the distinguishing function and advertising value of the trademark aspects of the critique of the european reform
Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx
... residues K8 and D72 are located near the crossing region of the helices, and the Nx atom of K8 is found ˚ at a distance of 6.2 A from the nearest side-chain oxygen of D72 Taking the functionally and ... neutralization of the effect of the mutation D72K on the protein’s global charge was not sufficient to fully reverse the negative effect on the stability of cyt c6 The apparent stability of the mutants ... the mutation of surface residues located far from the heme moiety Thus, the thermodynamic driving force for the reaction of cyt c6 with PS I was essentially unaltered by the introduction of the...
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Báo cáo Y học: Function and cellular localization of farnesoic acid O -methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis ppt
... point in the regulation of MF biosynthesis, the biochemical and biological properties of the gene encoding the FAMeT have not been characterized Thus, the study of the enzymes of the MF biosynthetic ... of serial sections of the eyestalk revealed the presence of the FAMeT in the sinus gland, the X-organ neurosecretory cell clusters together with the lamina ganglionaries and the nerve fibers of ... controls (Fig 1A, II) The molecular mass of the detected rFAMeT band was 35 kDa, which was the expected size of the fusion protein Purification of rFAMeT and production and specificity of anti-rFAMeT...
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The auditor's loss function and investors' perceptions of audit effectiveness Effects of regulatory change
... by the accounting scandals of 2001 and 2002 was the reduction in the number of global audit firms What had been known in previous years as the Big 8, the Big 6, and the Big was reduced to the ... seriously the issue of auditor liability reform and possible liability caps These discussions, which have been led by the U.S Treasury’s “Paulson Committee”5, the U.S Chamber of Commerce, and by the European ... where the auditor limits the nature and extent of testing Because the majority of the public information on AS5 emphasized the efficiency benefits of the “relaxed” or “eased” auditing standard,...
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báo cáo hóa học:" Traumatic extremity arterial injury in children: Epidemiology, diagnostics, treatment and prognostic value of Mangled Extremity Severity Score" pdf
... limited by the number of patients and its retrospective design Especially, the retrospective application of the MESS to the treatment of paediatric vascular injuries before the development of the score ... injuries and isolated blunt extremity trauma the danger of subsequent deterioration due to the second hit of the operative procedure is negligible Furthermore, routine surgical revision of the soft ... a rupture of the axillary artery caused by a dislocation of the shoulder joint was seen The type and pattern of vascular injuries are presented in Table Location of vascular injuries The lower...
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Báo cáo khoa học: "Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40" ppsx
... concerning the status of nodal Sensitivity and specifity of the different methods for evaluation of lymphatic vessel invasion concerning the status of nodal metastasizing With the background of unknown ... thrombembolism of tumor cells The presence of the endothelium is needed for the success of this analysis Another reason is, that the conventional assessment cannot distinguish between lymphatic and blood ... 33% of tumors showing L1 defined from the results of either methods The value is higher than that from the results of only one examination, standard or immunohistochemical staining From these...
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Báo cáo y học: "Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis" doc
... all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis RS, JDC, and IH designed the study RS, EG, JAG-P, MLP, and MJG acquired the ... the importance of the aminoacyl environment of citrulline residues and the correct balance of Arg/Cit residues within the synthetic molecule This probably influences the adoption of a preferred ... synthetic chimeric fibrin/filaggrin peptides (CFFCP2, CFFCP3) and to compare their sensitivity and specificity in RA and other disease groups with the commercial CCP2 test The prognostic value of...
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Báo cáo sinh học: " Consensus genetic structuring and typological value of markers using multiple co-inertia analysis" pps
... figure, the location of each data point can be indicated using an arrow The tip of the arrow is used to show a location in the single marker analysis and the start of the arrow is the location of the ... point The barplot of eigenvalues is drawn at the bottom left It indicates the relative magnitude of each axis with respect to the total variance The higher the eigenvalue is, the higher the Euclidean ... between the scores of populations of the coordinated analyses, and the reference Let lr be the rth scores of populations in the coordinated %PCA of a marker k k (with ≤ k ≤ K) ,and vr be the rth...
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A study on structure, function and diachronic evolution of chinese extended middle construction
... Yang Lili and Wu Yayun, for their friendship and the happy days we have been together Finally, I would like to thank my parents, my sister and brother for their love, understanding, and patience ... STRUCTURE, FUNCTION AND DIACHRONIC EVOLUTION OF CHINESE EXTENDED MIDDLE CONSTRUCTION 蔡淑美 CAI SHU MEI (Ph D, NUS) 新加坡国立大学中文系 博士学位论文 A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... literature review on the current research of this construction, and briefly outline the organization of my dissertation The central claim of chapter two is that, although there exists disagreement...
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FUNCTION AND MECHANISM STUDIES OF TRPV4 IN BREAST CANCER METASTASIS
... knockdown of TRPV4 significantly reduced the number and size of metastatic nodules in the lungs of SCID mice These effects of TRPV4 knockdown were associated with a reduction in the plasticity of the ... invasion and transendothelial migration 3.2.2 Silencing of TRPV4 reduce the nodules’ size and number in the lungs of the mice 62 62 3.2 45 52 68 VI 3.3 Cellular and molecular mechanism of TRPV4 ... Among the TRP families, the expression levels and activity of some members of the TRPC, TRPM and TRPV families have been correlated with cancer, leading to the discovery of tumor-related functions...
