role of civil society organizations in sustainable development
Tài liệu SICK WATER? THE CENTRAL ROLE OF WASTEWATER MANAGEMENT IN SUSTAINABLE DEVELOPMENT pdf
... dis-charge can contain a wide range of contaminants and originate from a myriad of sources. Some of the biggest generators of toxic industrial waste include mining, pulp mills, tanneries, sugar ... from mining operations can contain silt and rock particles and sur-factants. Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, ... examples of persistent environmental damage caused by the discharge of toxic mine waste. In Papua New Guinea for ex-ample, companies discharge millions of tons of contaminated mine waste into...
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Tài liệu Constructing Civil Liberties Discontinuities in the Development of American Constitutional Law pdf
... criminal pro-cess rights. In resisting the progressive program concerning prohibition, theCourt played a major role in inventing the modern constitutional doctrine of criminal procedure. In ... chart these developmental dynamics.The following synopses begin with a description of the familiar Whiggishnarrative of development concerning each site. Taking account of patterns of intercurrence, ... picture of trajectories of constitutional development concern-ing twentieth-century civil rights and civil liberties.Each of these chapters involves a sustained consideration of a “site” of constitutional...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern ... providing assistance to disadvantaged businesses in securing PennDOT contracts Impact of University OperationsInvestments in higher education help create sustainable economic development leading ... $28,000 in average annual salary)Preserving ValueContinuing education is important to preserving the market value of specialized education – particularly in professional fieldsContinuing education...
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Báo cáo y học: " Role of Dietary Soy Protein in Obesity"
... Ten proteins were detected as IgE-binding proteins and 8 proteins as IgG4-binding proteins, with high IgE de-tection rate and specificity. Among the IgE-binding proteins, the proteins with ... changes in fat intake since the amount of dietary fat (30% of total energy) was main-tained constant during the intervention. Similarly, in a 4-week randomized dietary intervention trial of male ... food intake and gastric emptying [69]. These effects were attributed in part to an increase in circulating levels of cholecystokinin. Similarly, in rats fed a hy-percholesterolemic diet, ingestion...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... echo-planar MR imaging andADC mapping in the differential diag-nosis of ovarian cystic masses: useful-ness of detecting keratinoid substances in mature cystic teratomas. J MagnReson Imaging 22:271–27824. ... 2008Published online: 7 October 2008# European Society of Radiology 2008 Role of diffusion-weighted imaging in the diagnosis of gynecological diseasesAbstract Recent technical advances in diffusion-weighted ... the future of MRI in patients withgynecological diseases.Examination of the female pelvic region using DWIDWI is obtained by measuring signal loss after a series of two motion-providing gradient...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... targeting of CYP2E1The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. Thefirst approach involved measuring the level of mito-chondrial targeting of wild-type ... importance of PKA in protein trafficking [47,48]. In this study, we usedPKA knockout mutants to determine the role of PKA in mitochondrial targeting of CYP2E1. In mutantslacking PKA, CYP2E1 was ... were resuspended in SEMbuffer containing indicated concentrations of digitonin(0.05% to 0.4%, w ⁄ v) for 30 min on ice with occasionalmixing. Digitonin-soluble and digitonin-insoluble fractionswere...
