time domain indices of heart rate variability
Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... model of parkinsonism Proceedings of the National Academy of Sciences, of the United States of America, 102, 2174 2179 1: THE ETIOPATHOGENESIS OF PARKINSON’S DISEASE: BASIC MECHANISMS OF NEURODEGENERATION ... vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson’s disease Proceedings of the National Academy of Sciences, of the United States of America, 100 (5), 2884 ... crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily Proceedings of the National Academy of Sciences, of the United States of America, 101 (6),...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
... Collateralization of Striatofugal Neurons and Co-localization of Dopamine Receptors One of the important series of data that challenged the concept of segregated direct and indirect striatofugal pathways ... excitation of GPi and SNr neurons, and to inhibition of thalamocortical cells, and reduced excitation of cortex, clinically manifest in the development of the aforementioned cardinal motor signs of Parkinson’s ... development of dyskinesias after transient inactivation of small areas of the pallidum with the GABAergic agonist muscimol (178), over a wide range of injected concentrations and volumes of the drug...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... Merritt professor of neurology at Columbia University before moving downtown, as he used to say, to Mount Sinai School of Medicine, where he become professor of neurology and chairman of the department ... affected areas of frontal cortex Conclusion Earlier models of the pathophysiology of Parkinson’s disease that emphasized the importance of changes in discharge rates in the basal ganglia of parkinsonian ... significance of neuromelanin in the human brain This symposium was dedicated to Prof Youdim on the occasion of his 65th birthday These contributions are published separately in a Special Issue of the...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... at the University of Breslau Alzheimer died at the age of 51 in 1915 as a result of cardiac failure following endocarditis, an infection of the heart 19 Signs and Symptoms of Dementia My wife’s ... after onetime use or as a result of long-term use) Seizures can cause memory loss that lasts for a limited amount of time, and an infection of the brain called encephalitis can cause symptoms of amnesia ... well as the loss of nerve cells in Huntington’s chorea He worked at the universities of Heidelberg and Munich In 1912, he was appointed professor of psychiatry and director of the Psychiatric...
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PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx
... Division of Movement Disorders; Associate Professor of Neurology, University of Southern California School of Medicine, Los Angeles, California PETER A LEWITT, M.D • Professor, Departments of Neurology, ... Associate Professor, Department of Neurology, Ohio State University, Columbus, Ohio HOWARD HURTIG, M.D • Chair, Department of Neurology, Pennsylvania Hospital; Professor of Neurology, University of Pennsylvania ... hypercontractile state of dystonia may be thought of as a kind of spasm Certain specific types of spasm of peripheral origin require further definition to avoid confusion of terms • Cramps are...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
... from nondemented persons and thus inaugurate evaluation of the former What constitutes of ce testing” is often determined by the realities of practice type, time constraints and reimbursement Many ... Benson, 1992) Clinical neuropsychology of DAT Following is a discussion of clinically pertinent neuropsychological features of DAT Expanded analyses of domain- specific (frontal-executive, visuospatial, ... pharmacological treatment of MCI has any efficacy (Doody et al., 2009) Discrepancies in conversion rates, that is, the heterogeneity of prognosis, are reflective of the heterogeneity of MCI (Albert, 2008;...
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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf
... long and illustrious history of the depiction of disorders of movement and posture through the use of drawings and still photographs, as exemplified by the work of Charcot and his pupils at L’Hôpital ... also like to express a debt of gratitude to Dr M Savoiardo who, not for the first time, has come to my rescue by providing state -of- the-art imaging material of many of the conditions discussed ... discussion of the clinical characteristics of Parkinson's disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson's...
