transcription factors in neuronal diseases
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... failure in post-transcriptional processing of the protein [41] Additionally, it is evident that AP-2 transcription factors can indirectly modulate genes by functional interactions with other transcription ... AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous ... maintaining cells in an early differentiated phenotype For AP-2b, expression in murine limbs has also been demonstrated AP-2b is expressed in the zone of polarizing activity (ZPA), the signaling...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... E-box binding transcription factors No canonical TATA box but a CCAAT box was found in the mouse integrin a3 subunit flanking sequence The integrin a subunit genes so far characterized contain no ... MyoD/E-box binding factors The introduction of mutation into one of the putative Etsbinding sequences suppressed the promoter activity In addition, the specific binding of a nuclear protein to the ... a3b1 integrin plays essential roles in multiple processes during embryogenesis The promoter should thus contain elements directing the expression of this integrin in the kidney, lung, and skin...
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Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... each time using 300 lL of protein-binding buffer (see above) Potentially DNA-bound proteins were subsequently eluted step-by-step using 200 lL of binding buffer containing increasing amounts ... corresponding amino acid in the first NrpR domain (S168A) retained a normal regulation [22] If the second NrpR domain of M maripaludis NrpR indeed contacts the general transcription factors, this may indicate ... of NrpRII in M mazei K Weidenbach et al 2-Oxoglutarate directly affects NrpRI binding to the operator and NrpRII binding to the general transcription factors Increasing amounts of the intracellular...
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Báo cáo y học: "Nuclear transcription factors in mammalian mitochondria" pdf
... responsive protein kinase A (PKA) or by other kinases, including mitogen-activated protein kinases (MAPKs) and Ca2+/calmodulin-dependent kinases (CaMKs) [35] A self-contained CREB pathway exists in mitochondria, ... element binding family of transcription factors: activating transcription factor proteins and homeostasis Gene 2001, 273:1-11 34 Montminy MR, Bilezikjian LM: Binding of a nuclear protein to the ... situated in a single region called the D-loop, which contains regulatory sequences that control transcription from all three promoters, including motifs for DNAbinding proteins such as Tfam The inner...
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báo cáo khoa học: " Roles of arabidopsis WRKY18, WRKY40 and WRKY60 transcription factors in plant responses to abscisic acid and abiotic stress" doc
... temperature in ABA-independent manner and exhibits continuous induction during dehydration and freezing treatment [21] In tobacco, a WRKY transcription factor is specifically induced during a combination ... sensitivity as indicated by significantly increase in inhibition of germination in the overexpression line relative to that of wild type (Figure 1C) Increased inhibition of germination in the WRKY60overexpressing ... three WRKY proteins may form a range of protein complexes with distinct DNA-binding and transcription- activating or -repressing activities The complex pattern of DNA binding and transcription regulatory...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways, however, have ... dehydrogenase Hexokinase Hexokinase Insulin-like growth factor (IGF)-2 IGF-binding protein (IGFBP)-1 IGFBP-3 Lactate dehydrogenase a Phosphoglycerate kinase Pyruvate kinase m p21 Transforming growth...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of cateκ cholamines in nuclear factor-κB regulation and cytokine expression J Clin Invest 1997, 99:1516-1524 Moine ... binding protein beta, Sp-1, AP-1 and CREB are present in the promoter regions of numerous cytokine genes, including those whose expression is increased after blood loss To investigate early transcriptional ... lungs and to increased pulmonary proinflammatory cytokine expression [7] However, the initial events induced by hyperoxia, thereby leading to acute inflammatory lung injury, remain incompletely...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... NADP, nicotinamide dinucleotide oxidized; NADPH, nicotinamide dinucleotide reduced; PKC, protein kinase C; ROS, reactive oxygen species; SAPK, stress-activated protein kinase DNA binding In hypoxia, ... element binding protein; CBP, CREB-binding protein; DAG, diacyl glycerol; ECF, extracellular fluid; ICF, intracellular fluid; IP3, inositol triphosphate; MAPK, mitogen-activated protein kinase; ... therefore be a promising therapy to reduce injury and to improve lung function play a central role in initiating the innate immune system and in activating NF-κB Anti-inflammatory cytokines have the...
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Báo cáo y học: "Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation" docx
... color indicates CK19 positive staining Arrows indicate bile duct staining Arrowheads indicate hepatocytic staining PV, portal vein; BD, bile duct Scale bar = 100 μm injuries towards self renewal ... Transforming growth factor beta (TGFb1) induction in the periductular region with no change in HNF6 staining Compared to controls (Figure 6A), TGFb1 induction was observed in the region surrounding ... Brown staining indicates PCNA positive cells Thin arrow indicates regenerating biliary ductules Arrowhead points to the hepatocyte proliferation Scale bar = 100 μm panel of ductules in which...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four transcription ... NM_003528 h IGFBP2 Insulin-like growth factor binding protein (36 kDa) NM_000597 hmr (hr) LGALS3BP Lectin, galactoside-binding, soluble, binding protein NM_005567 hmr MATN2 Matrilin NM_002380 h (hmr) ... major transcription factors associated with NF-κB were ETSF (human and murine ETS1 factors; 8/14) and ZBPF (zinc binding protein factors; 8/14) In most cases the locations of NF-κB binding sites...
