... the enzymes of amphibians as they evolved into reptiles. Thermal stability of the enzyme might be evaluated as one ofthe factors thatreflect the DNase I activity levels in vivo [13].Asalackof,ordecrease ... enzymes, but close to mammalian and avian DNases I.Thermal stabilities of wild-type and substitutionmutant snake DNases I The thermal stabilities ofthe wild-type and mutantenzymes ofthe snakes were ... cell turnover and thus for the prevention of systemic lupus erythematosus (SLE) [12]. The gene product of human DNASE1*6 was morethermally unstable than that ofthe other alleles and subjects...
... tạo ra phân xanh cho cây trồng. Ví dụ ở Rwanda, nông dân không cắt tỉa cây vào những thời điểm mà các nhà nghiên cứu đã đưa ra, mà cắt lá cây theo lịch riêng của họ và cho dê ăn lá cây. ... phần kĩ thuật này vào hệ thống canh tác. Kĩ thuật đáng lẽ được áp dụng từng phần, thay đổi tuỳ theo nhu cầu của nông dân và kĩ năng quản lý và hưởng lợi từ kĩ thuật đó. Một ví dụ tốt là kĩ ... nông nghiệp và tài nguyên thiên nhiên và phát triển nông thôn. Từ năm 2003, Cơ sở môi trường to n cầu (GEF) đã sáng lập ra một chương trình tác nghiệp mới (OP 15) cho Quản lý đất đai bền...
... from NF-Y and p300. Forefficient activation ofthe promoters, the distance between the CCAAT-boxes has to be 31 to 33 bp, probably to allow binding of the p300 co-activator. In G0 and G1phases, ... alteration of the CDE [37]. Interestingly, the core ofthe human Tome-1promoter CDE⁄ CHR has a sequence identical to the tandem element in the human Cdc25C promoter [10].Recently, the mitosis-related ... transcription of thesecell cycle genes is repressed by a complex of inhibitory proteins at the CDE ⁄ CHR. It was shown that E2F4 binds tothe CDE and thatLin-54 binds tothe CHR in the Cdc2 promoter...
... system, rule of law, and corruption index). SIZE is the book value of total assets at the end ofthe fiscal year (in EUR thousands). We use the natural log ofthe size variable in the analysis. ... small profit (small loss) if positive (negative) net income falls within the range of one percent of lagged total assets. EM2 is the median ratio ofthe absolute value of total accruals tothe absolute ... we benchmark the variability of operating earnings to the variability ofthe cash flow from operations. Specifically, the measure is computed as the ratio ofthe standard deviation of operating...
... settings and using other nonexplora-tory procedures; an aim that we consider to be of great importance for research in this field.Another ofthe goals ofthe present study was to explore the role ... is to establish categories of urban landscapes on the basis of users’ aesthetic judgements. It also explores the role that the restorativecapacity of a place—in terms ofthe attentional restoration ... users. The results of such studiesshow that one ofthe underlying dimensions of perceptual differentiation is related tothe ‘‘extent of human intervention’’; in other words, the extent to which the...
... operating at varioussteps in the cytotoxic activity ofthe drug, from adecrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance. Oftenseveral different ... cells. Therefore, the promoter sequence of MDR-1 ()136 to 10) wasamplified, andthe luciferase reporter assay wasperformed to investigate the transcriptional regulation of P-gp by PI3K/Akt. The ... SGC7901/PrPCwasdecreased to levels similar tothe controls because of their toxicity in cell death (P > 0.05). The effects of LY294002 on adriamycin accumula-tion and retention in SGC7901/PrPCcells were furtherdetermined...
... attempt to establish theimportanceof GSK3 in the acute regulation of glucose transport in terms of itsregulatory control of GS in muscle and fat cells we haveinvestigated the effects of Li andthe ... effects of insulin is to promote the uptake, metabolism and storage of glucose inadipose tissue and skeletal muscle [1]. The hormonalregulation of these cellular processes is initiated by the binding ... cell system we compared the effects ofthe maleimide on the phosphorylation of PKB and GSK3 and upon the stimulation of glucose transport inresponse to a submaximal and maximal insulin concentra-tion....
