... 30821065 and 30870559 from the China National Nature SciencesFoundation, 2006CB910703 from the Ministry of Sciences and Technology of China, and 07dz05907from the Committee of Sciences and Technology ... adipocytes, the translo-cation of Bax from the cytoplasm into the mitochon-dria, cytochrome c release and cleavage of caspase-3were all observed (Fig. 4B–D).To confirm the involvement of Bcl-2 and ... apoptosis, the components of the PI3K–Akt-1 signaling cascadewere analyzed. As shown in Fig. 3A,B, treatment of 3T3-L1 adipocytes with troglitazone reduced the levels of Akt-1 protein and inhibited...