Nghiên cứu bào chế viên nifedipin giải phóng kéo dài theo cơ chế bơm thẩm thấu ban tieng anh

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Nghiên cứu bào chế viên nifedipin giải phóng kéo dài theo cơ chế bơm thẩm thấu ban tieng anh

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Mục lục

  • 1.1.1. Formula, nomenclature

  • 1.1.2. Physical and chemical properties

  • 1.1.3. Analytical methods

  • 1.1.4. Pharmacokinetics

  • 1.1.5. Pharmacological effects

  • 1.1.6. Indications, dosages

  • 1.1.7. Undesirable effects

  • 1.1.8. Some preparations containing nifedipine on the Vietnamese market

  • 1.1.9. Some studies on the extended-release drug delivery system containing nifedipine

  • a. Extended-release tablet dosage form

  • b. Extended-release pellet form

  • c. Sustained-release microspheres, microbeads form

  • 1.2.1. Structure and mechanism of drug release

  • 1.2.1.2. Mechanism of drug release

  • 1.2.2. Advantages and disadvantages

  • - If the coating process was not well controlled, the nonuniformity coating results in different release patterns between batches, and there was a risk of film defects led to dose dumping.

    • 1.2.3. Composition

    • 1.3.1. In vitro drug release studies

    • USP 38 monographs of NIF extended-release tablets specified 8 dissolution tests for NIF extended-release tablets.

    • 1.3.2. In vivo bioavailability studies

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