pth mrna interactions determine the regulation of pth gene expression by serum calcium and phosphate
IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANS-FACTORS REQUIRED FOR THE REGULATION OF RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION
... main example of euchromatin includes house keeping genes that need to be expressed all the time III Epigenetic regulation of genes Epigenetics is the study of heritable changes in gene expression ... in the melting of the DNA TFIIH has kinase and helicase activity The kinase activity of this factor is required for the phosphorylation of the C-terminus domain (CTD) of Pol II that consists of ... in the absence of histone acetylation This is mediated by the interaction of N-CoR and mSin3A, the components of HDAC complex, with the preinitiation complex, therefore interfering with 20 the...
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The regulation of TXNIP gene expression
... the right contains name, ID and chromosomal positions for each gene. †: ARRDC2, isoform 1 and 2; ‡: arrestin β2, isoform 1. All genes shown are human genes. The expression products of Txnip and ARRDC genes also shared high level of similarity (with highest similarity to ARRDC2‐4, Figure 5). All these proteins contain ... to the promoter of cyclin A gene, and down regulation of cyclin A leads to arrest of cells at G0/G1 phases (Han et al., 2003). Over expression of Txnip is able to induce the expression of p16, which inhibits cyclin‐dependent kinase ... While the major focus of the research community has been on the physiology of Txnip at the organism level, the study on how the gene encoding Txnip is expressed and induced by ...
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Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt
... Morphogenesis Protein-1, and Fibroblast Growth Factor (FGF)-7 Their expression was inhibited by rhOP-1 from 1.93- to 1.5fold Contrary, the expression of the FGF-R2 and receptors, and a and b ... One of the limitations of the study is that we examined gene expression profiles only at one time point, after 48-hours of culture Therefore, changes in early-response genes and lateresponse genes ... reported their differential expression and spatial distribution in the dog OA model One of the most surprising results was the finding that OP-1 inhibits expression of another member of the BMP...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... illustrated by the presence of HIF-1-binding sites in their promoter regions, the up -regulation by hypoxia and cobalt chloride, and the general correlative relationship between HIF-1α and the levels of ... HIF-1-binding sites in the promoter regions of MCP-1 and MCP-5 genes Hypoxia and CoCl2 up-regulate the expression of both HIF-1α and chemokines MCP-1 and MCP-5 in astrocytes The levels of AP-1: Activator ... maximize the benefit effects of the inflammation The evidence of HIF-1α-mediated up -regulation of MCP-1 and MCP-5 during hypoxia suggests that HIF-1 α may be a target for the regulation of inflammatory...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... normal and degenerate samples by the addition of IL-1Ra but unaffected by the application of anti-TNF-α These results suggest that IL-1β, rather than TNFα, may be more important in the regulation of ... significant upregulation of mRNA of MMP-3, -9 and -13 in both normal and degenerate NP cells (P = 0.05) (Figure 1b) The upregulation of MMP-9 gene expression was significantly greater in degenerate ... the effect of IL-β and TNF-α on MMP-13 gene upregulation in normal and degenerate NP cells Effect of tumour necrosis factor-alpha on matrix gene expression The basal gene expression for the collagen...
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Báo cáo y học: " “pp65 antigenemia and real time polymerase chain reaction (PCR) based-study to determine the prevalence of human cytomegalovirus (HCMV) in kidney donors and recipients with follow-up studies.”" pptx
... determine the rate of detection of HCMV among kidney donors and recipients by application of pp65 antigenemia and quantitative real - time PCR Investigations are still going on to determine the ... of them were positive for HCMV by pp65 antigenemia assay Of the seventy six donors, eleven (14.47%) of them were positive for HCMV by real time PCR while one (1.3%) of them was positive for the ... from the study The mean age of the recipients was 48.5 year and the female to male ratio was 2:3 The age range among recipient males was 23 to 56 and female was 23 to 59 The mean age of the donors...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... main bronchi The embryonic stage is marked by the formation of the lobular and segmental sections of the respiratory tree as columnarepithelium-lined tubes evident by the end of the fifth or ... in the thickness of the interstitium, thinning of the epithelium and separation of the terminal air units This stage also marks the terminal differentiation stages of alveolar ATI and ATII epithelial ... central to the regulation and expression of stress-response genes in the face of inflammatory and oxidative challenge [13,14,16– 19,27,54,55,58] Oxygen and redox regulation of HIF-1α and NF-κB...
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The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression
... cell cycle regulation The summation of the above observations and findings has led to the synthesis of a hypothetical model to explain the dual role of hTRIP-Br1 in the regulation of mammalian ... in the context of E2F-1/DP-1 regulation, co -expression of KRIP-1 with the TRIP-Br proteins further augments the co-activation of E2F-1/DP-1 by the TRIP-Br protein 26 These data suggest that the ... growth (in the cases of Rsc1 and Rsc2) 15 (1.2.2) The role of PHD zinc fingers and bromodomains in the regulation of eukaryotic gene transcription To date, the molecular function(s) of the PHD zinc...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation Loss of ... cytoplasm (Fig 1A, B,D) To determine whether the disruption of cell–cell adhesion by Decma influenced expression of the uPA gene, we examined change in uPA mRNA levels Northern blot analysis showed ... disruption of E-cadherin-dependent cell–cell-adhesion and the expression of uPA are causally involved in tumor progression, the understanding of these underlying intracellular events is of importance...
