[...]... The Editors Fatty Liver Disease: NASH and Related Disorders Edited by Geoffrey C Farrell, Jacob George, Pauline de la M Hall, Arthur J McCullough Copyright © 2005 Blackwell Publishing Ltd 1 Overview: an introduction to NASH and related fatty liver disorders Geoffrey C Farrell, Jacob George, Pauline de la M Hall & Arthur J McCullough Key learning points 1 Non-alcoholic steatohepatitis (NASH) is a form... conference First European and Japanese single topic conferences NASH established as part of insulin resistance syndrome Release of first book on NAFLD /NASH Fig 1.1 Chronology of the pace of research into pathogenesis, natural history and treatment of NAFLD /NASH INTRODUCTION TO NASH AND RELATED DISORDERS Table 1.1 Categories of non-alcoholic fatty liver diseases (NAFLD): relationship to NASH (After Matteoni... after liver transplantation Hepatic steatosis as a cause of primary graft non-function after liver transplantation Role of metabolic determinants of NASH in pathogenesis of other liver diseases, particularly hepatitis C and alcoholic cirrhosis Possible role of NASH/ hepatic steatosis in hepatocarcinogenesis 4 INTRODUCTION TO NASH AND RELATED DISORDERS The NASH epidemic In much of the world, abnormal liver. .. 2001; 344: 1343–50 Fatty Liver Disease: NASH and Related Disorders Edited by Geoffrey C Farrell, Jacob George, Pauline de la M Hall, Arthur J McCullough Copyright © 2005 Blackwell Publishing Ltd 2 Pathology of hepatic steatosis, NASH and related conditions Pauline de la M Hall & Richard Kirsch Key learning points 1 Non-alcoholic steatohepatitis (NASH) is the term used to describe liver injury that occurs... Childhood cases of NASH are also clearly related to obesity and type 2 diabetes (see Chapter 19) [46,47] Some possible reasons for high rates of obesity and type 2 diabetes in contemporary affluent societies (‘east’ and ‘west’, ‘north’ and ‘south’), and the implications for prevention and interruption of NASH are discussed in Chapters 3–5 and 18 Chapter 3) However, 20–25% of cases with NASH have or will... steatohepatitis (NASH) : a disease of emerging identity and importance J Hepatol 1998; 29: 495–501 10 15 Matteoni CA, Younossi ZM, Gramlich T et al Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 1999; 116: 1413–9 16 Angulo P Non-alcoholic fatty liver disease N Engl J Med 2002; 16: 1221–31 17 Younossi ZM, Diehl AM, Ong JP Non-alcoholic fatty liver disease:. .. alcoholic liver disease and chronic hepatitis C as reason for referral to gastroenterologist or liver clinic NASH is a potential cause of cirrhosis, which may be ‘cryptogenic’, and lead to end-stage liver disease Liver failure is most common cause of death in patients with cirrhosis resulting from NASH Standardized mortality of liver disease in type 2 diabetes greatly exceeds vascular disease NASH recurs... Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 1999; 116: 1413– 9 14 Mulhall BP, Ong JP, Younossi Z Non-alcoholic fatty liver disease: an overview J Gastroenterol Hepatol 2002; 17: 1136–43 15 Cairns SR, Peters T Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects Clin Sci (Lond) 1983; 65: 645–2 16 Wanless IR, Lentz JS Fatty liver. .. estimates, and are now in the range 17–33% for NAFLD and 5.7–17% for NASH 3 This increase and high prevalence is related to societal changes in obesity and genetic factors 4 In some population-based surveys, hepatic steatosis is more strongly associated with obesity than heavy alcohol use 5 NASH is a progressive fibrotic disease, in which cirrhosis and liver- related death occur in up to 20% and 12%, respectively,... 17–33% for NAFLD and 5.7–16.5% for NASH Because NAFLD and NASH are associated with insulin resistance and obesity, these prevalence rates are expected to increase worldwide, concurrent with the pandemic epidemic of obesity and type 2 23 CHAPTER 3 diabetes The importance of these observations stems from the fact that NASH is a progressive fibrotic disease, in which cirrhosis and liver- related death occur . alt="" Fatty Liver Disease: NASH and Related Disorders Fatty Liver Disease: NASH and Related Disorders Edited by Geoffrey C. Farrell Director, Storr Liver. (dietary measures and increased physical activ- ity) is a logical approach to prevent or reverse NAFLD /NASH. Fatty Liver Disease: NASH and Related Disorders Edited