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Báo cáo y học: " Regulatory module network of basic/helix-loop-helix transcription factors in mouse brai" doc
... developing brain, cross-repressive interactions between Otx2 and Gbx2 define the midbrain-hindbrain boundary [51] and interactions between the homeodomain TFs Pax6 and Pax2 help to delineate ... Multalin [http://prodes.toulouse.inra.fr/multalin/multalin.html] Zhang B, Schmoyer D, Kirov S, Snoddy J: GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using ... Benjaminni correction) with respect to GO categories Literature data mining Literature data mining was performed with the web-based tool LitMiner [68] LitMiner is a literature data mining tool...
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Báo cáo y học: "Defining and targeting transcription factors in cancer" potx
... and its regulator Mdm2 This inhibitor binds selectively to the pocket of Mdm2, resulting in increased p53 levels Nutlin was an effective inhibitor in cell lines and in mice with various types ... used for genome-wide mapping using ChIP-chip By correlating the binding profiles of all NRs, they found profile similarities and common binding sites between ER and retinoic acid receptor α; they ... are driving factors and which ones are passenger events One of the key themes of the meeting was the ability to target transcription factors using drugs Traditionally, transcription factors were...
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Analysis of transcription factors in living human cells with the help of split ubiquitin system
... is the binding site for the TATA-binding protein (TBP) In some genes, the transcription initiation site consists of the initiator element (Inr) defined as an element encompassing the transcription ... Protein-protein interactions control cellular organization and dynamics in diverse biological processes including transcription Studying transcriptional initiation and the interplay between the transcription ... imprinted proteins as well as using modification specific antibodies to isolate differentially modified proteins 49 1.3.2 Capturing Protein-Protein-Interactions inside Living Human Cells: In vivo...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... domains, including an N-terminal STAT protein interaction domain, which strengthens interactions between STAT dimers on adjacent DNA-binding sites, a coiled-coil STAT protein all-alpha domain, ... STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3 In addition, for stat6 and...
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Báo cáo khoa học: Structure of FocB – a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli pdf
... N-terminal DNA-binding domain and a C-terminal oligomerization domain The DNA-binding headpieces of the N-terminal domains contain conventional major groove-binding HTH motifs, but symmetric hinge ... is a minor groove-binding protein In general, minor groove-binding proteins show various degrees of sequence specificity when binding to DNA The lack of unique chemical features present within the ... binding to DNA in the absence or presence of the DNA-binding compounds distamycin (minor groove-binding) and methyl green (major groove-binding), respectively A 401 bp DNA fragment containing...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually specific to ERM, and the C-terminal domain that is present in ... flanking the major transcription initiation site (+1) in SK-N-SH cells included in the PS1CAT reporter fusion vector are shown The binding sites for known transcription factors Sp1 and Ets are indicated ... complexes (B) The binding of in vitro translated ERM is eliminated by mutations in Ets motifs The binding of in vitro translated ERM over the PS1 promoter was assayed by EMSAs including the 32P-labeled...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
... modular protein consisting of a helix–turn– helix class of DNA-binding domain (DBD), a leucine zipper domain, required for trimerization, and a C-terminal transcription activation domain [3] Both ... cerulenin and 1,10-phenanthroline among others, suggesting a role in the response to drug stress Indeed, several target genes encoding a set of proteins involved in the stabilization and folding ... profiles involved in arsenic response has revealed the array of genes whose transcription is enriched, including those involved in methionine metabolism and sulfur assimilation, protein degradation...
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Báo cáo y học: "What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases" doc
... milk proteins (casein and lactalbumin) can reduce serum uric acid levels in healthy individuals Genetic risk factors Advances in the genetic factors behind gout have included a variation in the ... the high incidence in females An interesting observation was the increased incidence of Klinefelter’s syndrome (47, XXY) in male patients with SLE, in whom the frequency was substantially increased ... disintegrin and metalloproteinase domain 12; ARTS1, type tumor necrosis factor receptor shedding aminopeptidase regulator; BLK, B lymphoid tyrosine kinase; CARD15, caspase recruitment domain...
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Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors" potx
... START domains are also found in various multidomain proteins implicated in signal transduction [2], suggesting a regulatory role for START-domain proteins involving lipid/sterol binding To investigate ... amino-terminal HD DNA-binding domain preceding START, a putative lipid/sterol-binding domain (b) Nuclear receptors, which are found only in animal genomes, comprise a zinc finger DNA-binding domain of the ... proteins are unique to plants, the presence of the lipid/sterolbinding domain in a transcription factor has a parallel in the animal kingdom (Figure 5) In animals, steroid-binding transcription factors...
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báo cáo khoa học: " WRKY Transcription Factors Involved in Activation of SA Biosynthesis Genes" doc
... mutations as indicated in panel B Plus signs above the lanes indicate binding mixtures containing 0.5 μg recombinant GST/WRKY28 Minus signs above the lanes indicate binding mixtures without recombinant ... WRKY28 binding sites indicated against a grey background A schematic representation of the fragments tested in EMSAs for binding WRKY28 is given in Figure 5B Figure 5C shows the consensus binding ... contains the two WRKY28 binding sites at -445 and -460 as determined by EMSA (Figure 4A) A similar result was obtained with a primer pair covering a smaller region containing the two binding sites...
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