Vevođ 2100 Features v1.2 New and Improved Features ã New Features – – – – Faster frame rates Multiple focal zones Steerable Doppler Advanced cardiac strain analysis package – Color Doppler Mode – ECG gated acquisition – Large animal imaging: rabbit • Improved features – Improved Power Doppler Mode sensitivity – Faster 3D acquisition – Software workflow Vevo 770 Vevo 2100 Mechanical vs Linear Array • element • focal depth • Lower frame rates, due to the need to mechanically scan • 256 elements • Dynamic focusing throughout the entire image • Higher frame rates due to electronic switching of the elements • Simultaneous modes • Doppler Steering Vevo 770: 707B – 30 Mhz •Typical frame rate 100 fps •Max frame rate (1 mm width) 240 fps Vevo 2100: MS400 – 30 Mhz •Typical frame rate 300 fps •Frame rate 500 fps with 4.5 mm FOV •Max frame rate (2 mm width) 1000 fps Multiple & Dynamic Focal Zones Multiple/Dynamic Focal Zones: Sagittal Profile at E12 Video Loop Vevo 2100 Multiple/Dynamic Focal Zones: Midline Abdominal Landmarks Video Loop Color Doppler Mode Imaging Color Doppler Mode: Mitral Valve Inflow Vevo 2100 Video Loop Aortic Arch - Banding ~800 mm/s ~3800 mm/s Vevo 2100 Kovacs, Washington University Vevo 2100 Color Doppler: Spleen Video Loop Faster 3D Scanning • Linear array technology drastically reduces the amount of time is takes to acquire a 3D Power Doppler image • 3D B-mode Imaging ~2x faster • 3D Power Doppler Imaging ~10x faster Nonlinear Contrast Mode and VevoCQ™ Software Vevo MicroMarker® Applications Mouse subcutaneous hind limb model Image courtesy of Lazar J, SUNY Downstate Medical Center, 2010 Video Loop Vevo MicroMarker Quantification User defined regions of interest Curve fit algorithms Perfusion Quantification Selection of VevoCQ bolus perfusion model parametric outputs Whole Tumor (green) Bottom Right (yellow) Upper Area (pink) Bottom Left (turquoise) Peak Enhancement (a.u.) 29.6 8.2 41.7 8.3 Time to Peak (sec.) 3.8 3.7 3.7 2.8 Wash-in Rate (a.u.) 15.5 4.5 22.6 6.1 Parametric images Peak Enhancement Time to Peak Wash-in Rate Targeted Microbubble Ultrasound VEGFR2 Isotype Control Mouse subcutaneous hind limb model Targeted Biomarker Quantification User defined regions of interest Curve fit algorithms Targeted Biomarker Quantification VevoCQ software differential targeted enhancement parametric output Whole Tumor (Green) Left Area (Yellow) Right Area (Pink) VEGFR2 7.56 10.00 5.79 Isotype Control 1.47 2.08 1.08 Parametric images VEGFR2 Isotype Control Transducer MS220: For Larger Targets and Animals 15 MHz Transducer MS200: Rabbit Heart 3kg Rabbit Video Loop Software Improvements Study Management Image of split screen Summary • • • • • • • • • • • • Linear array probe Faster frame rate Multiple focal zones Nonlinear Contrast Steerable Doppler Advanced cardiac strain analysis package Color Doppler Mode ECG gated acquisition 3D Cardiac Imaging Improved Power Doppler Mode sensitivity Faster 3D acquisition Large rat and rabbit imaging Vevo 770 Vevo 2100 www.visualsonics.com Head Office – Canada 3080 yonge street suite 6100 box 66 toronto canada M4N 3N1 US 100 park avenue, suite 1600 new york, NY 10017 Europe Science Park 406 1098 XH AMSTERDAM The netherlands +1 416.484.5000 +1.866.416.4636 (north america) +800.0751.2020 (europe) VisualSonics, VisualSonics logo, VisualSonics dot design, Vevo, Vevo MicroMarker, VevoStrain, VevoCQ, SoniGene, RMV, EKV, MicroScan, LAZRTight, Insight through In Vivo Imaging, are registered trademarks (in some jurisdictions) or unregistered trademarks of VisualSonics Inc © 2011 VisualSonics Inc All rights reserved