role of prefrontal cortex dopamine and noradrenaline circuitry in addiction
Role of environmental self-auditing and audit policies in regulatory compliance
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Báo cáo khoa hoc:" Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)" ppt
... gel, was incubated with units of exonuclease I (Amersham Biosciences) and unit of shrimp alkaline phosphatase (Amersham Pharmacia) in order to digest remaining primers and to inactivate unincorporated ... hypothesis of dominant or loss-offunction mutations like those found in HOXD13 [31,32] and seems to show that quality of the corresponding proteins, if correctly expressed, can not be incriminated Interestingly, ... also expressed in the developing kidney [21] and are both required for correct patterning of the skeleton [22] HOX proteins share in common a highly conserved 60 amino acid DNA binding motif referred...
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ROLE OF VOLTAGE-DEPENDENT K+ AND Ca2+ CHANNELS IN CORONARY ELECTROMECHANICAL COUPLING: EFFECTS OF METABOLIC SYNDROME
... more investigated candidates include components of the reninangiotensin-aldosterone system (RAAS) Notwithstanding the systemic and renal influences of these hormones, angiotensin II (AngII) and ... surprising given the growing rate of obesity and it’s associated co-morbitities that the incidence of cardiovascular disease and mortality is also rising Accordingly, determining the role for KV and ... degree of insulin 22 resistance (179; 290), and the clinical diagnosis of MetS (246) Interestingly, our data indicate that specific receptor subtypes and downstream K+ channels involved in coronary...
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the role of supply chain processes and information sharing in supply chain management
... supply chain information into supplier information, manufacturer information, distribution and retailer information, and demand information Handfield and Nichols (1999) classified supply chain information ... does the value of information sharing change as the number of supply chain members participating in information sharing change? The study shows that the value of information sharing increases as ... (Supply Chain Council, 2000) The “Plan” process in the SCOR model includes forecasting supply chain demands and coordinating different players in a supply chain The supply chain planning process...
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The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury
... pro-domain (Pro), which contains a zinc ligating thiol (–SH) group, and catalytic domain, which contains a zinc ion (Zn2+) Hemopexin-like domains are essential in binding to tissue inhibitors of metalloproteinases ... and thrombomodulin protein markers in the BALF and protein leakage into the airspaces We show here that oral administration of a low dose of doxycycline, a MMP inhibitor which inhibits gelatinases ... post-infection timepoint (in vivo experiment) 161 Absolute intensities of bands obtained from densitometric analyses of MMP-2 Western blot bands for control uninfected and influenza virus-infected...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1–CFP and D2R1–YFP – genetic variant of dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein ... Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1MUT–CFP – genetic variant of dopamine D1 receptor and D2–YFP) g Measured in cell co-expressing dopamine D1 and D2 fusion proteins ... protein (D1–CFP and D2R2–YFP – genetic variant of dopamine D2 receptor) e Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1–CFP and D2R3–YFP – genetic variant of dopamine D2 receptor)...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... signatures in the sequences are present in both proteins, tyrosinases and catechol oxidases; these include the six histidine residues involved in the binding of a pair of copper ions and other ... browning of fruits and vegetables, and morphogenesis and fruiting body formation in fungi All of these processes involve melanin formation In the bacterial kingdom there are some examples of wellcharacterized ... found two different genes in R solanacearum coding for putative PPO proteins that contain the typical signatures of tyrosinases, including the CuA and CuB binding sites to ligand the copper FEBS Journal...
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Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt
... the N-terminus of helix Na3 [3]; (b) two histidines (H298 and H333), promoting decarboxylation of malonyl and H333 also playing a role in the condensation reaction and for the pKa value of the nucleophile ... octahedrally co-ordinated in the vicinity of the active site (Fig 2) Three of the six cation ligands are main-chain oxygen atoms, and three are the side-chain oxygen atoms of N296, E342 and S387 The ... weak, binding of ACP to the docking site followed by a conformational change in ACP proposed to inject the acyl chain into the substrate-binding pocket [32] If a similar mechanism is involved in...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... protein was organized from its polypeptide chain into N-terminal and C-terminal centers during refolding [21] Since then, many scientists have been interested in demonstrating this concept by using ... nuclease refolding investigated Two point-mutated proteins, with a single base substitution of alanine for tryptophan (W140A) and alanine for lysine (K133A), and two truncated fragment proteins, with ... important role in maintaining protein tertiary integrity Figure 4A shows how tryptophan (loop 1) may interact with loop and loop These interactions seem to form a ‘lower neck’ in the protein as compared...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
... (chain A), 266–295 (chain B) and 385–399 (chain C) in SmPALout ⁄ in and 33–128 and 333–351 (chain A), 272–303 (chain B) and 293–306 (chain C) in PlPALout ⁄ in The preoptimizations and molecular dynamics ... Active-site-binding ligands (e.g amino-oxyphenylpropanoic acid (E)-cinnamate, o-tyrosine) protected the R glutinis PAL from inactivation by the three proteinases, and peptide-bond cleavage by trypsin and ... phenylalanine 2,3-aminomutase (PAM) involved in taxol biosynthesis in Taxus chinensis [27] or T cuspidata [28] and tyrosine 2,3-aminomutase (TAM), which is involved in biosynthesis of a natural...
