Parkinsons disease for dummies

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... MPTP, an acute insult initiates an inflammatory reaction that becomes self sustaining after the initiating agent has disappeared The MPTP model of PD has been invaluable in the studying of the ... cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson’s disease...

... a formal risk factor for the more common, sporadic form of Parkinson’s disease (PD) However, how parkin becomes dysfunctional was not well understood In this study, I found that mutations in parkin ... heterozygous parkin mutations may be pathogenic Taken together, these findings contribute significantly to our understanding of the contributors to parkin dysfunction and provide important sights into ... General discussion and conclusions 131 Contributors to parkin dysfunction 132 6.1.1 Parkin dysfunction in parkin- related familial PD cases 132 6.1.2 Parkin dysfunction in parkin- related sporadic...

... JS Protective effect of hydrogen sulphide against 6- OHDAinduced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway Br J Pharmacol 2010, 161 : 467 -480 Xie L*, Tiong CX*, Bian JS Hydrogen sulfide ... protective effect of H S against cell injury induced by 6hydroxydopamine (6- OHDA), a selective dopaminergic neurotoxin often used to establish a model of PD The effect of H S on neurotoxin, 6- OHDA ... PKC isoforms in 6- OHDA-treated SH-SY5Y cells 50 2.3.4 Effect of NaHS on cell viability in 6- OHDA-treated SH-SY5Y cells in the presence and absence of inhibitors of PKC isoforms...

... Table Some Drugs for Parkinson’s Disease Page 103 Drugs for Parkinson’s Disease Related article(s) since publication Levodopa combined with carbidopa is still the most effective treatment for symptoms ... may be higher The mg/24 hour formulation is not FDA-approved for Parkinson’s disease Usual dose is 4-6 mg/day for early-stage disease and 6-8 mg/day for advanced-stage disease Should be administered ... Guidelines from The Medical Letter • Vol 11 ( Issue 135) • November 2013 Drugs for Parkinson’s Disease Table Some Drugs for Parkinson’s Disease Drug Carbidopa/Levodopa immediate-release – generic Sinemet...

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