apoptosis necrosis and other ca2 dependent forms of cell death in brain ischemia
Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
... role of TNF-α in triggering and modulating apoptosis is less clearly defined This is because, in addition to signalling through the death domain of TNFRI, TNF-α activates mainly signalling pathways ... Briefly, following induction of apoptosis, cells were fixed in 1% paraformaldehyde and incubated with Br-dUTP in the presence of TdT enzyme, which results in the incorporation of Br-dUTP into exposed ... of potential target cells is of major interest R254 In the present study we investigated the expression of the apoptosis- inducing receptor Fas in periarticular tenocytes of patients with OA and...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... BCR–ABL in inter6056 leukin-3 -dependent Baf-3 cells represses BIM and allows interleukin-3–independent survival; treatment of these cells with imatinib reverses the effects of BCR– ABL, resulting in ... drug binding) but may also arise as a result of the amplification of other oncogenes Gefitinib- or erlotinib-induced NSCLC cell death proceeds via the cell- intrinsic mitochondrial pathway, and increased ... loss of ERK1 ⁄ and ⁄ or PKB signalling and, as a consequence, promote increased expression of BIM and BIM -dependent cell death in tumour cells Here we review recent advances in understanding BIM...
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Báo cáo khoa học: Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis doc
... Protein kinase CK2: structure, regulation and role in cellular decisions of life and death Biochem J 369, 1–15 21 Meggio F & Pinna LA (2003) One-thousand -and- one substrates of protein kinase ... responses rapidly induced in cells by growth factor stimulation, and the accumulation of a 5698 variety of signaling molecules, including receptor tyrosine kinases and G-proteins, in membrane ruffles ... growth factor (EGF) and insulin-like growth factor-I are known to induce membrane ruffling, and actin cytoskeleton and signaling molecules, such as Rho family G-proteins and protein kinases, are known...
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Báo cáo khóa học: NF-jB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene ppt
... (1998) The role of tyrosine kinases and MAP kinases in LPS-induced signaling Prog Clin Biol Res 397, 119– 136 37 Yi, A.K & Krieg, A.M (1998) Rapid induction of mitogen-activated protein kinases by ... examine the contribution of NF-jB and c-Jun to LPS -dependent activation of the CMV IE enhancer/promoter Treatment of RAW 264.7 cells with LPS resulted in an approximately twofold increase in the ... protein levels We could not detect any dramatic increase in expression of NF-jB p65 or c-Jun in transfected cells using Western blotting, probably because of the transfection efficiency in RAW cells...
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Tài liệu Báo cáo " DETERMINING FLOW ENERGY AND EROSION COEFFICIENT FOR CLASSIFICATION OF POTENTIAL EROSION IN BINH DINH PROVINCE " ppt
... Determining flow energy and erosion coefficient 39 The method of erosion potential classification in Binh Dinh Province The classification of erosion potential M in Binh Dinh Province is based ... Distribution of flow energy (Y) at river basins in Binh Dinh Province (unit: %) Total in province At Lai River Basin At Kon River Basin At La Tinh River Basin At Ha Thanh River Basin
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Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes pdf
... astrocytic Ca2+ transients are accentuated in pathological conditions, suggesting the involvement of astrocytic Ca2+ transients in brain disorders, including epileptic seizures Interestingly, astrocytes ... Ca2+ oscillations, followed by the spreading of Ca2+ transients in adjacent astrocytes to form intercellular Ca2+ waves by a mechanism of chemical coupling mediated by ATP In both cases, an increase ... expressing the vesicular glutamate transporters, and release glutamate in a Ca2+ -dependent and SNARE -dependent manner [10] These findings strongly suggest that exocytotic machinery is involved in...
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Tài liệu The Banker and the Bear The Story of a Corner in Lard ppt
... again and again that it was nothing, but just as often they again began wondering what it was .And the fear of making themselves ridiculous kept them of speaking of it to John Jack's distrust of ... keeping within the fact; and then this was the strongest reason of all his mouth and something in the inflection of his voice reminded her of her mother Jack Dorlin's disgust when he heard of Dick's ... fender and smoked cigars, and there was nothing to prohibit a boy and a girl from sitting close together on the wide sofa and looking over portfolios of steel engravings from famous paintings and...