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Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
... double-chaininsulin is synthesized in vivo as a single-chain precursor(preproinsulin) and folded as proinsulin, in which aconnecting peptide of 35 residues links the C terminus of the B chain and ... Sciences, Chinese Academy of Sciences, Shanghai, ChinaWe have investigated the in vitro refolding process of humanproinsulin (HPI) and an artificial mini-C derivative of HPI(porcine insulin precursor, ... character-ization of the unfolding of insulin and proinsulin using thereductive unfolding method has not been thoroughlyinvestigated. We have characterized the unfolding process of an artificial porcine insulin...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... fosfomycin binding due to charge–chargerepulsions. Most interestingly, the uncharged valine sidechain completely abolishes fosfomycin binding in theabsence of UDPNAG. Clearly, UDPNAG binding createsadditional ... notinteract with R124 in the ternary complex [20]. Hence, themechanism of binding of fosfomycin by reinforcement of aninitial binding site (mainly K22 and R397) through recruit-ment of secondary ... Lysine 22 and arginine 120 in MurA (Eur. J. Biochem. 271) 2685 the positively charged side chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... thebovine complex a large subdomain is made up of 20integral membrane proteins contributing > 60 transmem-brane segments. Some of these must be intimately involved in proton pumping. Another ... one might expect a protein to be insertedinto the inner membrane, but it is missing a major portion of the domain localized in the intermembrane space. Acomparison of all the known mammalian...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... family of thiolate-ligatedconstitutive or inducible hemoprotein isoforms [281],exhibiting insign ificant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminalflavoprotein ... B. (1994) The pteridine b inding site of brain nitric oxidesynthase. Tetrahydrobiopterin binding k inetics, specificity, andallosteric interaction w ith the substrate d omain. J. Biol. Chem.269, ... cis-dihydroxylation of a romaticrings, in itiating aerobic degradation of aromatic compounds in soil bacteria, and are targets for bioengineering in bioremediation [204]. They a re a consortium of two o...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... periods of times (0–60 min)at 37 °C. The concentration of the biotinylated Ig remainingon the cell surface was then quantified by measuring thebinding of [125I]Streptavidin. In the absence of ... Theywere then incubated with 0.25 mL of incubation mediumcontaining 2 lgặmL)1 of biotinylated R5T-34 monoclonalIg [30] at 4 C for 30 min. In some cases, monensin 40 lMwas added to the incubation ... domain and devoid of any tag was notfunctional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag wasfound constitutively activated [29]. In agreement...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... thisprotease at pH9 [10]. Further interest in the aromaticstacking is in the role of the electrostatic properties in enzymatic catalysis of API, and in distinguishing thefunctionally catalytic ... CH/, p interaction in thepacking of the adenine ring in protein structures. Advan. ProteinChem. 39, 125–189.20. Brandl, M., Weiss, M.S., Jabs, A.S., á hnel,J.&Hilgenfeld,R.(2001) CH p-interaction ... a new way of thinking aboutthe functional role of the former ionizable aromatic aminoacid. The pH optimum mechanism in API results from twothings: (a) positively charged His210 interacts with...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... respectively. By introducing an Ala residue in the place of Gly it is expected that the conformational flexibility of themain chain can be constrained with a minimum perturba-tion of the local structure, ... our incomplete under-standing of the relation between enzyme properties andconformational flexibility limits the exploitation of the fullpotential of protein engineering in the redesign of psychro-philic ... the basis of side-chain packing criteriafrom a modelled structure of the enzyme resulted in restor-ation of the energy of activation to the levels of the nativeenzyme and in an increased stability...
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Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf
... during photoreceptor development when compared with the patterns of binding of Nrl tothe rhodopsin promoter (Fig. 4C,D). The mRNA tran-script levels of Ppp2r5c and rhodopsin in mouse retinacorresponded ... analyzedwith a motif searching program to identifybinding sites of transcription factors.Consensus binding sites are underlined, theNrl-binding site is printed in bold, and thetranscription ... cells, to further examine thebinding of Nrl to the Ppp2r5c promoter in vivo. Nrlbinding to the Ppp2r5c and rhodopsin promoters wasexamined by quantitative real-time of ChIP sampleswith appropriate...
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HUMAN PERFORMANCE: Role of General Mental Ability in Industrial, Work, and Organizational Psychology docx
... FactorProcessing information (perceiving, retrieving,manipulating, transmitting)Compiling information, importance of 0.90 Seeing (DOT) 0.66 Work with complex thingsCombining information, importance of ... importance of 0.36Practical problem solvingAdvising, importance of 0.86 Supervising nonemployees, importance of 0.64 Catering to peoplePlanning and scheduling, amount of 0.83 Catering and serving, ... Catering to peopleMath, level of (DOT) 0.79Math, level of 0.70Quantitative information, extent of use 0.68Coding and decoding, importance of 0.68Oral information, extent of use 0.68Talking...
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