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Catalysts development and mechanistic study of ethanol steam reforming for low temperature h2 production
... incorporation of Ca increases the availability of surface Ni which enhances the formation of coke via dissociation of CH4 Furthermore, the addition of Ca also influences the particle size of Ni which ... Dispersion and Degree of Reduction of Ni Catalysts 101 Table 5.2 TOFH2 of catalysts at 573 K, 673 K, 773 K and 873 K 102 Table 5.3 Intensity Ratio of the D and G bands (ID/IG) of Spent ... assist in the removal of coke deposits The addition of higher loading of calcium (i.e Ni/7 wt % Ca-Al2O3), however, deteriorates the stability of the catalyst and it performs even worse than the Ca-free...
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Benefits and unintended consequences of financial markets reform
... extending the reach of these derivatives reforms that their ability to hedge will suffer as a beyond their home jurisdiction, such as to overseas consequence of the Dodd-Frank reforms offices of domestic ... chart 5) The FS industry is underestimating the longterm costs of compliance—there will be problems down the line with the amount of work for compliance departments and the extent of reporting ... consequence of the Vickers Report The cost of compliance is the greatest worry Almost three-fifths (59%) of respondents see the increased costs of complying with the new regulations as the biggest...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18] ... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription of the ITK gene and is key for the productive infection of HIV in these...
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Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function pptx
... properties of trappin-2 involve the cationic nature of the molecule, as assessed from the salt and heparin dependence of the antimicrobial and antifungal effects Results Antimicrobial effects of recombinant ... We then examined the effect of heparin on the antimicrobial 2012 Fig Western blot analysis of elafin and trappin-2 fractionated on heparin-Sepharose The heparin-binding capacities of elafin and ... (+7) or elafin (+3) and also binds heparin, is blocked in the presence of 0.15 m NaCl [10] The differences in the distribution of positive charges on the surfaces of elafin and SLPI molecules [1]...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
... demonstrates the inter-connectedness of the low and high latitudes, and the global nature of the Earth’s hydrologic cycle Our case studies provide glimpses of wetland ecosystems, which expanded and ultimately ... archive of the species that grew in and near the wetland If the rate of organic matter accumulation exceeds the rate of decomposition in such a wetland environment, then a temporal component to the ... change because of the resistance of pollens and spores to decay, and their ubiquity and abundance (Traverse 2008) Wetlands are excellent sources of pollen and spores and like macrofossils, palynomorph...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... ether strands mimic the distance between the nucleobase and the diphospho-bridge, but on the other hand likely are involved in polar interactions with the cADPR receptor protein Certainly, the ... northern and southern riboses are primarily necessary as linkers between the base adenine (or hypoxanthine) and the diphospho-bridge, as they can be replaced by much simpler ether strands These ... (Fig 4; [46]) An even stronger modification of the original molecule cADPR was achieved by substitution of both the northern and southern ribose by ether strands, resulting in N1-[(phosphoryl-O-ethoxy)-methyl]-N9-[(phosphorylO-ethoxy)-methyl]-hypoxanthine-cyclic...
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... description of recent advances in the understanding of the channel-, motor- and regulatory components of the Tic complex For reference, some of the available knowledge, including the proposed function of ... which anchor the protein in the membrane The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic ... Additionally, because the demand of the chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin of the signal, and thus regulation at the Tic complex could be one of the fastest...
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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... isotherms with best-fit Kd values of 22 ± 1.5 and 24 ± 2.6 mM for WT and DK9 thrombin, respectively The vertical bars are the standard errors of the measurements 162 compared with those of the ... of Trp207 and 29 may significantly affect the intrinsic fluorescence of the DK9 variant, the higher the surface exposure and flexibility of their side-chains to the solvent the smaller the intrinsic ... (2–4) Global and simultaneous analysis of the experimental data by grafit software allowed computation of the pKa values of the two groups both in the free and substrate-bound species of thrombin...
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The Social Discount Rate, Cost of Public Funds, and the Value of Information pptx
... decrease the ffects of the tax rate increase on the quantity of labour supplied and he quantity of leisure demanded Estimates of the marginal cost of public funds: In Australia and other OECD ... prevails q is the probability of the high price prevailing (1-q) is the probability of the low price prevailing r is the rate of interest The expected value of information is: The expected project ... result of the increase in tax rate; • the quantity of labour supplied falls from L0 to L1 because of the upward sloping supply curve The cost to households of the tax increase is the loss of producer...
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Báo cáo khoa học: An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum Cloning and biochemical characterization of the enzyme potx
... only 26% between the two enzymes On the other hand the structure appears to be similar to that of Pf LDH with a rmsd of 0.8 between the Ca atoms (Fig 5) Both the cofactor and the substrate binding ... the differences the substrate specificity loop is coloured green in the case of Pf LDH and red in the case of Pf MDH Comparative expression of Pf MDH, Pf LDH and Pf MQO and effect of gossypol The ... the DISCOVER module of INSIGHTII 2000 The geometric and local environmental consistency of the model was evaluated with the PROSTAT and PROFILES-3D [31] modules of INSIGHTII 2000 as well as the...
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Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx
... models of GPCR–b-arrestin interaction (A) The sequential binding of the ligands to each half of the receptor dimer induces the recruitment of two molecules of b-arrestin and then the activation of ... realistic measure of the ligand affinity for the hetero-oligomer At most, it may represent an average measure of all the different affinities that the ligand expresses for the binding site(s) of both hetero-oligomers ... separately and then allowed to interact To understand the mechanism by which these bivalent ligands work, the structural organization of GPCR oligomers in the plasma membrane needs to be clarified The...
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