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NEURAL TUBE DEFECTS
– ROLE OF FOLATE,
PREVENTION STRATEGIES
AND GENETICS
Edited by Kannan Laksmi Narasimhan
Neural Tube Defects – Role of Folate, Prevention Strategies and Genetics
Edited by Kannan Laksmi Narasimhan
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors
and not necessarily those of the editors or publisher. No responsibility is accepted for the
accuracy of information contained in the published chapters. The publisher assumes no
responsibility for any damage or injury to persons or property arising out of the use of any
materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Petra Nenadic
Technical Editor Teodora Smiljanic
Cover Designer InTech Design Team
First published March, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Neural Tube Defects – Role of Folate, Prevention Strategies and Genetics,
Edited by Kannan Laksmi Narasimhan
p. cm.
ISBN 978-953-51-0317-2
Contents
Preface IX
Part 1 The Role of Folic Acid
and Prevention of Neural Tube Disease 1
Chapter 1 The Role of Folic Acid
in the Prevention of Neural Tube Defects 3
Lourdes García-Fragoso,
Inés García-García and Carmen L. Cadilla
Chapter 2 Strategies for Prevention of Neural Tube Defects 31
Hiroko Watanabe and Tomoyuki Takano
Chapter 3 Primary Prevention of Neural Tube Defects 47
Claudine Nasr Hage and Grace Abi Rizk
Chapter 4 Prevention of NTDs – Proposal of a New Concept 65
Prinz-Langenohl Reinhild,
Pietrzik Klaus and Holzgreve Wolfgang
Chapter 5 Antenatal Prevention of Neural Tube Defects 91
Naomi Burke, Tom Walsh and Michael Geary
Chapter 6 Selective Abortion
and Folic Acid Fortification as Contrasting Strategies
for Prevention of Congenital Neural Tube Defect 98
John A. A. Nichols
Chapter 7 Folate and Prevention of Neural Tube Disease 117
Ramya Iyer and S. K. Tomar
Part 2 Genetics of Neural Tube Defects 139
Chapter 8 Advances in Genetics
of Non Syndromic Neural Tube Defects 141
Patrizia De Marco
VI Contents
Chapter 9 Neural Tube Defects in Algeria 163
Bakhouche Houcher, Samia Begag, Yonca Egin and Nejat Akar
Chapter 10 Association of A80G Polymorphism in the RFC1 Gene
with the Risk for Having Spina Bifida-Affected Offspring in
Southeast Mexico and Interaction with C677T-MTHFR 179
Lizbeth González-Herrera, Orlando Vargas-Sierra,
Silvina Contreras-Capetillo, Gerardo Pérez-Mendoza,
Ileana Castillo-Zapata, Doris Pinto-Escalante,
Thelma Canto de Cetina and Betzabet Quintanilla-Vega
Part 3 Surgical Treatment
of Large Thoraco-Lumbar Neural Tube Defects 191
Chapter 11 Treatment of Large
Thoraco-Lumbar Neural Tube Defects 179
Mehrdad Hosseinpour
Preface
The book Neural Tube Defects - Role of Folate, Prevention Strategies and Genetics has
several eminent international authors and the book is a resource for anybody who is
interested in this very important subject. The book has been divided into 3 sections;
The role of Folic acid and prevention of Neural Tube disease which has seven
chapters. Genetics of Neural Tube Defects having 3 chapters and a Surgical Treatment
of Large Thoraco-lumbar Neural Tube Defects which includes a chapter on surgical
treatment of large lumbo - sacral defects. The authors are distinguished and the
chapters are a product of their extensive research.
I am glad that Intech took the initiative to publish this book for online free access.
Dr. Kannan Laksmi Narasimhan
Consultant in Ped Surgery,
KK women's and children's hospital,
Bukit Timah Road,
Singapore
. NEURAL TUBE DEFECTS
– ROLE OF FOLATE,
PREVENTION STRATEGIES
AND GENETICS
Edited by Kannan Laksmi Narasimhan
Neural Tube Defects.
Neural Tube Defects – Role of Folate, Prevention Strategies and Genetics
Edited by Kannan Laksmi Narasimhan
Published by InTech
Janeza Trdine
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