microparticles as drug delivery systems for the back of the eye

... of CNT-based drug delivery systems in practical therapy comes into fruition The biosafety of SWCNT used as drug carriers Although there are exciting prospects for the application of CNTs as drug ... there are great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems ... closed (B) The schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with...

Ngày tải lên: 20/06/2014, 22:20

... The thesis is submitted for the degree of Doctor of Philosophy in the Department of Oral & Maxillofacial Surgery at the National University of Singapore under the supervision of Associate Professor ... evaluate the efficacy of the scaffolds as delivery systems for multiple growth factors, platelet-rich plasma (PRP) was used The buffers sufficed as important determinants of the release profiles ... serve as effective protein delivery systems for the repair 28 of bone tissue The merit of the work was that the PCL-based scaffolds could serve not only as a template for bone growth but also as...

Ngày tải lên: 15/09/2015, 17:10

... consequence of, selection of a sub-population of cells that are eventually capable of completing all the metastatic cascade steps (7) Typically, the process of metastasis has been viewed as a series of ... series of pre-malignant states into invasive cancers (3) 1.1.2 Metastasis of cancer Metastasis, the spread of cancer from its primary site to a distant organ, is responsible for the major cause of ... overall VIII therapeutic efficacy of the conjugated anticancer drug was, to some extent, compromised after conjugation In addition, the drug release profile of doxorubin from the matrix was in a sustained...

Ngày tải lên: 11/09/2015, 09:58

... adverse health effects for a high percentage of the population As the intake of a nutrient increases above the UL, the potential risk of adverse affects increases.35 The UL for some essential nutrients ... compounds in the diets was not reported, but the absence of these data does not diminish the value of the study In summary, the results of this study showed that the phenolic content in the blood of individuals ... nucleotides, and other cellular molecules.12 However, the acceptance of folic acid is more easily grasped by the consumer as an aid in the prevention of neural tube birth defects.13 The marketing of foods...

Ngày tải lên: 25/10/2013, 21:20

... Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ... absorption  Increase chemical and metabolic stability  Mask irritation or taste MAIN TYPES OF PRODRUGS FOR TARGETED DRUG DELIVERY (a): Classic prodrugs: prodrugs are transformed into one or...

Ngày tải lên: 18/04/2014, 15:37

... protection for pDNA together with the ease of dissociation and release of pDNA probably explain the increased efficiency of the DP 15-21 polyplexes in vivo The ease of dissociation in the presence of ... Non-viral gene delivery systems The increased risk of using viral delivery systems for gene therapy of genetic or acquired human diseases has motivated the search for, and utilisation of, safer carrier ... instead of using the transferred bacteria for pDNA delivery, they are exploited as a factory for the production of therapeutic peptides or proteins in situ [77] AGT allows the levels of the expressed...

Ngày tải lên: 23/08/2015, 17:29

... than the coercivity of the medium The medium is then left for fast cooling in the presence of the applied field, which thus results in retention of magnetic information A schematic diagram of the ... and one of the first widespread uses of magnets was as a navigational aid in the form of a compass In a bar magnet, the end of magnet pointing toward North is termed the north pole, and the end ... image showing the area illuminated by the HAMR laser The domains in the black lines have a magnetic orientation opposite to that of the other areas on the sample (b) MFM image of the same lines...

Ngày tải lên: 09/09/2015, 08:17

... vectors for their transmission; therefore, the geographical distributions of these viruses follow the distributions of their vectors [5] With the worldwide presence of the Aedes mosquito in the tropics ... [54] Vascular leakage is a hallmark of severe dengue disease in humans; development of vascular leak in AG129 therefore significantly increased the relevance of this model for the study of dengue ... (104 PFU) of virus [55] The uniqueness of this model lay in the onset of severe disease after the viraemic phase, which resembled the disease kinetic in humans Other mouse models, in contrast, exhibited...

Ngày tải lên: 09/09/2015, 08:18

... describes the application of SBA-15 in the delivery of the small molecule model drug of ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release ... tolerance of a variety of manufacturing methods Polymeric drug delivery systems under wide investigations are classified according to the mechanism controlling the release of the drug Some of the basic ... observed that the drug would be more soluble in the polymer phase as the difference in the solubility parameters of the drug and polymer becomes smaller Therefore, for the design of a specific...

Ngày tải lên: 13/09/2015, 19:46

... step-by-step approach in the analysis of the use of foams for controlled release of Paclitaxel as implants within the brain for the post-surgical treatment of glioblastoma multiforme through combining ... in the resection cavity, and the wound was closed by suturing On day 8, the animal was re-anesthetized, the wound reopened and the foam was placed on top of the tumor implant The wound was then ... vitro release profile Reproduced from J Xie et al (2006) [26] 4.2 EHDA Microparticle In Vivo Release The objectives of the In vivo release was to compare the release profile of the microparticles...

