... RB, Pahuja A, Alleva D, Acosta HM, Martinez C, Ortega A, Lopez A, Araiza-Casillas R, Zlotnik A: Gene array analysis comparison between rat collagen-induced arthritis and human rheumatoid arthritis ... The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu1, Changwan Lu2,3, Ming T Tan3 and Kamal D Moudgil1,4,* ... development of arthritis and its severity was evaluated regularly by examination of all paws for signs of arthritis, and graded on a scale from 0-4 per paw on the basis of redness, swelling and induration...