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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot
... discussion of the clinical characteristics of Parkinson’s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson’s ... Neuropathology Typically, there is loss of at least 50% of the melanin-containing nerve cells of the substantia nigra, the changes being concentrated in the central part of the zona compacta (Figure 3) ... range of motion of any affected joint A characteristic judder (cogwheeling) occurs at a frequency similar to that of the postural tremor seen in Parkinson’s disease rather than at the rate of the...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... significantly higher stride variability The coefficient of variation (CV), a measure of stride-to-stride variability, was highest in the forelimbs of 3NP-treated mice iability of the hind limbs was ... stride length variability nor stance width variability of the hind limbs was affected after the 2nd administration of 3NP (cumulative dose of 50 mg/kg) After the 3rd administration of 3NP (cumulative ... stride length variability Subsequent gait disturbances included increased gait variability of the forelimbs and eventual failure of hind limb stepping Our findings of different effects of 3NP on...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 5 pot
... is hyperextension of the left big toe Figure 18 Dystonic posturing of the right thumb and little finger (on the left) secondary to dopa therapy ©2004 CRC Press LLC Figure 19 CT of a patient with ... above the ventricular roof with relative preservation of subcortical white matter (U fibers; black arrow) Figure 22 Histology showing parietal white matter at the bottom of the cortex, a relatively ... (same patient as in Figure 25) showing numerous small lacunes in the heads of both caudate nuclei and in the anterior part of the putamen ©2004 CRC Press LLC Figure 27 Histological sections from...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 6 ppt
... Histology of striatonigral degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the ... depletion of Purkinje cells (only two can be seen; black arrows) The remainder of the Purkinje cell layer (seen between the white arrows) consists only of small astrocytic cells Atrophy of the central ... selective reversible antagonist of D2 receptors) Figure 33 Coronal section of brain from a patient with striatonigral degeneration showing symmetrical atrophy and discoloration of the putamen ©2004 CRC...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 7 pot
... Mechanisms of actions of various botulinum toxins (BTX) Ach, acetylcholine ©2004 CRC Press LLC Figure 57 Dystonic posturing of the hand consequent to perinatal hypoxia Figure 58 Dystonic posturing of ... views of dystonic posturing of the left hand of a patient with corticobasal degeneration In particular, note the ulnar deviation at the wrist and the abducted posture of the little finger ©2004 ... posturing of the foot consequent to perinatal hypoxia There is inversion of the foot and relative dorsiflexion of the big toe of the patient’s left foot compared with the right ©2004 CRC Press LLC...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 8 ppt
... rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus (white arrow; Luxol fast blue) Figure 63 Histology of ... trinucleotide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 68 Coronal section of brain in Huntington's disease shows symmetrical atrophy and brown discoloration (arrowed) of the caudate and ... caudate and putamen together with dilatation of the lateral ventricles Figure 69 Histological section of brain in Huntington's disease shows atrophy with loss of neurons and astrocytic gliosis (immunocytochemistry...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... damage of DNA; (2) oxidations of unsaturated fatty acids in lipids; (3) oxidations of amino acids in proteins; and (4) inactivation of specific enzymes through oxidation of catalytic cofactors ... beat or loss of rhythm is a common heart arrhythmia that can occur with or without heart failure Atrial fibrillation, often describing the heart as a bag of worms, begins as a loss of atrial contraction, ... the ventricular rate and results in a positive inotropic effect (Carey et al., 1998; Fauci, 1998) Digoxin decreases the rate of beating of the heart ventricles, the chambers of the heart that push...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... specifically linked to one of the major pathogenetic mechanisms of PD [5] Worthy of note is the complete disappearance of the VDAC-2 upon dopamine treatment This porin of the outer mitochondrial ... destained (1 · 10 50 lL of K3[Fe(CN)6] 30 mm and Na2S2O3 100 mm; · 10 100 lL of deionized water; · 20 100 lL of NH4HCO3 200 mm; · 20 100 lL of deionized water), dehydrated with acetonitrile (1 ... diameter 375 lm) at a flow rate of lLÆmin)1 Peptides were eluted at a flow rate of 200 nLÆmin)1 with a linear gradient from Solution A (2% acetonitrile; 0.1% formic acid) to 50% of Solution B (98% acetonitrile;...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... restricted to the base of the crypts, leaving the upper part devoid of signal Low levels of Adh1 mRNA were also observed in striated muscles of the tongue and upper part of esophagus, as well ... Notably, the levels of Adh3 mRNA were much lower than those of the other classes of investigated enzymes High levels of Aldh1 mRNA were found in the basal epithelial cell layers of esophagus with ... photomicrographs of corresponding sections at the same magnification High levels of Adh1 mRNA are observed in the epithelial cells at the base of the intestinal glands in rectum and moderate levels of Adh4...
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