rational design of dna anticancer agent that targets signal transducer and activator of transcription 3 stat3 for cancer therapy
Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... vectors for gene therapy Gene Ther 20 03; 30 4: 23- 33 86 Abbondanzo SJ, Gadi I, Stewart CL Derivation of embryonic stem-cell lines Guide to Techniques in Mouse Development, 19 93; 225:8 03- 8 23 87 Brook ... al Evidence for nuclear internalization of exogenous DNA into mammalian sperm cells Mol Reprod Dev 19 93; 34 (2): 133 - 139 50 Camaioni A, Russo MA, Odorisio T, et al Uptake of exogenous DNA by mammalian ... Res 1997; 233 (1):56-62 46 Sotolongo B, Lino E, Ward WS Ability of hamster spermatozoa to digest their own DNA Biol Reprod 20 03; 69(6):2029-2 035 47 Spadafora C Sperm cells and foreign DNA: a controversial...
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Tài liệu The Influence of Human Activity on the Environment ppt
... trees and pollutes rivers and lakes Acid rain causes erosion of buildings and statues particularly if they are made of limestone Deforestation • In may countries people are chopping down forests ... farmyard manure as a fertiliser and set aside land for growth of wild plants Biological Control of Pests • This means using natural predators to eat pests instead of pesticides • It does not have ... www.worldofteaching.com http://www.worldofteaching.com is home to over a thousand powerpoints submitted by teachers This is a completely free site and requires no registration Please visit and I...
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Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc
... Parenthood, among other criteria for exclusion .39 The rule was designed explicitly “to prohibit the participation of 33 Tex Hum Res Code § 32 .024(c-1) 42 U.S.C § 139 6a(a)( 23) 35 For example, Puerto Rico ... on-site referral 93% 7% 87% 7% 87% 87% 7% 7% 93% 47% 20% 87% 33 % 93% 80% 20% 73% 0% 7% 13% 7% 7% 0% 0% 13% 7% 67% 100% 100% 20% 0% 0% 87% 93% 93% 13% 93% 87% 7% 0% 0% 80% 0% 7% PPFA affiliates Total ... 5,9 53 5,808 63 92 102% Bexar County 10,176 5,718 51 112 178% Dallas County 21 531 % Hidalgo 5,779 1,074 51 County 55 250% Lubbock 2 ,34 2 936 17 County 42 537 % Midland 892 166 County 53, 4 73 65, 830 ...
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Tài liệu Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals pdf
... Hungary EU The Netherlands Sweden United Kingdom France Czech Republic Luxembourg Slovenia Austria Germany Denmark Incidence 1 .3 2.0 2.0 2.0 3. 0 3. 1 3. 2 3. 3 3. 3 3. 6 3. 7 4.2 4.6 4.8 5 .3 5.5 5.7 5.9 6.1 ... decline APMIS 109: 33 3 -34 4 Kaijser M, Akre O, Cnattingius S, Ekbom A 20 03 Maternal lung cancer and testicular cancer risk in the offrspring Cancer Epidemiol Biomarkers Prev 12: 6 43- 646 Kaleva M, ... Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol Journal of andrology 22 :32 3 -33 8 Main KM,...
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Tài liệu Evaluation of physical activity programmes for elderly people - a descriptive study using the EFQM’ criteria ppt
... mentioned assessments of the quality of the service delivered and 42 ,31 % of the coordinators reported that the organization has measures and/ or indicators of the financial results of the PA programme ... activities [31 -33 ] and involves a process of social influence on a group of people Our data suggests that the coordinators are particularly involved in developing the vision and mission, and enhance ... such as content of the planning and evaluation of PA programmes [ 13, 53] and health promotion programmes [54] Still regarding this criterion, most of the leaders of our study reported that everybody...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... metabolism and Lewy body disease 21 22 23 24 25 26 27 28 29 30 31 32 33 kinase-associated neurodegeneration, localizes to mitochondria Hum Mol Genet 12, 32 1 32 7 Hannun YA & Obeid LM (2008) Principles of ... recently described that loss -of- function mutations in the predominantly neuronal P-type ATPase gene ATP13A2 are the cause of Kufor–Rakeb syndrome [33 ] The clinical features of Kufor–Rakeb syndrome ... dementia is caused by mutations in ATP13A2, 5772 J Bras et al 34 35 36 37 38 39 40 41 42 43 44 45 46 encoding a lysosomal type P-type ATPase Nat Genet 38 , 1184–1191 Najim al-Din AS, Wriekat A,...
