collagen network regulation of mmps and timps and effects of cytokines
Regulation of cytokines by small RNAs during skin inflammation potx
... here on the regulation of cytokines at the RNA level in relation to development of inflammatory disease We provide an overview of the network of cytokine signaling in psoriasis and its regulation ... administration of anti-IL20 antibodies leads to resolution of psoriasis [40] Regulation of the cytokine network at the RNA level The regulation of cytokine production is the very foundation of the innate ... assemblies of mRNAs and components of the RNA decay and silencing machinery [53] TNFα mRNA is the most studied target of TTP, but a series of other cytokines, including IL-6, IL-10, IL-12, and granulocyte-macrophage...
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Homoeostatic regulation of cytokines to retard liver fibrosis 1
... accepted for the treatment of liver fibrosis Better understanding of the mechanism of action of HGF and development of a robust delivery method that can address the risk of hepatocarcinogenesis ... pathogenesis of fibrosis Activated HSCs (Fig 7) are at the center of fibrogenic activity, and in addition to synthesizing the components of ECM, they also produce MMPs and TIMPs Myofibroblasts ... Validation of the pDsRed2-HGF construct in HEK-293T cells Figure 23: Evaluation of the anti-fibrotic effects of VALH particles in HSC-T6 cells Figure 24: Evaluation of the anti-fibrotic effects of VALH...
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Homoeostatic regulation of cytokines to retard liver fibrosis 2
... suppression of TGF-β1 gene expression (71); inhibition of α-SMA production, stimulation of apoptosis in activated HSCs (72,78), and inhibition of collagen I, III synthesis and promotion of collagen ... apoptosis and a drastic decrease in plasmin levels (84,123-125) Plasmin has a variety of anti-fibrotic effects, aiding the degradation of ECM proteins (84,126), and activating MMPs The effect of plasmin ... anti-fibrotic effects of HGF in hepatocytes were negated or strengthened by simultaneous effects of HGF in HSCs Our study investigated a two-fold mechanism of HGF-induced regulation of TGF-β1 activation...
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Homoeostatic regulation of cytokines to retard liver fibrosis 3
... mechanisms of the anti-fibrotic effects of HGF provides a better understanding of the intricate regulation of cytokines and growth factors during fibrosis and how the restoration of homeostasis ... number of activated myofibroblasts that create a concentrated centre of pro-fibrotic cytokines such as TGF-β1 and accumulation of ECM proteins such as Collagen I HSCs are one of the major sources of ... mechanism of regulation of active TGF-β1 by HGF We now understand that the anti-fibrotic effects of HGF on HSC activation are primarily due to a decrease in TGF-β1 activation The mechanism of action of...
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Homoeostatic regulation of cytokines to retard liver fibrosis 4
... 5.1 ROLE OF TGF-β CO-REPRESSOR SnoN DURING THE HGFDEPENDENT INHIBITION OF TGF-β1 ACTIVATION As seen in Chapters and 2, TGF−β signaling plays a very important role in the activation of HSC and fibrosis ... target and antagonize TGF−β signaling have been researched upon extensively leading to the knowledge of activators of the signaling at the transcriptional/protein level and repressors of the ... levels of naïve control rats (Fig 40) demonstrating the HGF-based up -regulation of SnoN even in animal models of fibrosis Additionally, the HSC-targeted delivery appeared to have higher levels of...
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Understanding the regulation of cytokinesis in fission yeast
... in cytokinesis 14 Temporal regulation of cytokinesis 19 1.3.2.1 Cell cycle regulation of cytokinesis in metazoans 19 1.3.2.2 Cell cycle regulation of cytokinesis in fission yeast 21 Spatial regulation ... regulation of cytokinesis 23 1.3.3.1 Positioning of division plane in metazoans 23 1.3.3.2 Positioning of division plane in fission yeast 26 1.3.3.3 Morphogenesis and spatial regulation of cytokinesis ... broad band of cortical proteins instead of a single nucleation site/spot, and the assembly process is stochastic and dynamic 1.3.1.3 Signaling pathways involved in cytokinesis Regulation of RhoA...
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Regulation of cytokinesis in the fission yeast schizosaccharomyces pombe
... these instructive early studies Marshland and Landau (Marsland and Landau 1954) when studying the effects of temperature and pressure on the cleavage of eggs of various animals proposed that the ... a relatively simple model of more complex eukaryotes and has been of crucial importance in our understanding of the mechanisms of cell cycle control Interestingly, of the approximately 5000 genes ... understand the complex regulation of genetic networks and the consequences of their mis -regulation Beginning with Nurse’s pioneering work on the cell cycle (Nurse et al 1976), a number of genetic screens...
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Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
... collagen I synthesis and breakdown clearly indicate an important role for ET-1 in the dynamic regulation of ECM and its dysregulation in disease [19] ET-1 and its isoforms ET-2 and )3 belong to a ... effect by inhibiting PLC-b (Fig 5A), strong down -regulation of collagen I levels after inhibition of PC-PLC (Fig 5B), and similar collagen I down -regulation after PLD inhibition (Fig 5C) These ... expression of fibronectin and collagen and their incorporation into extracellular matrix J Biol Chem 261, 4337–4345 43 McAnulty RJ, Chambers RC & Laurent GJ (1995) Regulation of fibroblast procollagen...
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Báo cáo y học: "Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4" pot
... http://arthritis-research.com/content/11/5/R158 Figure Degree of tissue inflammation and bone and cartilage destruction in the absence of endogenous Th1 and Th2 cytokines (a and b) Tissue sections cytokines of arthritic hind paw from ... protective effects on bone and cartilage damage, independent of regulation of IL-17 Intra-articular delivery of adenoviral vector associated Th2 cytokines, IL-4 and IL-13, has been shown to slow bone and ... protective and pathogenic roles in CIA, depending on the stage of disease, location of IL-4 production and relative abundance of other cytokines This suggests that in vivo the balance of IFN-γ, IL-4 and...