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Tài liệu Báo cáo khoa học: Insulin-dependent phosphorylation of DPP IV in liver Evidence for a role of compartmentalized c-Src ppt
... exogenously added proteinase K Regulation of DPP IV trafficking A B DPP IV levels following stimulation with insulin and bpV(phen) In order to examine changes in DPP IV levels following insulin stimulation, ... were injected with the PTP inhibitor bpV(phen) 16 h and 30 prior to insulin injection and isolation of the G ⁄ E and PM fractions No effect on DPP IV level was detected following insulin injection ... cells, a study of chimeric forms of DPP IV has shown that the luminal domain of DPP IV carries dominant apical sorting information while the short cytoplasmic tail and the transmembrane domain...
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Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
... mixing times of 80 ms and 40 ms, respectively [53,54] Analysis and modeling of sequences and structures We used Chothia’s scheme for the numbering of the aminoacid sequences of immunoglobulins and ... alanine scanning of the L-CDR3 and H-CDR3 loops of antibody mAb4E11 This scanning allowed us to identify the residues of these loops that contributed to the energetics and kinetics of the interaction ... antigen and that the effects of their mutations into Ala on the energy of interaction were indirect and conformational In VH, the same comparison suggested that the side chains of residues H-Trp96 and...
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Tài liệu Báo cáo khoa học: Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae docx
... 4.9 a This strain was grown in media lacking leucine The other strains were grown in media containing leucine Complementing abilities of LEU2, UTR1 and YEF1 for the growth defects of the pos5 mutant ... Doubling time of WT (BY4742) and pos5 mutants Means of two independent experiments are provided Arginine concentrations are specified in parentheses in mgÆL)1 In this study, 20 mgÆL)1 arginine ... and intermediates involved in NAD biosynthesis (nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, nicotinic acid and quinolinic acid) did not inhibit Yef1p (Table 2) HgCl2 inhibited...
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BONDS AND CLIMATE CHANGE THE STATE OF THE MARKET IN 2012 pdf
... prompting increasing costs, reductions in the term of loans and introducing greater refinancing Bonds and Climate Change www.climatebonds.net June 2012 this is the year the Kyoto Protocol came into ... to increase opportunities to make low-carbon fixed income investments, December 2011 “Investor interest in the links between bonds and climate change is growing” risk.3 In addition, changing ... footprints • Bonds linked to the expansion of wind and solar power account for two-thirds of the USD29bn in energy bonds • Large corporates including Sunpower, Solarworld, Goldwind, Sinovel and Suntech...
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Báo cáo khoa học: Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver pot
... uncoupling and swelling, and inhibition of respiration in state [3,4] Furthermore, it has been suggested that Cu2+ ions inhibit SDH [10] Cd2+ and Cu2+ ions induce cell death by necrosis and apoptosis ... Effect of Cd2+ and Cu2+ ions on the kinetics of the CoQ-reducing and CoQoxidizing modules Effect of Cd2+ on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B) Effect of Cu2+ ... on the kinetics of the CoQ-oxidizing module (C) and CoQ-reducing module (D) The kinetics of the CoQ-oxidizing module were obtained by titrating with a specific inhibitor of the CoQ-reducing module,...
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Báo cáo khoa học: Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein pdf
... proteins A C Vps1p and Dnm1p: two dynamin-like proteins involved in fission of peroxisomes and Woronin bodies B D Fig Ultrastructure of giant Woronin-body-like organelles and peroxisomes in BY4742 ... double-immunofluorescence staining was carried out in strain BY4742 co-expressing the artificial peroxisomal marker protein GFP-SKL and HEX1 In a few cells, GFP-SKL showed a rim-like staining around the hexagonal ... It will be interesting to see whether the absence of both dynamin-like proteins prevents the fission of Woronin bodies in filamentous fungi It is worth noting that in the vps1Ddnm1D strain, HEX1...