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Tài liệu An Empirical Analysis of Political Activity in Hollywood pptx
... 0.04 (3. 46) 1.78 (4.76) 1.02 (2. 63) 1.47 (3. 84) Age2 (x 100) -0. 03 (4.11) -0.02 (2.61) -0. 03 (2.89) -1.58 (3. 96) -0.96 (2 .38 ) -1 .34 (3. 31) Asian -0.06 (0.50) 0.02 (0.18) -0. 03 (0.11) -4 .31 (0.68) ... (1 .33 ) 0. 73 (1.79) 0.58 (0.62) 0.95 (1.14) 0.40 (0.44) College grad 1.06 (2.91) 1.09 (3. 01) 1.05 (2.92) 0. 13 (0.19) -0.25 (0 .39 ) -0 .31 (0. 43) Jewish 0.17 (0 .38 ) 0.26 (0.59) 0.16 (0 .35 ) 1. 13 (1 .32 ) ... 5.92 15 .39 15.46 10.87 7.19 5.77 6 .31 5.92 Top 25 box office films 2. 83 2.92 3. 11 3. 92 Top 75 box office starring roles 4 .39 3. 78 Top 25 box office starring roles 1.66 1.95 Average box office...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... mechanism of hepatic microsomal N-oxide formation I Eect of carbon 435 2 P Hlavica (Eur J Biochem 271) 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 monoxide on the N-oxidation of N,N-dimethylaniline ... demonstrating 436 0 P Hlavica (Eur J Biochem 271) 30 7 30 8 30 9 31 0 31 1 31 2 31 3 31 4 31 5 31 6 31 7 31 8 that the iron(III) complex is extremely nucleophilic Inorg Chem 36 , 979984 Wertz, D.L., Sisemore, M.F., ... Implications for mechanism J Biol Chem 275, 33 554 33 561 299 Hayashi, T & Hisaeda, Y (2002) New functionalization of myoglobin by chemical modication of heme propionates Acc Chem Res 35 , 35 43 300 Matsuo,...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... reaction and decomposed via reactions and The rate of formation depends on the concentration of NAD and oxygen and it is clear that this should be somewhat higher during oscillations because of the ... [32 ], hydroxyl radical [33 ] and peroxynitrite [34 ] Increasing the concentration of 4-hydroxybenzoic acid also resulted in a decrease in the rate of enzyme inactivation However, when Fig Eect of ... for inactivation of the enzyme may come from measurement of the effect of the concentration of the aromatic cofactor responsible for the onset of oscillations Here we use the fact that melatonin...
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Tài liệu AMAZONIAN ACCESSIONS OF WILD HEVEA GERMPLASM - A POTENTIAL SOURCE OF DROUGHT TOLERANCE pptx
... abcd 35 6.67 ab 446.62 bcd 33 3 .33 abcd 35 7 .30 481.48 a cd MT 938 296.29 AC 650 33 1.16 bcd abcd AC 652 34 8.58 RRII 105 427.01 AC 728 39 4 .34 Mean abc abcd 37 6.19 Leaf thickness ( m) abc 1 23. 93 fg ... 117.90 1 23. 77 abc a 129. 83 104. 23 109. 43 abcd cdef 114. 43 a 127.70 ab 127.27 def bcde bcd 37 1.00 defg 35 2.20 ab cde defg 34 6.48 419. 53 a fg 31 1.90 def 35 5.18 fg 31 2. 93 abc 400.20 efg 1 13. 73 318.67 ... 24.29 abc 33 .51 abcd 101 .38 50. 43 58.08 104.27 114.52 fg 48 .31 Mesophyll tissue thickness ( m) ab abc cdef 98.18 abcd 31 .19 34 .59 33 .47 29.76 33 .40 32 .38 a abc cde abc abcd ef 26.04 31 .3 Transverse...
