micro and nanoparticulate polymeric delivery systems for nucleic acid based medicine

... standard and one of the most efficient non-viral systems for nucleic acid delivery Therefore, PEI has been selected as a reference delivery system in this thesis, and the properties of PEI -based ... non-viral delivery systems for nucleic acids include PEI, polyamidoamine (PAMAM) dendrimers, poly-L-lysine (PLL) and chitosan (Figure 6) Figure Cationic polymers most commonly used for nucleic acid delivery ... Gene delivery systems 14 Viral gene delivery systems .14 Non-viral gene delivery systems 14 Naked (unformulated) nucleic acids .15 Barriers to non-viral gene delivery...

Ngày tải lên: 23/08/2015, 17:29

... designed and fabricated several multifunctional and/ or combinatorial nanoparticulated delivery systems aiming to disrupt tumor endothelial cells and induce apoptosis in tumor cells simultaneously for ... ligands for antitumor and antiangiogenesis activity (79-81) 1.3.2 Vascular targeted nanoparticle drug delivery Nanoparticulate delivery system surface modified with integrin targeting ligand ... identified for both breast and prostate cancer, for example In contrast, fewer numbers of skin metastases than expected based on blood-flow patterns were found for osteosarcomas, stomach and testicular...

Ngày tải lên: 11/09/2015, 09:58

... chemical and physical properties and sources Maltitol (2) Palantinose and tea polyphenol (1) Maltitol and palantinose and tea polyphenol (1) Maltitol and palantinose and erythritol and tea polyphenol ... Phenolic acids C6–C1 Salicylic acid D Acetophenones C6–C1 3-Acetyl-6-methoxybenzaldehyde E Phenylacetic acids C6–C2 p-Hydroxyphenylacetic acid F Hydroxycinnamic acids C6–C3 Caffeic acid Chlorogenic acid ... Dietary Reference Intakes (DRI) for dietary Þber at 38 g/day for men and 25 g/day for women 110 Median intakes of dietary Þber in the U.S for men and women are 17 and 13 g/day, respectively.110...

Ngày tải lên: 25/10/2013, 21:20

... Strategies for cancer vaccine development Journal of Biomedicine and Biotechnology 2010, 1-13 58 Masotti A, Ortaggi G: Chitosan micro- and nanospheres: fabrication and applications for drug and DNA delivery ... designated as feasible candidates for drug delivery systems, anti-cancer agents and vaccine immunotherapy For example, DNA vaccine delivery to APCs has been facilitated by microencapsulation of ... Electroporation Laser II Viral and non-viral delivery systems (Non-physical delivery methods) including: Biological gene delivery systems (viral vectors) Non-biological gene delivery systems (non-viral vectors)...

Ngày tải lên: 06/03/2014, 02:21

... event -based view to an external state -based view But the “event-driven” ap- plications that use select() to obtain notifications ultimately follow the event -based view, and thus spend effort tranforming ... of events, and dispatches event handlers for each event At line 16, there is a special case for the socket(s) on which the application is listening for new connections, which is handled differently ... procedure named WaitForMultipleObjects(), declared as: DWORD WaitForMultipleObjects( DWORD cObjects, // number of handles in handle array CONST HANDLE * lphObjects, // address of object-handle array...

Ngày tải lên: 07/03/2014, 17:20

... nanocrystals, and lipid -based nanoparticulate drug -delivery systems, respectively Chapters to 10 discuss the engineering aspects and different techniques used for nanoparticulate drug -delivery systems, ... different properties and advantages when formulated as drug -delivery systems A brief description of each of the polymeric systems follows Hydrogel -Based Nanoparticulate Drug -Delivery Systems A progressively ... nasal delivery system for human growth hormone, a pulmonary delivery system for vasoactive intestinal peptide, a noninvasive delivery system for the KLH antigen, and nasal delivery systems for...

Ngày tải lên: 04/06/2014, 14:47

... them suitable candidates for a nanoparticle -based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum ... with folic acid (FA), the targeting effects may be further improved Such nanocarrier -based drug delivery systems for doxorubicin could be more selective and effective than the free drug and have ... the debunching and solubilization of CNTs using nucleic acids and amphiphilic peptides based on the π-π stacking interactions between the CNT surface and aromatic bases/amino acids in the structural...