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Báo cáo khoa học: Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract pdf
... method of Bradford [32] using bovine serum albumin as standard Rat gastrointestinal tissues were fixed, processed routinely, and embedded in paraffin as described for ISH Localization of ADH4 was investigated ... gradually appeared in the mucussecreting epithelium as well (cf Fig 3B,C,D) In contrast, ADH4 mRNA was detected in the mucus-secreting cells, in some of the inner cell layers, and in muscularis mucosae ... analyses Detection of ADH1 mRNA in the gastric mucosa of stomach body (A) and region close to pylorus (B–D) ADH4 mRNA (E,F,I,J) and protein (G) in the cells lining gastric pits of mucosa in the stomach...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... ANT1-silencing induces glioblastoma cell death A Fig Analysis of ANT1 and ANT2 expression in nontransfected ADF cells and in ANT1- and ANT2-silenced ADF cells (A) Number of ANT1 and ANT2 transcripts in ... regulation of cell death ⁄ survival processes We analyzed the role of ANT1 and ANT2 isoforms in a human glioblastoma cell line, the ADF cells in which, we had previously characterized the effect of several ... ANT1-silencing induces glioblastoma cell death A Lena et al Because of their multitask nature, ANTs are involved in several aspects of cell metabolism, as well as in cell survival ⁄ death processes, and...
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Tiểu luận phương pháp nghiên cứu khoa học: Service personal values and customer loyalty A study of banking services in a transitio nal economy
... Cronin and Taylor, 1992; Cronin et al., 1997; Lages and Fernandes, 2005; Cheng et al., 2008; Spreng and Singh, 1983; Oliver, 1980: thỏa mãn Bowen Chen, 2001; Cooil et al., 2007; Ples hco and ... al., 2008; Martin-Consuegra et al., 2007; Henning-Thurau et al., 2002; Wong and Zhou, 2006; Story and Hes s, 2006; Reichheld, 2003; Pleshco and Baqer, 2008; Cheng et al., 2008; Mittal and Kamakura, ... mẫu Ngân hàng % ACB 19.4 Viet inBank 11.6 EAB 18.3 SacomBank 11.9 Viet comBank 21.6 Khác 17.2 T cộng 100 Vị trí % Quản lý 20.9 Nhà Kinh doanh 16 Công nhân viên 25.4 Sinh viên 18.3 Khác 19.4 Tổng...
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báo cáo sinh học:" Employment and sociodemographic characteristics: a study of increasing precarity in the health districts of Belo Horizonte, Brazil" pdf
... aims in mind: (1) to determine the contractual rights of permanent workers and non-permanent workers in the HDs; (2) to examine the profile of the permanent workers and non-permanent workers in ... Adoption Infant feeding Paternity Taking care of sick family member Accident at work Taking care of spouse or partner Military service Election candidate Personal business Professional training Entitlement ... health care sector in Brazil stands out Between 1995 and 2000, there was an increase of 113 351 posts in this sector, representing a net growth of 13.9% In 2000, 3.5% of jobs in the formal labour...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cell line Cells were incubated with increasing doses of VX-680 ... defects of mitotic spindle in VX-680 treated cells VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 cells Next, we studied if VX-680 could suppress proliferation in NB4-R2 cells in ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In the present study, phosphorylation of Akt-1 and GSK3b, the downstream of Akt-1,...
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báo cáo hóa học: " Reaching in reality and virtual reality: a comparison of movement kinematics in healthy subjects and in adults with hemiparesis" pdf
... AG, Levin MF: Recruitment and sequencing of different degrees of freedom during pointing movements involving the trunk in healthy and hemiparetic subjects Exp Brain Res 1999, 126:55-67 Cumming BG, ... ranges of joint motion and interjoint coordination) parameters Movement onsets and offsets of each phase were defined as the times at which the tangential velocity of the IRED on the index finger ... rehabilitation Interest in training in virtual environments is increasing amongst rehabilitation professionals in light of recent evidence suggesting that neuronal recovery after strokerelated brain damage...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... of oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% of the remaining of the initial death) combined with the initial loss ... Boehringer-Mannheim, Indianapolis, IN) or βactin (Sigma, St Louis, MO) antibodies for detection of the level of dopaminergic neuronal terminals, and for normalization of the loading protein The ... activity testing machine, revealed the ability of valdecoxib to maintain rearing activity closer to that of control-salinetreated mice (B) and to their baseline prior to MPTP injection (A) In agreement...
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