome both before and after liver transplantion Abstract Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) aa severe form ... overproduction of TNF, alteration of hepatocyte ATP stores and CYP2E1 and 4A enzyme activity may have a role in the genesis and progression of NAFLD Regardless of the cause, acute or chronic hepatic steatosis...
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Fatty Liver Disease : Nash and Related Disorders - part 8 potx
... steatosis, hepatic fibrosis, cirrhosis Steatosis, Mallory bodies NAFLD /NASH NAFLD, cirrhosis NAFLD NAFLD ?NAFLD /NASH Steatosis, hepatitis, cirrhosis, hepatic failure NAFLD /NASH Elevated ALT, steatosis, ... mimic the clinical and pathological features of NAFLD and present with hepatic steatosis or NASH The pathogenesis of these conditions may be quite different from NAFLD that results from metabolic ... developed for adults [11] Adult NASH histology differs from paediatric NASH histology, particularly with regard to the extent and location of hepatic inflammation and fibrosis For the purposes of this...
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Fatty Liver Disease : Nash and Related Disorders - part 10 pdf
... genetics 67 family history cryptogenic cirrhosis 176 NAFLD /NASH 160–161 Fas-Fas ligand interaction 139–140 Fas ligand expression, reactive oxygen species 139 fasting acetyl-CoA 133 free fatty acid ... inhibitors of metalloproteinases 145, 146, 152 F fa/fa rat 95, 99 liver regeneration 154, 155 fak/fak Zucker rat 99 familial partial lipodystrophy 250, 253–254 family-based studies, NAFLD /NASH genetics ... severity of NASH) (P < 0.001 for all) Initial liver biopsies revealed NASH in 23 patients and simple steatosis in 12, while only four follow-up biopsies fulfilled the histological criteria for a diagnosis...
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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... Histological features of HBeAg-negative CHB patients with and without steatosis Number Steatosis F0 F1 F2 F3 F4 Inflammation activity G0 G1 G2 G3 Fibrosis stage S0 S1 S2 S3 S4 CHB with steatosis ... hematoxylin-eosin-safran and Masson's trichrome Hepatic steatosis, stage of fibrosis and grade of disease activity were determined according to the Guidelines for the assessment and management of non-alcoholic fatty ... titer and curative difficulty, and thus hepatic steatosis will definitely increase the difficulty of therapy in HBeAg-negative HB patients (13) In comparison to HBeAg-negative CHB with hepatic steatosis, ...
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Báo cáo y học: "Hepatitis C Virus (HCV) Infection and Hepatic Steatosis"
... clinically significant relationship between HCV infection and hepatic steatosis Two forms of steatosis exist in our patients with HCV The first type of steatosis occurs secondary to metabolic factors ... severity of steatosis and the extent of fibrosis on liver biopsy specimens However, the majority of studies to date have not separated the two types of steatosis when examining its affects on fibrosis ... cytopathic effect of hepatitis C virus genotype J Hepatol 2000;33:106-15 24 Hezode C, Roudot-Thoraval F, Zafrani ES, et al Different mechanisms of steatosis in hepatitis C virus genotypes and infections...
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DIVISION F—DEPARTMENT OF THE INTE- RIOR, ENVIRONMENT, AND RELATED AGEN- CIES APPROPRIATIONS ACT, 2008 pptx
... the provisions of the Fish and Wildlife Act of 1956 and the Fish and Wildlife Coordination Act, for the development and implementation of programs for the benefit of wildlife and their habitat, ... of the Office of the Solicitor, $59,250,000 OFFICE OF INSPECTOR GENERAL SALARIES AND EXPENSES For necessary expenses of the Office of Inspector General, $44,572,000 OFFICE OF SPECIAL TRUSTEE FOR ... revested Oregon and California Railroad grant lands, on other Federal lands in the Oregon and California land-grant counties of Oregon, and on adjacent rights-of-way; and acquisition of lands or interests...