Ngày tải lên: 20/06/2014, 22:20

... Agroforestry Systems Outputs and Performance indicators Outputs ♦ The enhancement of training/extension and research services on agroforestry systems for sustainable livestock production for ... significant cash income for concentrate feeds are most July 2002 CARD Vietnam – Agroforestry Systems Implementation Performance 3.1 Project Components and Outputs Compone Performance Perform' Component ... centre of the National Institute for Animal Husbandry) and Dr Ha Huy Thinh of the Research Centre for Forest Tree Improvement (RCFTI) (a research centre of the Forest Science Institute of Vietnam)...

Ngày tải lên: 22/06/2014, 13:20

... B, and Faces94 were 64 × 64, 32 × 32, and 45 × 50 pixels, respectively For these face image sets, the number of classes and number of samples per subject were 40 and 10, 38 and 60, and 150 and ... between 0.0 and 1.3, the proposed pairwise system outperforms the multiclass system For instance, for alpha = 0.0, a gain in the performance is 2.0% on the ORL and 4.0% on the Yale datasets For alpha ... given between 50 and 200 Table shows the performances of the pairwise and multiclass systems for these data From this table we can see that the proposed pairwise system outperforms the multiclass...

Ngày tải lên: 22/06/2014, 19:20

... to the academic and research staff at the Department of Electrical and Computer Engineering, Spin and Energy Lab (SEL) and Centre for Optoelectronics (COE) ii Abstract The demand for magnetic storage ... especially Mr and Mrs Ehsan Younis, Muhammad Hafeez, Fraz Ahmed, Yasir Cheema and Wakil Shehzad for their guidance, help and encouragement A special thanks to my i best friend Ms Nurjiha, for always ... Singapore for their appreciated help and friendship Special thanks go to Dr Deng Jun and Mr Siew Shawn Yohanes for their help in wafer dicing, thesis editing, FIB, metal deposition and programming...

Ngày tải lên: 09/09/2015, 08:17

... VACCINE CANDIDATE 4.2 146 BORDETELLA PERTUSSIS AS A LIVE VECTOR FOR THE PRODUCTION AND MUCOSAL DELIVERY OF DENV2 EDIII 4.3 147 LACTOCOCCUS LACTIS AS A LIVE VECTOR FOR THE PRODUCTION AND MUCOSAL DELIVERY ... most patient and encouraging supervisor I could ask for and, once again, I offer my sincere appreciation for all she has taught me To my lab mates, past and present, I thank you all for making ... (receptor for CCL28, which is secreted by epithelial cells of the intestines, salivary glands, tonsils, respiratory tract and lactating mammary glands) and α4β7-integrin (receptor for MADCAM1,...

Ngày tải lên: 09/09/2015, 08:18

... mother, Madam Pushpa Devi, for all her sacrifices, for always being there and for pushing her to strive for excellence She thanks her bosom friends for being so kind and understanding during this stressful ... PCL -based honeycomb scaffolds as drug delivery systems for rhBMP-2 Biomaterials 2005; 26(17): 3739-3748 B Rai, S.H Teoh and K.H Ho An in vitro evaluation of PCL-TCP composites as delivery systems ... scaffolds as delivery systems for a single growth factor 166 9.1.4 PCL-TCP scaffolds as delivery systems for multiple growth factors 167 9.1.5 Rat femoral defect model 168 9.1.6 Dog mandible defect...

Ngày tải lên: 15/09/2015, 17:10

... domains G and II and domains III, IV and V In the S aureus EF-G structure, this loop has a bent conformation, and packs against domain III and interacts with the linker between domains III and IV ... Structure superposition was performed with o [47] Acknowledgements We thank the SLS and ESRF for beam time and support during data collection, and K Backbro and C S ¨ Koh for comments on the manuscript ... hydrolysis and translocation [25] FA binds to a pocket between domains I, II and III of EF-G, and seems to lock EF-G in a conformation intermediate between the GTP-bound and GDP-bound forms [22]...

