rnase h likely corresponds to the cellular dna binding site of hiv 1 in
Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... model that uses HIV- 1, the currently best approach to unravel such questions about HIV- 1 RT is the use of macaques infected with RT-SHIV, a chimeric virus consisting of SIVmac239 in which the RT ... depletions) that enable the study of mechanisms that would otherwise be difficult to unravel, and that are relevant to the clinical use of tenofovir-containing regimens in HIV- 1 infected humans In the ... This RT-SHIV stock had a titer of 10 5 50% tissue culture infectious doses (TCID50) per ml This RT-SHIV stock had the T to C substitution at position of the SIV tRNA primer binding site, which...
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Báo cáo khoa học: "METONYMY: REASSESSMENT, SURVEY OF ACCEPTABILITY, AND ITS TREATMENT IN A MACHINE TRANSLATION SYSTEM S" ppt
... Johnson 19 80, Yamanashi 19 87) seem to be obtained from the intuition of the analysts However, we think that the patterns which are based on the analysts' intuition to begin with should be ... which corresponds to the original form, then the system should produce a direct translation since the translation preserves the naturalness However, if the 310 The sign said fishing was prohibited ... languages show acceptance in the group to which the expression belongs to in the result of the survey, the system should accept it for analysis, and come up with some metonymic reading using its inference...
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Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx
... Journal of Translational Medicine 2 011 , 9 :11 1 http://www.translational-medicine.com/content/9 /1/ 111 Moreover, the expression of Phospho-Bad, one of the anti-apoptotic indicators, was increased in ... immune pathway in disease pathology [38] In this study, we found C5a induced Th17 cytokine expression from human T cells in vitro, which correlates with the increased levels of Th17 cytokines in AMD ... elevated in AMD patients compared with controls We then subgrouped cytokine expression in both the controls and Page of 12 the AMD patients based on their CFH SNP information (rs10 611 70) As shown in...
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báo cáo hóa học: " Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene" ppt
... other means 11 12 13 14 15 16 Competing interests The author(s) declare that they have no competing interests Authors' contributions SF carried out the histopathological studies and drafted the ... mediators in the CNS and as such are thought to be potentially neurotoxic [13 ,14 ] Chronic neuroinflammation is thought to be involved also in the pathogenesis of ALS based on a variety of in vivo ... target of HIV- 1 in the brain it is thought that presence of virus within microglia causes the Page 10 of 12 (page number not for citation purposes) Journal of Neuroinflammation 2007, 4:9 http://www.jneuroinflammation.com/content/4 /1/ 9...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... 5-24* 01 VH3-74* 01 VH4-4*03 VH4-30.4* 01 2-2* 01 VH4-34* 01 VH4-59 1- 26* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 4-4* 01 5*02 B C D VH3-07 VH3-23 VH3-33 VH3-72* 01 VH4-59*02 VH5- 51* 01 VH5- 51* 01 2 -15 ... 4*02 1- 26* 01 VH2-5*02 VH3- 21* 01 VH3-30*03 2-8* 01 VH3-30*03 2-8* 01 VH3-30.3* 01 3-3* 01 VH4-30 .1 2-2* 01 5* 01 VH2-5*02 VH3 -15 * 01 VH3- 21* 01 VH3-23* 01 VH3-23* 01 3 -10 *02 VH3-30*03 VH3-30*03 VH3-33* 01 5-24* 01 ... within the GCs themselves but they were loosely distributed in the surrounding tissue within close proximity to the GCs (data not shown) The immunohistochemistry also demonstrates that both GCs...
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báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... event in the development of HCC seems to be the abnormal regulation of the transcription factor b-catenin, a key component of the Wnt signaling pathway [58] In the normal state, the binding of members ... seeded into the liver tissue by BMDC and can modify cell phenotype mimicking the one of resident cells in the host tissue Insults trigger the release of chemokines from the endothelium inducing adhesion ... cocultured with endothelial cells, significant induction of endothelial cell apoptosis occured In this respect, their findings are in Page of 11 agreement with those of other authors who have demonstrated...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... even though there was double the mast cell density in the latter muscles Discussion In this study a tourniquet was placed high up on the thigh to induce a short warm (36°C) ischaemia of 70 minutes ... even though the latter contained twice the density of mast cells, indicate that there is also a genetic component to IR injury Our data would support the hypothesis that there is a base line level ... respectively in the absence of mast cells, indicating that other factors, possibly related to muscle type contribute to the IR injury The demonstration that muscles from the C57/C57 and C57/DBA strains of...
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Báo cáo y học: " Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patients" potx
... conception, the design of the study, and the drafting of the paper HJ has been involved in drafting and revising the paper HK has been responsible for testing the serums GP has been responsible for the ... into the HCV dynamics, the mechanisms of action of interferon as well as the consequences of varying dosages of interferon [14 ] The high turnover rates of HCV explain the rapid generation of viral ... observed in out of the patients with SVR and in only out of the 11 other patients Other studies have reported the same observation at week [18 -20], whereas Zeuzem et al reported that the absence of...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... previously The fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker introduced leucine and valine residues N-terminal to the MUC3 ... replace the SEA domain of MUC1 with those of MUC3 or MUC12, XcmI sites were used to remove 11 1 amino acids from V128 to A238 of MUC1FDTR These were replaced by 11 8 amino acids from D 61 to S178 of ... and others, have detected multiple forms of the cytoplasmic tail of MUC1, MUC1FDTR and its derivatives [9 ,13 ] Further, the migration of the CT2-reactive forms of the hybrid mucins shown in the...