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Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... the reduced production of collagen when fibroblasts are stimulated by TGF-β in the presence of PI Differential effects of proteasome inhibition and TGF-β on MMP-1 and MMP-2 MMPs play a major role ... 1211 Geneva 14, Switzerland and 2Department of Pathology and Immunology, Geneva University Hospital and School of Medicine, rue Michel Servet 1, 1211 Geneva 14, Switzerland 19 Received: 10 December ... M, Mrozikiewicz A, Baumann G, Stangl K: Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome Hypertension 2004, 44:471-477...
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Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice
... 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of ... owner of a vessel registered with a state party and carrying over 2,000 tons 87 88 89 90 91 92 94 95 See Arts 1(4), and 7(4) of the NSR Regulations; Art 14 of the Economic Zone Edict; and Art of ... shall establish periods and areas closed for navigation, and also other measures ensuring the safety of shipping and the prevention, reduction, and control of pollution of the marine environment...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... Scientific Fund of the Ministry of Education, Science and Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation ... few have focused upon the role of miRNAs in regulatory network of various cell signaling pathways We summarize the current knowledge of the interdependence of miRNA and cell signaling pathways, ... complicated networks for the regulation of the transcriptome Current findings on the role of miRNAs in cardiac diseases [11] and recent discoveries involving the miRNA–epigenetics regulatory network...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... reduces the affinity of 14-3-3 for Bax and Bad and translocation of Bax and Bad to mitochondria independently of caspase activation [77,87] Phosphorylation of caspases Phosphorylation of caspases switches ... apoptotic signal on and off Caspase activation is under the direct control of kinases and phosphatases, and the indirect control of phosphorylation through the regulation of other apoptotic proteins ... activity of an isoform of PP1, PP1a [3] Similarly, activation of caspase-8 and -3 is regulated through their phosphorylation and dephosphorylation Phosphorylation of caspase-8 at Tyr397 and Tyr465...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene ... and had no expression of the chondrocytic markers type II collagen, type IX collagen, type X collagen, and aggrecan Besides type II collagen and aggrecan, Sox9 also regulates the expression of ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... cholesterol-enriched microdomains of the plasma membrane (caveolae), intracellular organelles, ligandindependent activation of growth factor- and cytokine receptors and autocrine stimulation of signal transduction ... metabolism and proliferation and provides cytoprotection, whereas cellular shrinkage leads to catabolism and insulin resistance and sensitizes cells to apoptotic stimuli The influence of cell volume ... activation of the p38-type MAPK and thereby inhibition of 5800 autophagic proteolysis [14] Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin...
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Tài liệu Báo cáo khoa học: Redox regulation of dimerization of the receptor proteintyrosine phosphatases RPTPa, LAR, RPTPl and CD45 pdf
... for the effects of oxidation and acts as a redox sensor [8,13,32] Oxidation of RPTPa-D2, like PTP1B, results in the formation of cyclic sulfenamide at the catalytic site, which is stable and reversible ... et al Redox regulation of RPTPs A B C D Fig Dimerization of LAR, RPTPl and RPTPa COS-1 cells were transiently co-transfected with (A) HA-tagged and ⁄ or Myc-tagged LAR, (B) HA-tagged and ⁄ or Myc-tagged ... of the cytoplasmic domains of these RPTPs These results suggest there is flexibility in the cytoplasmic domain of RPTPs, and are evidence against rigid conformations that prohibit regulation of...
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Tài liệu REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL doc
... to Article 291 of the Treaty on the Functioning of the European Union and in accordance with Article 15 of Regulation (EU) No 1095/2010 of the European Parliament and the Council of 24 November ... Parliament and of the Council of 18 December 2000 on the protection of individuals with regard to the processing of personal data by the EU institutions and bodies and on the free movement of such ... except for paragraph of Article and paragraph of Article 8, which shall apply from the date of entry into force of this Regulation This Regulation shall be binding in its entirety and directly applicable...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... via increased transcription and/ or by stabilization of the CTGF transcripts and the role of RhoA GTPase and p38 signaling in such a regulation, nuclear run-on assays and message stability analyses ... shown) The pharmacological effects of these drugs are only partially understood, and some of their unknown effects may affect gene expression as well physiologic states of G-actin monomers within ... probably reflects the dual specificity of MKK4 for both p38 and JNK1/2 Meanwhile, because p38 is a potential downstream target of RhoA and Cdc42, we examined the effects of SB-203580, a p38 inhibitor...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... at 50 °C and 10 at 95 °C, followed by a total of 40 twotemperature cycles (15 s at 95 °C and at 60 °C) For the generation of standard curves, serial dilutions of a cDNA sample were used and mRNA ... by 30 at 48 °C and a final step of at 95 °C and 20 ng of cDNA was used per reaction in quantitative PCR Specific iPLA2c primer pairs and probe were designed using PRIMER EXPRESS software from PE...
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Tài liệu Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation pdf
... mechanism of regulation of both domains involves a common iron dependent process [74,75,79] Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... tumours of oxygen and nutrient supply Coupled with previous studies that have provided Ôproof of principleÕ that targeting HIF stability [111] and transactivation [78] can enhance oxygen delivery and ... protein hydroxylation? Apart from the HIF pathway and HIFa subunits, the regulation and activity of a large number of other cellular processes and proteins have also been demonstrated to be influenced...
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