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food neophobia among the finns and related responses to familiar and unfamiliar foods
... willingness to try foods, 2-way analysis of variance, F ratios (df for familiarity=1; for FNG=2; for Familiarity  FNG =2; residual= 1077) Food Familiarityb FNGb Familiarity  FNGb Familiar foods Smoked ... unfamiliar For four foods Ð pineapple, strawberry yogurt, beef tomato, and snails Ð the eect was further quali®ed by interaction between familiarity and FNG For LoR chocolate bar and for tofu, ... percentage of subjects who had tasted the food stimuli (Table 3) Seven foods in the group of familiar foods and six foods in the group of unfamiliar foods had been tried signi®cantly more often by...
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Basics of PLCs and related s7200
... TD400C DEL Simatic OP 73micro Value 49 TAB 50 F1 F9 F1 F1 0 F2 F1 1 F3 F1 2 F4 F1 3 F5 F1 4 F6 F1 5 F7 F1 6 F8 F2 100 F3 F4 +/- ACK SHIFT ENTER ESC SHIFT HELP ESC Tank INS ENTER OP 73micro TD 400C Text ... easy to implement solutions for a variety of display needs F1 F2 ESC TOUCH TD 100C SIMATIC PANEL ENTER TD 100C TD200 F5 F1 F7 F3 F6 F2 F8 F4 SHIFT ESC ENTER TD 200 and TD 200C TP 177micro TD400C ... power of based on its position in the number The further to the left, the higher the power of The number in the far left-hand column is referred to as the most significant bit or MSB and the...
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Tài liệu TRAFFIC SAFETY AND ROAD CONDITIONS docx
... resource development on traffic safety, a study on traffic accidents for model area in Hanoi, preparing and broadcasting of traffic safety TV drama and Hanoi traffic safety improvement project ... years of experience in VN, was invited to present traffic safety situation Vietnam Contents of the presentation include basic data on traffic accidents, problems and issues of traffic safety in ... Beverages and Traffic Accidents'', the conference aimed to educate traffic officials about the new law on wearing protective helmets and the consequences of driving under the influence of alcohol...
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Tài liệu Part III: EXTENSIONS AND RELATED METHODS pdf
... contrast function of the form (15.9), where the direct estimation of the statistics E fG(wT v)g of the noise-free data is made (k) (k) possible by using G(u) = 'c (u) We call the statistics of the form ... nonquadratic function, and is a standardized gaussian variable Such a measure could be used for noisy data as well, if only we were able to estimate JG (wT v) of the noise-free data from the noisy ... a better approach could often be to reduce noise in the data before performing ICA For example, simple filtering of time-signals is often very useful in this respect, and so is dimension reduction...
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INFERTILITY AND RELATED ISSUES
... inseminations offers some hope short of IVF If the former is unsuccessful, IVF should be offered PSYCHOLOGIC ASPECTS OF INFERTILITY Infertile couples need considerable psychologic support Infertility ... INFERTILITY AND RELATED ISSUES (SPECIAL FERTILITY PROCEDURES, HYPERANDROGENISM) INFERTILITY Infertility is defined as the failure to conceive after one year of attempting pregnancy Primary infertility ... 30%, and a female fetus is at risk of virilization HYPERANDROGENISM OF ADRENAL ORIGIN Excess androgens from the adrenal glands may be the result of neoplasia, inborn errors of biosynthesis of adrenal...
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Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... potential for ibuprofen as an effective intervention Ibuprofen and Amyloid Reduction In our initial efforts to determine a mechanism for the impact of ibuprofen on amyloid we ruled out effects on ... controlling inflammation and oxidative damage and promoting CNS lesion ‘healing’ Because of the strong preclinical safety and broad-spectrum efficacy data and identified structure, we chose to first ... A peptide for understanding the pathological process of AD Except for unusual conditions, all pathological AD mutants of PS and APP affect the precision of the ␥-cleavage site of APP [1],...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... abundant expression of mRNA for the GDNF receptor, GFRa1, in SNpc, and for the signaling tyrosine kinase Ret as well, offers further support for GDNF as a possible neurotrophic factor for developing ... modulation of 15–30 Hz coherence between rectified EMGs from human hand and forearm muscles J Physiol 516(Pt 2): 559–570 Kristeva-Feige R, Fritsch C, et al (2002) Effects of attention and precision of exerted ... perhaps resulting from the fact that different limbs of parkinsonian patients may engage in tremor of different frequencies (Bergman et al., 1998), making it difficult to identify a ‘causative’...
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