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Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
... investigated the effects of combined ET-1 and TGF-b1 stimulation and of prolonged stimulation with respect to ET-receptor subtype expression and the induction of CTGF and TGF-b1 transcripts Results Expression ... fibroblasts, however, TGF-b1 neither induced the synthesis of ET-1 [71] nor did ET-1 induce the synthesis of TGF-b1 The interplay between TGF-b1 and ET-1 therefore occurs within their partly common intracellular ... [47–49] and N-butanol [50–52] as specific inhibitors of PLD The inhibition of PC-PLC by D609 (Fig 5B) and inhibition of PLD by neomycin (Fig 5C) as well as by N-butanol (not shown) abolished the increase...
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báo cáo hóa học: " Review of “Healing the Herds: Disease, Livestock Economies, and the Globalization of Veterinary Medicine” edited by Karen Brown and Daniel Gilfoyle" doc
... technologies in general by colonial administrations as a means to exploit resources The crop, forestry, water, fisheries, and other sectors all employed the modern technologies of the day, and if so, ... to the veterinary focus of the book, this wellresearched chapter reinforces a general pattern of negative attitudes towards pastoralism by government When introducing the book, Karen Brown and ... pastoralism and often view these areas as problems to be solved by modernization and settlement To some extent, the anti-pastoralist statements of current African policy makers seem even more extreme and...
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Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study" pps
... on the Isle of Wight, U.K The Isle of Wight is an island (13 × 23 miles) just off the South Coast of England with a resident population of 130,000 The population is stable to the extent that the ... cooperation of the children and parents who participated in this study, and appreciate the hard work of Mrs Sharon Matthews and the David Hide Asthma and Allergy Research Centre team in collecting the ... (100.0) position 144) and rs1295685 at the 3’ UTR/exon position of the gene Each of these SNPs had a minor allele frequency ≥ 19% Using the Haploview program [26], three of the five single nucleotide...
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Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx
... synchrony The data should speak for themselves 7) The DNA distribution of cells should be narrow in the synchronized cells and these distributions should then reflect the movement of cells through the ... which goes down to 2N and back to 4N and never repeats the 8N In between the start and the end there is no systematic variation of cells through G1, S and G2 In summary, the work of Whitfield et al ... cells are all recombined together and analyzed These combined cells should not give a variable pattern of gene expression This controls for perturbation of the culture by the selection method 15)...
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Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
... cells, the transcriptional activity of the hepatocyte nuclear factor-1 (HNF-1) decreased, limiting expression of the albumin gene [38] Another example is brought about by the activation of ATF2 and ... reporting the influence of amino acid removal or addition on some transcription factors, either at the level of their activation (mainly by their ability to bind DNA) or at the level of their expression ... action on gene expression, revealing the existence of a large variety of target genes involved in major functions in the organism [15,82,83] Tables and and Fig illustrate both the diversity of the...
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Báo cáo y học: " Quantitative biomarker analysis of synovial gene expression by real-time PCR" potx
... MMP-1, and GAPDH using TaqMan chemistry and Q-PCR as described in Materials and methods Figure shows that the stimulated PBMC are a source of mRNA for the target genes of interest The expression of ... aliquot of PBMC was assayed for GAPDH on each day and either the raw C(t) was recorded or the amount was correlated to the standard curve generated on the same day The CV was then calculated for the ... of the target and housekeeping gene are identical [23] The limitations of the C(t) methods of Q-PCR led us to consider a set of standard curves by which the assay results could be quantified and...
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Báo cáo y học: " Large scale comparison of global gene expression patterns in human and mous" pot
... conserved The cross-species conservation of expression profiles of tissue-specific genes and housekeeping genes is the foundation for the similar landscapes of sample clustering between human and mouse ... between two samples when projected onto the principal components is determined by the covariance of their gene expression profiles, we believe the similarity of the Human Liver Liver Mouse Nervous ... similar global gene expression patterns, causing the samples to cluster together when they are projected to the top principal components When profiling the transcriptome of thousands of samples from...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... of the response curve is strongly affected by the two groups of parameters that determine the protein–protein interactions: the concentrations of the enzymes relative to the target protein, and ... bound to kinase or phosphatase; the respective concentrations of the target will be denoted by Xn,0, Xn,K and Xn,P, respectively They are determined by the rates of the reversible enzyme–target ... thermodynamic aspects of complex multisite phosphorylation on the one hand, and the specific and versatile regulation of protein activation required in signaling pathways on the other Results Mathematical...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... overexpression of IFI genes [10], and confirms the involvement of interferon in SLE Since the immune system is regulated by an elaborate network, interactions among the downregulated genes and the ... examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above results, TNF, IFN, and E2 were depicted by both downregulated and upregulated ... regulation on the immune response-related molecules in SLE On the other hand, although the expression of IFN was Gene expression profiles of peripheral blood mononuclear cells by TNF stimulation...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... overexpression of IFI genes [10], and confirms the involvement of interferon in SLE Since the immune system is regulated by an elaborate network, interactions among the downregulated genes and the ... examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above results, TNF, IFN, and E2 were depicted by both downregulated and upregulated ... regulation on the immune response-related molecules in SLE On the other hand, although the expression of IFN was Gene expression profiles of peripheral blood mononuclear cells by TNF stimulation...
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DEVELOPING, USING AND ANALYZING THE RESULTS OF INTERVIEWS TO DETERMINE THE FEELINGS OF FOREIGN TOURISTS ON THEIR VISIT TO VIET NAM
... Most of them seemed too closed, to be friendly and warmhearted, and welcome us They told us everything they did in Vietnam and they thought about Vietnam in their travels Therefore, they helped ... about Vietnam tourism, what they hope and what they see? Then, teachers and students may know clearly about the fact of tourism in Vietnam It will help students have the right acknowledge about ... In general, the greatest number of tourist who coming to Vietnam recently is North American tourists with 42% There are smaller percentages of European and Oceanian tourists They occupy 33% and...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25