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Child-friendly health care: the views and experiences of children and young people in Council of Europe member States doc
... roughly four out of five children saying that they were given the information they wanted at their appointment with their health care professional, that they understood this information, that they ... Question 15 asked the children whether they understood what the health care professional said to them The experience here was mixed In particular, 38.3% said that they understood all of what was ... At the appointment Question 13 asked about the appointment with the health care professional and the child’s experience Firstly, it asked whether the child had time alone with the person they...
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Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... degradation, thereby leading to inactivation of the HSPG -binding sPLA2s [34,35] Thus, in addition to their enzymatic characteristics, the HSPG -binding properties of sPLA2s also dictate their cellular behaviors ... of which is their high affinity for heparanoids [7 12 ] The major heparin -binding site of sPLA2-IIA is located near the C-terminus, where a highly localized site of basic residues affects its heparanoid ... V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils: a potential role of heparin sulfate binding in PLA2 internalization and degradation J Biol Chem 276, 11 126 11 134...
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Báo cáo khoa học: Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-b gene promoter docx
... context, which refers both to the specific arrangement of the cis-acting elements in the promoter and to the nature of the factors they bind To investigate the effect of promoter context on the transcriptional ... resulting in binding to more than 1. 5% of input are shown IRF-3 and IRF-7 each bind with much higher affinity to the ISRE of IFN- and virus-inducible genes than to the P 31 sequence within the IFN-b ... two copies of P 31 driving the expression of the CAT reporter through the E1b TATA box This artificial context isolates the contribution of P 31 from that of PRD IV and PRD II In the )11 0IFNbCAT...
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Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx
... P1(SEC14) P2(SEC14) KP1(SEC14) KP2(SEC14) P1(SFH1) P2(SFH1) KP1(SFH1) KP2(SFH1) F(SFH1-EGFP) R(SFH1-EGFP) P1(SFH2) P2(SFH2) KP1(SFH2) KP2(SFH2) F(SFH2-EGFP) R(SFH2-EGFP) P1(SFH3) P2(SFH3) KP1(SFH3) ... free choline into PtdCho via the CDP-choline pathway [6] On the other hand, strains bearing the cki1 mutation have a strongly reduced capacity to incorporate [14 C]choline into PtdCho during the ... underlined Location 5¢ upstream of SFH1 Name SFH1/1D SFH1/1R Downstream of SFH1 SFH1/2D SFH1/2R Control primer 5¢ upstream of SFH1 SFH1/3D Control primer inside SFH1 SFH1/3R 5¢ upstream of SFH2 SFH2/1D...
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Tế bào gốc và ứng dụng trong y sinh học (Stem cells and the application in biomedicine) potx
... bào thần kinh vi tóm lại Nghiên cứu tế bào gốc cho biết thể đợc h nh thành, phát triển từ tế bào nh tế bào khoẻ mạnh bình thờng thay cho tế bào bị tổn thơng nh thể cá thể Lĩnh vực khoa h c đầy ... dịch bệnh nhân bị ức chế nhng không bị phá huỷ hoàn to n Theo dõi mọc ghép tế bào ngời cho thấy phát triển tạo máu trở lại bệnh nhân vòng tháng Những tế bào gốc tạo máu có hoạt tính chống khối ... chế tổn thơng Gần phát thấy tế bào gốc não cá thể trởng thành phát triển thành tế bào thần kinh tế bào đệm Phát mở hy vọng tìm phơng pháp sửa chữa tổn thơng h thống thần kinh trung ơng Nghiên cứu...
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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt
... compared the binding of Sigma-2 ligands to the normal human pancreas cell line HPDE As demonstrated in Figure 1, Panel A, there is a high affinity of Sigma-2 ligand to the human pancreatic adenocarcinoma ... inhibitors like caspase inhibitor [13 ] While the anti-tumor effects of sigma-2 ligands alone are modest, the high receptor abundance on cancers and the high affinity of the ligands for the receptor ... suggest that SV 119 may serve as a sensitizer to these conventional therapies The pro-apoptotic activity of the sigma-2 ligand, SV 119 , is enhanced by conventional chemotherapy in vivo without cytologic...
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báo cáo hóa học: " Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia" docx
... considering the work of Shearer et al [52] in which they observed lower Ca2+ concentrations in the hair of autistic population and that of Krey and Dolmetsch [53] in which they proved that some forms of ... participated in the design of the study All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: 28 May 2 011 Accepted: ... barrier [46]; thus the administration of LPS to fetal sheep results in the extravasation of plasma proteins and macrophages into the brain [46] TNFa and IL6 are cytokines involved in cell-mediated...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... stage to heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing phase, and increases expression of ... this is in agreement with findings of others that demonstrated IGF -1 to be a major factor in bone mineralization [ 31- 33] using the IGF -1 null mouse In contrast, in cells treated with BMP-2, the ... efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of the dishes (Table 1) Rate of proliferation was dependent on the specific...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... stage to heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing phase, and increases expression of ... this is in agreement with findings of others that demonstrated IGF -1 to be a major factor in bone mineralization [ 31- 33] using the IGF -1 null mouse In contrast, in cells treated with BMP-2, the ... efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of the dishes (Table 1) Rate of proliferation was dependent on the specific...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25