Ngày tải lên: 06/03/2014, 22:21

... checking for the insertion of transformed genes into host chromosomes, checking for gene copy number and so on 2.2 RNA Preparation and Blotting Chapters and describe the preparation of plant and animal ... research setting and a small number of samples These systems have as their goal easy and high throughput screening for the presence of particular nucleic acid sequences Chapters 31 and 32 deal with ... uniformly brittle After removing pieces of stem and leaf midribs (see Note 5), mill the samples using either a sample mill or pestle and mortar with grinding sand Use a fresh pestle and mortar for...

Ngày tải lên: 11/04/2014, 10:14

... performance There is a rich literature [2, 36] on fusing multiple modals for identity verification, for example, combining voice and fingerprints, voice and face biometrics [37], and visible and ... staff and students of our institute, with 12 pairs of appearance and disparity images for each subject Two pairs per person are randomly selected for training while the remaining ten pairs are for ... images, and ml and mr are the number of the % discriminant components of left and right B2DLDA transform Output: Wl , Wr , Bl1 , Bl2 , , Bln , Br1 , Br2 , , Brn % Wl and Wr are the left and...

Ngày tải lên: 22/06/2014, 19:20

... affordable hardware platforms and a novel and customizable universal software platform The hardware platforms include commercial force-reflecting joysticks and wheels with the custom-made platforms ... hypotheses and Mean and standard deviation values are calculated and presented for control (n = 8), high function (n = 5), and low function (n = 4) groups for the joysticks and high function (n = 4) and ... on Target (PTT) for continuous tracking for CJS and TheraDrive wheel Percentage Time on Target (PTT) for continuous tracking for CJS and TheraDrive wheel This figure shows PTT for continuous tracking...

Ngày tải lên: 11/08/2014, 14:20

... true in medicine is seldom straightforward Competing interests ALG declares that they have no competing interests KGS is a consultant for and received research grants from TAP, Savient, and Merck ... older postmenopausal women followed for 21 years [6] In contrast, Simon and colleagues did not find an association between serum urate levels and the risk for coronary heart disease events There ... augment the risk for cardiovascular disease per se In summary, the article by Hak and Choi contributes a valuable piece of information to the literature about the Page of (page number not for citation...

Ngày tải lên: 09/08/2014, 13:22

... Reaction–Diffusion Systems for Micro- and Nanotechnology Bartosz A Grzybowski Northwestern University, Evanston, USA Chemistry in Motion Chemistry in Motion: Reaction–Diffusion Systems for Micro- and Nanotechnology ... at micro- and nanoscales and to fabricate a variety of small-scale structures: microlenes, complex micro uidic architectures, optical elements, chemical sensors and amplifiers, unusual micro- and ... (1997) Handbook of Microlithography, Micromachining, and Microfabrication, IET, London 55 Thompson, L.F and Kerwin, R.E (1976) Polymer resist systems for photolithography and electron lithography...

Ngày tải lên: 04/06/2014, 15:05

... Kizek R: Easy to use and rapid isolation and detection of a viral nucleic acid by using paramagnetic microparticles and carbon nanotubes -based screen-printed electrodes Microfluid Nanofluid 2010, ... considered as a suitable tool for detection of nucleic acids We show the successful application of modern nano-technologies not only for detecting of nucleic acids but also for distinguishing of all ... of (D) single strand oligonucleotide influenza (13 μg/mL), and (E) double strand genomic DNA (15 μg/mL) In insets: signals of all nucleic acid bases after baseline correction and smoothing of...

Ngày tải lên: 21/06/2014, 03:20

... using DNA entrapped into polymeric particles Biodegradable poly (lactic-co-glycolic acid) microspheres (PLGA) represent an attractive candidate for vaccine delivery [19] Therefore, as an alternative ... have been employed for generation and evaluation of new TB vaccines Recombinant BCG strains, DNA -based vaccines, live attenuated M tuberculosis vaccines and subunit vaccines formulated with novel ... also evaluated both in mice and guinea pigs the use of a new concept in vaccine formulation based on a mixture of two different PLGA microspheres, presenting faster and slower release of, respectively,...

Ngày tải lên: 14/08/2014, 19:22