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The Health Benefits of Physical Activity for Girls and Women ppt
... Tables 129 129 129 131 133 133 135 137 137 138 138 138 139 139 139 139 140 140 140 140 141 141 142 147 156 156 156 157 158 158 159 159 159 160 161 161 161 162 162 169 172 172 172 1 73 174 176 177 177 ... health and well-being of girls and women Recognition of the complexity of the dimensions of well-being and the determinants of health has led to the development of a range of theoretical models and ... point for the development of a richer understanding of the links between physical activity and the health and well-being of girls and women A Project Purpose and Limitations The Health Benefits of...
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Mortgage Loan Fraud: An Update of Trends based Upon an Analysis of Suspicious Activity Reports doc
... 162,720 3, 515 35 . 03% 19.80% 2001 2 03, 538 4,696 25.08% 33 .60% 2002 2 73, 8 23 5 ,38 7 34 . 53% 14.71% 20 03 288 ,34 3 9, 539 5 .30 % 77.07% 2004 38 1,671 18 ,39 1 32 .37 % 92.80% 2005 522,655 25,989 36 .94% 41 .31 % 2006 ... $38 ,712 12 North Carolina 644 605 6.45% $32 , 234 36 Indiana 640 435 47. 13% $32 ,526 33 Pennsylvania 635 5 53 14. 83% $36 ,680 18 Missouri 605 487 24. 23% $32 ,705 31 Washington 584 480 21.67% $37 ,4 23 ... 31 2 32 .69% $29,108 47 67 51 31 .37 % $55,755 4 83 376 28.46% $32 ,30 4 35 2,265 1,770 27.97% $31 ,891 38 New Hampshire 61 48 27.08% $39 ,31 1 Montana 33 26 26.92% $30 ,688 42 Ohio 957 765 25.10% $33 ,33 8...
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Báo cáo khoa học: Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution ppt
... (°C) )1 .3 )1 .3 )2.8 +1.5 T407A E83K A13V, I457F 0.88 1.05 1.27 +5.6 +3. 1 +5.5 A13V, T407A A13V, E83K, I457F A13V, E83K 1.12 1.42 1.42 +10.1 +5.6 +6.7 A13V, E83K A13V, E83K, T407A A13V, E83K, T407A ... origin of the mutations to be estimated For example, AS4, composed of A13V, E83K and T451A, was analyzed to be a reassembly of S3 (harboring the A13V mutation), S2 (harboring the E83K mutation) and ... Fig 4) and is located close to Ala 13, which is very important for the stability of the enzyme in this study In addition, the structural rationale for the other stability (E83K and T407A) and activity...
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Báo cáo khoa học: Kinetic properties of catecholoxidase activity of tarantula hemocyanin pot
... Garcia-Carmona F (1997) Kinetic study of the suicide inactivation of Catecholoxidase activity of tarantula hemocyanin 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 latent polyphenoloxidase from ... Agaricus [ 53] ) 475 17 s)1 (dopamine, Agaricus [ 53] ) 107 s)1 (L-DOPA, Agaricus [ 53] ) 1070 s)1 (L-DOPA, Neurospora [54]) 25 s)1 (tyramine, Agaricus [ 53] ) 30 lM (Streptomyces [37 ]) 3. 4 0 .3 lM (Streptomyces ... 11.9 1 .3 and 47.7 5.2 lm for kojic acid and l-mimosine, respectively Inhibition by tyramine was one order of magnitude weaker, with a KI value of 278.2 30 .6 lm Fitting attempts revealed that...
