- D~n xuat benzamid: sulpirid, remoxiprid.
5. cAc THUOC KHAc
Dftn xu8:t benzisoxazol: risperidol.
Thu6c d6i khang 5HT2 d vo nao nen co tac dung dieu trj cac trieu chung am tinh cua tam than phan Iiet. Ngoai ra, thuoc cling co tac dung d6i khang tren receptor D2 nen con co hieu qua digu trj trieu chung duong tinh cua tam than phan liet (tac dung tren 5HT2manh hon tren D2khoang 20 l~n).
Tac dung khong mong muon co th~ g~p Ia mat ngu, ngu ga, chong mat, met moi, budn non ...
Thuoc it gay r6i loan ngoai thap hon cac thuoc kinh di~n tuy nhien vftn g~p m9t so'trieu chung nhu run co, cham chap, cirng dd...
Lieu dung: khoi dau: u6ng 2mg/ 24h, nhung ngay sau tang d~n len den ligu 6mg/ 24h. Khong nen dung qua Bmg/ 24h.
D~n xu8:t thioxanthen
Dftn xuat thioxanthen co cau truc tudng t\i phenothiazin, chi thay nitrogen b&ng carbon d nhan trung tam. Cac thu6c trong nhom g6m co thiothixen, cloprothixen, flupenthixol.
Thu6c co tac dl._lllgan th~n kinhva ch6ng non tudng t\i clorpromazin, nhllng m~nh hdn (thiothixen co tac dl._lllgm~nh hdn clorpromazin khoang 20 l~n).
Chu yeu digu tri r6i lo~n tam th~n, b~nh tam th~n phan li~t, hoang tlldng, r6i lo~n cll xi':td nglldi nghi~n ru<;lu.
Tac dl._lngkhong mong mu6n tlldng t\i clorpromazin: an th~n, h~ huyet ap va khang muscarinic. Tuy nhien, thu5c lam tang trlldng I\iCcd va gay r6i lo~n ngo~i thap nhigu hdn.
Ligu dung: Cloprothixen: 15- 50mgx 31~n/ 24h. Flupenthixol: 20 -BOmg/ 24h.
Clozapin
Dll<;lcdung dMy tit nam 1990. Tac dl._lngch6ng r6i lol',tntam th~n tlldng tt;l clorpromazin, co tac dl._lngan th~n m~nh, huy muscarinic, nhung khong co tac dl._lngch6ng non va khong anh hUdng t8i bai tiet prolactin. Thu6c chu yeu dung digu tri r6i lo~n tam th~n hllng cam d cac b~nh nhan khong dung dll<;lCcac lo~i thu5c truygn th6ng. Thu6citgay r6i lo~n ngo~i thap nhllng d~ gay d9ng kinh va uc che tuy xUdngm~nh lam giam b~ch c~u h~t.
Pimozid (Orap)
La d~n xuat diphenylbutylpiperazin, co d~e tinh tuong tu haloperidol. Thudc chu yeu dung di~u tri r5i loan tam than van d9ng, phat ngon, may co va r5i loan tam than th~ thanh xuan khi benh nhan khong dung nap vdi cac thuoc khac,
Molindon
La d~n xuat dihydroindolon co hieu luc manh gap 10 Mn clorpromazin.
Loxapin
La d~ xuat cua dibenzoxapin,co d~e di~m tac dung tirong tu clorpromazin nhung hieu hrc gap khoang 10 l:in, dung dliqcca.duong uong va tiem.
A' A' ~?