Ngày tải lên: 05/10/2015, 21:33

... 15.2 The Clinical Need for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons ... rate for the drug Therefore, it is essential that manufacturing routes achieve control of the size of the drug phases within the polymer phase and efficient dispersion of the drug phase A further ... loading of up to 20% w/w of protein in the polymer with full retention of the protein enzymatic activity The addition of PEG to the formulation eliminated the burst release of drug and drug release...

Ngày tải lên: 25/10/2013, 08:20

... designated as feasible candidates for drug delivery systems, anti-cancer agents and vaccine immunotherapy For example, DNA vaccine delivery to APCs has been facilitated by microencapsulation of plasmid ... provide the basis for the design of DNA vaccine in human clinical trial in the future Altogether, route of DNA immunization and its formulation could represent an important element in the design of ... that the technique of ultrasound can aid in the transduction of naked plasmid DNA into colon carcinoma cells Furthermore, the intra-tumoral injection of naked plasmid DNA followed by ultrasound...

Ngày tải lên: 06/03/2014, 02:21

... oxidase (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the ... into the cell White et al [60] demonstrated that CQ facilitated the delivery of Cu and Zn across the plasma membrane, as determined by inductively coupled plasma mass spectrometry Once inside the ... because of an imbalance in the activity of tau kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently...

Ngày tải lên: 07/03/2014, 10:20

... To measure the phraseness of a candidate phrase we use a technique based on the χ2 independence test We measure the independence of the events of seeing the components of the phrase in the text ... which measures the maximum centrality score the phrase achieves across the entire book This can be thought of as a measure of the importance of the phrase in a smaller coherent segment of the document ... means the elimination of instances from the majority class (in our case negative examples), while oversampling focuses on increasing the number of instances of the minority class Aside from the...

Ngày tải lên: 08/03/2014, 01:20

... sequencing of whole plastids and genomes of a number of photosynthetic organisms Recently, De Las Rivas et al [15] summarized the nature and composition of the extrinsic proteins of different ... with the result of Shibata et al [21] The presence of PsbV in C paradoxa is consistent with the presence of the psbV gene in the complete sequences of the cyanelle genome [24], in which the psbU ... this gene in the cyanelle genome suggested that this gene has been transferred to the nuclear genome in this organism, as in the case of red algae On the other hand, the failure of cross-reaction...

Ngày tải lên: 23/03/2014, 15:21

... clearance, and the constraints imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY SYSTEMS The principal ... or sites has led to the development of alternative drug delivery systems, which attempt to address the requirements of rate and extent of drug release, and thereby absorption Delivery systems include ... advanced drug delivery systems Chemical Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES...

Ngày tải lên: 28/03/2014, 10:20

... of its business: The bank’s operating income for months of 2012 before allowances for credit losses amounted to EUR 69.3 million During months of 2012, the amount of deposits with the bank has ... and customers for their loyalty and to all officers of ABLV Group for their important contribution in achievement of the company’s targets! ABLV Bank, AS public quarterly report for the period ended ... present, the legal address of the bank is Elizabetes Street 23, Riga The bank operates in accordance with the legislation of the Republic of Latvia and the license issued by the Bank of Latvia...

Ngày tải lên: 29/03/2014, 03:20

... analysis from small to large scale circuits For example, the impulse response of the circuit of Figure 2(a) is the convolution of the impulse responses of each of the elementary cells: h(t) = (h1 ⊗ h2 ... linear circuit is the convolution of the individual impulse responses (a), the shaping curve of the concatenation of two shapers is the convolution of the individual shaping curves (b) There are thus ... (t) of a linear circuit to the sum of two inputs x + n is the sum of the individual responses (a), but the response ytot (t) of a greedy shaper to the aggregate of two input flows x + n is not the...

Ngày tải lên: 31/03/2014, 22:20

... anticancer drugs They demonstrated that the drug release from these systems can be controlled by controlling the particle size, as they found the larger the NPs size, the lower was the drug release The ... of the factors for the formulation of the lipid NP are: the drug payload depends on the oil content, the evolution of the hydrophilic–lipophilic balance of solutol HS15 is the driving force of ... armamentarium of systems for the targeting of drugs Parallel to these developments has been, since the early 1970s, the exploitation of liposomes as a delivery system for drugs and vaccines These superstructures,...

Ngày tải lên: 04/06/2014, 14:47