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Báo cáo " Cell suspension culture Panax ginseng C. A. Meyer: Role of plant growth regulators and medium composition on biomass and ginsenoside production " docx
... cells of P ginseng were maintained in MS medium The cultural conditions were done as described by [8] Determination and analyses Extraction and determination of ginsenoside production were determined ... of the hormone concentration and combination are often effective For ginseng cell growth, 2,4 D is most commomly used in routine culture maintenance [6] But use of this suspected carcinogen often ... mg/g DW total ginsenoside) of ginseng suspension culture Addition of cytokinins (BA and kinetin) did not affect cell growth but ginsenoside productivity (particularly Rb group) was increased when...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... evidence of correct pairing of the interchain disulfide bridges in the recombinant sample [11] The kinetics of the N-terminal arms swapping in the P19A-BSRNase is comparable to that of BS-RNase ... mutation of two paradigmatic residues involved in the dislocation of BS-RNase N-terminal arms, i.e Pro19 and Leu28, located in the hinge peptide and in the intersubunit interface, respectively CD and ... differential scanning microcalorimetry, and an investigation of the kinetics of swapping of all variant dimers in comparison with that of the parent protein mutations are underlined) For the mutant...
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Neural Tube Defects – Role of Folate, Prevention Strategies and Genetics Edited by Kannan Laksmi Narasimhan ppt
... important role in the metabolism of several amino acids, which are the building blocks of proteins Tetrahydrofolic acid is involved in the formation of purines (adenine and guanine) and pyrimidines ... grandparents Doolin et al (2002) assessed associations between maternal and offspring MTR and MTRR genotypes and spina bifida using the two-step TDT and using a log-linear The Role of Folic Acid in the ... used in chemotherapy and a synthetic derivative of pterin, and works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase Its binding affinity...
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Báo cáo khoa học: Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids Kohsuke Honda, Michihiko Kataoka, Eiji Sakuradani and Sakayu Shimizu doc
... ligase and Ex Taq DNA polymerase were from Enzyme assay, SDS/PAGE and protein determination Acinetobacter strains and the recombinant E coli strains were cultured in mL LB medium For cultivation of ... proteins in the protein sequence database (see text for details) Arrows indicate the direction and extent of sequence determination led to the identification of a single recombinant clone harbouring ... The resulting plasmid, named pDHEB, contains the gene encoding DCH lacking the C-terminal region, in which Asp and His residues involved in the catalytic triad are contained The kanamycin resistance...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis J Mol Biol 269, 129–141 32 Perham, R.N (2000) Swinging arms and swinging domains in multifunctional ... reactivity of its dithiol/ disulfide group, as it allows thioredoxin to participate in a number of redox processes in vitro Study of crossreactivity of thioredoxins and potential target proteins from ... of protein-protein recognition Proteins 28, 153–161 Hanine, L.C., El Conte, D., Jacquot, J.-P & Houee-Levin, C (2000) Redox properties of protein disulfide bond in oxidized thioredoxin and lysozyme:...
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Báo cáo "The role of color luminescence centers Mn, Cu, Co in the semicondutors with wide band gap ZnS, ZnO and their applications " pptx
... band is greater than that of the blue band As increasing the concentration of Cu, the intensity of the blue band decreases while the intensity of the green band increases and reaches to maximum ... Journal of Science, Mathematics - Physics 24 (2008) 181-187 When doping Cu, Mn in ZnS and Co in ZnO, the self-activated luminescence bands characterized by vacancies of zinc and oxygen are extinguished ... positions of Zn2+ ions or vacancies of Zn in ZnS crystal With increasing of concentration of Cu beyond 3.5.10-4 mol%, the intensity of the green band decreases Because at high concentration of Cu,...
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Role of C-Reactive Protein and Procalcitonin in Differentiation of Tuberculosis from Bacterial Community Acquired Pneumonia potx
... examination, and radiographic findings Therefore, CRP and PCT might have a role in the diagnostic algorithm as rapid, noninvasive tests No difference was observed in the discriminating power of ... Usefulness of procalcitonin as a marker of systemic infection in infection: a systematic review and meta-analysis Clin Infect Dis emergency department patients: a prospective study Clin Infect 2004;39:206-217 ... variable time interval from the onset of symptoms before evaluating PCT and CRP might have affected the results because of the kinetics of each inflammatory marker [29,30] Considering this point, a...
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WORKING PAPER NO. 218 THE ZERO-INTEREST-RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN potx
... nominal interest rate is well above zero, the central bank can ease monetary policy by expanding the supply of the monetary base and bringing down the short-term rate of interest Since prices of ... that increasing the Marshallian K by one percentage point would be associated with a decline in the shortterm nominal rate of interest of about four percentage points However, increases in the ... lower-left and lower-right panels in Figure indicate the upward bias in the standard deviation of output and in ation as a function of the equilibrium nominal interest rate For example, for an i∗ of...
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Báo cáo khoa học: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth* potx
... neurotransmitter transporters and are involved in Na+ binding [19] Also present are conserved residues D32 in the rst TMD and S321 and S324 in TMD7, thought to be involved in catecholamine binding [20] There ... uptake in each replacement saline was normalized to uptake in control saline containing 100 mM Na+ and 92.7 mM Cl DA uptake by TrnDAT-expressing cells in salines in which equimolar K+, Li+, choline+ ... complete list of the compounds tested is given in Table Nisoxetine, nomifensine, and several dibenzazepines (desipramine, Table Inhibition of [3H]DA uptake by caterpillar DAT and OAT and other invertebrate...
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The role of health related, motivational and sociodemographic
... fields of food labels In Switzerland, labels in the form of nutrition tables are the standard form of food labelling, although recently front -of- package labels have been appearing more and more in ... crucial determinants of label use in order to promote label use On the one hand, as an interest in health and healthy eating seems to be the central element in determining the frequency of label use, ... clarify the role of sociodemographic variables in label use by including all main predictor variables that have been investigated separately in one model Following this procedure, we intend to investigate...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008