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Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx
... ura3–52 leu2 3, 112 his3-D1 trp1–289 MAL2–8c SUC2 [pFL38-RAS2] S1278b; MATa ura3–52 his3:hisG leu2::hisG sut2:: S.pombe his5+ S1278b; MATa ura3–52 his3:hisG trp1::hisG S1278b; MATa ura3–52 his3:hisG ... MATa/a ura3–52/ura3–52 his3:hisG/his3::hisG trp1::hisG/trp1::hisG S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX S1278b; MATa/a ras2::kanMX/ras2::kanMX ura3–52/ura3–52 his3:hisG/his3:hisG ... 5.5) and shifted to fresh glucose medium (SC 2% glucose) at time point (j) YEp351 + pFL38; (d) YEp351 + pFL38RAS2; (h) YEp351-SUT2 + pFL38; (s) YEp351-SUT2 + pFL38RAS2 Experiments were performed...
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The Carbon and Global Warming Potential Impacts of Organic Farming: Does It Have a Significant Role in an Energy Constrained World? pptx
... levels of output Org < Conv Org > Conv 10 23 14 0 23 30% Organic 7 32 % more efficient Organic 53% more efficiency 23% 34 % Sustainability 2011, 34 2 2 .3. 3 Greenhouse The energy efficiency of organic ... t–1 GHG100 kg–1 & C sequestration 13% 13% 11% 4 33 % for 2 /3 org farms 7% for 1 /3 org farms Sustainability 2011, 33 7 On balance, comparison results were mixed for hogs (Table 4) Including carbon ... contribution of energy use to GWP was 807, 862, and 34 4 in NT, CT, and Org3, respectively The contribution of N2O flux to GWP was 30 3, 406, and 540 kg CO2e ha–1 y–1 in NT, CT and Org3, respectively...
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Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc
... Eox/rd (mV) Eox/sq (mV) Esq/rd (mV) %SQ Wild-type K75E E 139 K E301A FAD )32 5 )30 5 )32 6 )284 )265b )33 8 31 2 )34 1 )35 8a )400b )31 2 –298 )31 1 )210 ) 130 b 22 27 21 0.2 a Data from [4] b DDGsq-ox (kcalÆmol)1) ... [4,15], and only recently have we been able to achieve its measurement [16] The close proximity of K75, E 139 and E301 to the flavin ring and the reported characterizations of K75E, E 139 K and E301A ... to that of the wild-type According to Eqns (1,2), the values of EE 139 Kox/sq ¼ )34 1 mV and EE 139 Ksq/rd ¼ )31 1 mV were calculated (Table 1) Thus, the Eox/rd, Eox/sq and Esq/rd values obtained for...
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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
... options are often limited In 1991, a U.S General Accounting Office (GAO) study reported that up to 33 % of all anticancer drug prescriptions were written for off-label indications .38 By 2005, ... estimated that 50% to 75% of all uses of anticancer therapy were off-label .39 The compendia have an important role to play in providing information to clinicians regarding off-label indications for ... declared conflicts of interest 4 .3 Example of the Potential for Conflict of Interest in Compendia: DRUGDEX and Allegations of Conflict of Interest The specific issue of conflict of interest related...
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the impact of abc (activity based costing) on manufacturing firm performance in vietnam
... 100 WCM 13 WCM 4 1 13 WCM 0 13 WCM 0 13 WCM 13 13 WCM 12 13 WCM 0 13 % 69. 230 77 30 .769 23 100 % 30 .77 30 .77 7.692 7.692 15 .38 7.692 100 % 0 30 .769 23 15 .38 462 53. 84615 100 % 38 .46154 61. 538 46 0 100 ... Plant-level control variables 35 3. 5 Research methodology 36 3. 6 Data sources and sampling 37 3. 6.1 Sample selection 37 3. 6.2 Data collection method 37 3. 7 Limitation of research 38 Chapter IV ANALYSIS ... Manufacturing 23 3 .3. 2 Impact of World-class Manufacturing on Plant Performance 26 3. 3 .3 Impact of ABC on Plant Performance: A Mediation Mechanism 28 3. 4 Measurement of variables 30 3. 4.1 Dependent...
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