... think of as the mind, is actually a composite ofthe physical and chemical states within neurons, the cells ofthe brain. Andto make matters more complicated, we know the brain is part ofthe ... indebted to Albert J. Stunkard, M.D., Professor of Psychiatry, and founder and Director Emeritus ofthe Center for Weight and Eating Disorders at the University of Pennsylvania School of Medicine—who ... (Pai and Paloucek 2000). Further, the 1979 version ofthe Metropolitan tables included 10% who self-reported their weights and heights rather than having had them accurately measured, and of the...
... Figure 1.) The objectives of audits ofthe government sector are different from those of audits ofthe private sector, and therefore, it is impossible to apply the International Standards on ... stage of development of ISAs, and achieve a convergence of such standards. To materialize their agreement, the Committee on Auditing Standards of INTOSAI (integrated into the Professional Standards ... preparing and submitting tothe parliament financial reports on the stock. The government sector s financial reports on the flow andthe stock are used by the parliament to evaluate how well the government...
... considered bottom four to consumers; not highly regarded by Marketing Professionals either 13 Professions Valuable to Society Q1. Which profession provides the most value to society? Top 2 Box ... Advertising/Marketing professionals considered in the bottom professions among consumers – along with actors and dancers; not highly regarded by marketing professionals either 9 Most marketing is a bunch of B.S., ... are the two most preferred places to look at an ad 2 Majority of respondents use social media; over half have liked on behalf of their favorite brands, but also wish there was a dislike button...
... preventing the sorption of Pb onto asandy soil (Jordan et al., 1997).Further analysis ofthe data reveal that the presence of Cu and Pb in the water extracts can be more precisely asso-ciated with the ... soils, the partitioning of FA and HA corre-lates with the system equilibrium pH. The partitioning of FA and HA as a function of pH varies widely for the soilsstudied. The Kd-OCvalues for FA and ... from the solid phase to solution in 18 Dutch soils. The main objectives of this studyare to (1) fractionate the DOC in water extractions of the soils, (2) examine the concentrations ofthe operationallydefined...
... overex-pression [29,30]. The aim ofthe present study was to provide a betterunderstanding ofthe contribution of Glc6P to the metabolic effects of glucokinase overexpression inhepatocytes andto test for ... inhibitor of Glc6P hydrolysis [31],for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content andthe rate of glycogen synthesis inhepatocytes ... synthesis. Based on the results ofthe presentstudy, it is suggested that the regulatory strength of glucokinase activators on glycogen metabolism canbe predicted from the magnitude of their...
... Quantitation ofthe inten sity of monomer and d imerbands. The data has been normalized as above. (C) The effect of 30 lMZn2+on the Pi-phosphorylation ofthe wild-type andthe P401Lenzymes ... possible that the tolerance for the s ubstitutions at this siteis related tothe size and hydrophobicity ofthe substitutingside chain. Inspection of a theoretical model of the Ca-ATPase in the E2state ... than the wild-type both in the absence a nd in the p resence of Fig. 3. Normalized zinc-dependent ATPase activity ofthe wild-type and mutated enzymes. TheATPaseactivity(percentageoftheactivityofthewild-type)...
... net synthesis of glycogenor the combination of both. The rates of total glycogen synthesis and 13Clabelincorporation into glycogen (Fig. 5) suggest that the overall rate of glycogen synthesis ... the initial rate of label incorporationinto glycogen C6 relative tothe rate of label incorporationinto glycogen C1 reflects the relative isotopic enrichment of Glc6P in the C6 relative tothe ... isotopicenrichments of glycogen C1 and C6, andthe net glycogensynthesis rate were measured, Eqns (1), (2) and (3) can berearranged to determine Vsyn and the isotopic enrichment of Glc6P in terms of Vphosas:ẵ13Glc6P1ẵGlc6Ptịẳdẵ13Glyc1dttịỵVphosẵ13Glyc1ẵGlyctịVnetỵ...
... probability and impact factors. The probability factors relate tothe likelihood ofthe event happening andthe impact factors indicate the scale and significance of the problem were it to occur. ... regulators. But the dangers lie in mechanistic and tokenistic application of these practices, their potential undermining of other public sector values andthe real danger that they may be used to ... collection of regulators brought together to act as ‘one’. At the level ofthe broader picture risk-based regulation has much to offer, the devil is in the detail of technical, legal and political...