Linear and branched chitosan oligomers as delivery systems for pDNA and siRNA in vitro and in vivo

... well-defined, low Mw chitosans (chitosan oligomers) as delivery systems for nucleic acids (pDNA and siRNA) in vitro and after lung administration in vivo In addition, the concept of receptor targeting ... uptake and efficient endosomal release Besides their efficiency as pDNA delivery systems, lipid-based formulations were reported as efficient delivery...

Ngày tải lên: 23/08/2015, 17:29

... served as cold or hot beverages Homemade chicken soup has always been perceived to be healthful.28 Before the concept of nutraceuticals was introduced, chicken soup competed with wine and yogurt for ... can be formulated to produce nutraceutical drinks is unlimited Sport beverages have a special purpose and for that reason may not be thought of as Þrst-line nutraceutical bevera...

Ngày tải lên: 25/10/2013, 21:20

... nanoparticulated combinatorial drug delivery system for simultaneous antiangiogenesis and anticancer activities could improve the therapeutic outcome The nanoparticle formulations described in this ... ligands for antitumor and antiangiogenesis activity (79-81) 1.3.2 Vascular targeted nanoparticle drug delivery Nanoparticulate delivery system surface modified with in...

Ngày tải lên: 11/09/2015, 09:58

... serve as effective protein delivery systems for the repair 28 of bone tissue The merit of the work was that the PCL-based scaffolds could serve not only as a template for bone growth but also as ... fabrication The evaluation of these novel scaffolds forms the basis of this thesis It is hypothesized that PCL-TCP scaffolds would surpass the fir...

Ngày tải lên: 15/09/2015, 17:10

... development of effective in vivo delivery systems is pivotal in overcoming the challenges in achieving efficient and targeted siRNA delivery in vivo Major hurdles in siRNA delivery in vivo and various ... progress in achieving efficient and targeted siRNA delivery in vivo, particularly by overcoming multiscale hurdles using novel siRNA carr...

Ngày tải lên: 06/03/2014, 01:23

... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti -cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... doi:10.1186/1476-4598-10-3 Cite this article as: Bolhassani et al.: Improvement of different vaccine delivery systems for cancer therapy Molecular Cancer 2011 1...

Ngày tải lên: 06/03/2014, 02:21

... thinking Because of the synthesis impairment, acetylcholine is decreased in the neurons in the Alzheimer disease brain, leading to the incapability of learning, memory, and thinking Providing ... there are great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the...

Ngày tải lên: 20/06/2014, 22:20

... in a decrease in capillary flow and thus a decrease in Vc This will result in a reduction in surface area available for gas exchange, and therefore in a decrease of Dm [25] Secondly, parenchymal ... capacity of the alveolar capillary membrane as percentage of predicted (Vc%/Dm%) and the pulmonary vascular resistance (PVR) and the mean pulmonary artery...

Ngày tải lên: 12/08/2014, 14:20

... densities up to 3.5 Tb/in2 [43] 1.7 Heat- Assisted Magnetic Recording The concept of heat- assisted magnetic recording (HAMR) is similar to the concept of magneto-optical recording proposed by Katayama ... by thermal fluctuations but is prevented by an energy 11 barrier given by the product of the magneto crystalline energy and the volume of the magnetic...

Ngày tải lên: 09/09/2015, 08:17

... 70 2. 2 .2. 3.1.3 Coomassie Blue staining 71 2. 2 .2. 3.1.4 Electroblotting 71 2. 2 .2. 3.1.5 Immunoblotting 71 2. 2 .2. 3 .2 Flow cytometry 72 2 .2. 2.4 Animal work 73 2. 2 .2. 4.1 Mouse strains 73 2. 2 .2. 4 .2 Intranasal ... Bacterial strains 67 2. 2 .2. 1 .2 Culture conditions 68 2. 2 .2. 2 Bacterial transformation 69 2. 2 .2. 2.1 Preparation of electrocompetent cells 6...

Ngày tải lên: 09/09/2015, 08:18

... study was limited in its scope, the results indicate that WNV strain IS-98-ST1 is suitable as viral model for West Nile encephalitis in the Old World The Israeli strain IS-98-ST1 that caused the ... the fact that an Israeli WNV strain was introduced in New York City in 1999 [4] The murine model of WNV-associated encephalitis has been wid...

Ngày tải lên: 18/06/2014, 22:20

... the data collection phase and the start of assembly and analysis The end of this phase will be marked clearly on the snake genomics website [21], as will milestones of data analysis and release ... 100:659-674 Page of doi:10.1186/gb-2011-12-7-406 Cite this article as: Castoe TA, et al.: Sequencing the genome of the Burmese python (Python molurus bivittatus...

Ngày tải lên: 09/08/2014, 23:20

... this article as: Moens et al.: Spinal cord stimulation as a treatment for refractory neuropathic pain in tethered cord syndrome: a case report Journal of Medical Case Reports 2010 4:74 Submit your ... electrical nerve stimulation (TENS) partly diminished her pain Subsequently, a spinal cord stimulator (SCS) was surgically placed when our patient was...

Ngày tải lên: 11/08/2014, 11:23

... curves for overall in- hospital mortality of the examined scoring systems MEDS, mortality in emergency medicine sepsis score; MEW, modified early warning; REMS, rapid emergency medicine score; ROC, ... general internal medicine departments Previous studies investigating scoring systems in septic patients were largely confined to ICU settings [8-12], whereas toda...

Ngày tải lên: 14/08/2014, 08:21