mẫu phiếu điều tra học sinh tham khảo

Báo cáo y học: "Animal models of copper-associated liver disease" doc

... is transported to the liver [18], with lesser amounts entering the kidney [17] Copper transport in hepatocytes can be divided into three discernible but interrelated steps: copper uptake, intracellular ... of serum enzymes, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) [63], aspartate aminotransferase (AST), and γglutamyltransferase (GGT), as well as bilirubin levels, are increased ... An ultrastructural study of the kidney of normal, copper poisoned and thiomolybdate-treated sheep J Comp Pathol 1986, 96:593-612 Gooneratne SR, Howell JM and Gawthorne JM Intravenous administration...

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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt

Danh mục: Toán học

... Intra-articular IL-1b over-expression in the adult Col1IL1bXAT transgenic mouse results in joint pathology with behavioral changes (A) Intra-articular injection of FIV(gfp) in Col1IL1bXAT transgenic ... [26] To this end, APP/ PS1; Col1-IL1b XAT compound transgenic mice were generated on the C57/BL6 background strain by crossing Col1-IL1b XAT transgenic mice into the APP/PS1 (B6C3-Tg(APPswe, PSEN1dE9)85Dbo/J) ... (Ct) values were then transformed, using the functionexpression = (1+ e) Ct, in order to determine the relative differences in transcript expression Using this method, transcript levels for IL-1b,...

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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

Danh mục: Báo cáo khoa học

... sequence containing the ﬁrst putative transcription start site (Fig 2B) These analyses demonstrated that the majority of CB1 transcripts were synthesized from transcription start site 1, which is ... primary transcript present at a given time point reﬂects the amount of newly synthesized primary transcript Relative rates of transcription can therefore be inferred from quantiﬁcation of primary transcript ... amount of protein produced from the transgene Therefore, the length of the polyglutamine tract encoded by the human HD transgene or relative expression of the transgene affects the rate of HD progression...

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Báo cáo khoa học: Amyloid-b protoﬁbril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx

Danh mục: Báo cáo khoa học

... protoﬁbrils in transgenic mice compared to nontransgenic littermates (14.3 ± 2.3, n = 17, P < 0.05) No effect of genotype was found when swim speed of nontransgenic (20.6 ± 1.0 cmÆs)1, n = 20) and transgenic ... last day of training (see Fig S2), suggesting that spatial search strategies were used by most of the animals Four individuals (two 4-month-old nontransgenic mice, one 8-month-old transgenic mouse ... learners compared to nontransgenic mice, and required more time to ﬁnd Amyloid-b protoﬁbrils in transgenic mice the hidden platform By contrast, memory impairment could not be demonstrated in the probe...

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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf

Danh mục: Báo cáo khoa học

... [16,17] In HD transgenic mice, overexpression and nuclear translocation of the enzyme was demonstrated in discrete populations of brain neurones [18] It has been suggested that the nuclear translocation ... by a decrease in the creatine concentration in the transgene mice compared to the control (Table 4) Table Metabolite concentrations and CK activity in the transgenic mouse model of HD Data are ... concentrations of glucose, NAD+, NADH, ATP and ADP were applied The high (30 mgÆmL)1) protein concentration was estimated on the grounds that the concentrations of the prepared cytosolic extracts...

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Báo cáo y học: "Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson’s disease: a case report" ppsx

Danh mục: Báo cáo khoa học

... she was referred to the National Transplant Organization for evaluation It was decided that she was eligible for emergency liver transplantation and she was transferred abroad However, within ... alkaline phosphatase (normal range 35 to 104), 33 IU/L alanine aminotransferase (normal range to 40), 140 IU/L aspartate aminotransferase (normal range to 37), 27.79 mg/dL total serum bilirubin ... 4:256 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication...

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Báo cáo y học: "Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson’s disease: a case report" pdf

Danh mục: Báo cáo khoa học

... she was referred to the National Transplant Organization for evaluation It was decided that she was eligible for emergency liver transplantation and she was transferred abroad However, within ... alkaline phosphatase (normal range 35 to 104), 33 IU/L alanine aminotransferase (normal range to 40), 140 IU/L aspartate aminotransferase (normal range to 37), 27.79 mg/dL total serum bilirubin ... 4:256 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication...

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Báo cáo y học: " Accidental Jorge Lobo''''s disease in a worker dealing with Lacazia loboi infected mice: a case report" doc

Danh mục: Báo cáo khoa học

... http://www.jmedicalcasereports.com/content/3/1/67 developed lesions after accidental trauma with plant thorns or insect bites, yet others not recall trauma before the disease The transmission between humans, especially domiciliary ... acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright BioMedcentral Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp Page of (page ... disease months after handling a L loboi infected dolphin [10] In contrast, in a man who apparently acquired the infection after traveling to Venezuela, the lesion appeared two and a half years after...

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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression

Danh mục: Sinh học

... intravitreal administration of extracts inhibited the formation of neovascular tufts during oxygen-induced retinopathy in mice Thus, inhibition of phosphorylations of ERK 1/2 and Akt by extracts ... Inhibition of this enzyme leads to an increase in the intracellular concentration of sodium and then an increase in the intracellular concentration of calcium (Sanborn, 2007) The increased myocardial ... extracts, as well as anthocyanin and proanthocyanidin fractions, were not highly active or were inactive in QR induction, whereas the ethyl acetate extracts were potent QR inducers The concentrations...

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TIỂU LUẬN CHẨN ĐOÁN AUJESZKY’S DISEASE VIRUS (ADV) BẰNG KỸ THUẬT NUÔI CẤY TẾ BÀO

Danh mục: Sinh học

... Diamine Tetra Acetate), Heparin, Sodium Citrate, EDTA thường sử dụng gây ảnh hưởng đến tế bào máu • Cách lấy mẫu mô: lấy nửa phần mô có bệnh tích, nửa phần giáp bệnh tích Cách bảo quản mẫu: • Mẫu để ... (95,8%) mẫu dương tính dòng tế bào BT, 117 (99,2%) mẫu dương tính dòng tế bào PK15 18 • Trong 121 mẫu dương tính với SVA có 113 (93,4%) mẫu dương tính dòng tế bào BT, 121 (100%) mẫu dương ... bị mẫu Những mẫu vật sử dụng để chẩn đoán ADV bao gồm tủy sống, phổi, lách, gan, thận, hạch bạch huyết, niêm mạc họng, amidam lấy từ 13 heo nghi ngờ nhiễm ADV Lấy mẫu thí nghiệm heo • Mẫu...

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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx

Danh mục: Sức khỏe giới tính

... their products are often claimed as trademarks All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners ... that accumulation of undegraded substrate proteins disrupts intracellular processes leading to neurodegeneration in familial PD Interestingly, parkin mutations in transgenic mice not cause nigrostriatal ... in the SNc in PD it demonstrates an intensely stained central core with a lightly staining surrounding halo with the protein-binding dye eosin Electron microscopy demonstrates a core comprised...

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Tài liệu Parkinson’s Disease and Related Disorders docx

Danh mục: Sức khỏe giới tính

... double transgenic approach as described by Mayford et al (1996) We crossed mice transgenic for a CaMKII-tTA construct with mice transgenic for a BiTetO-LacZ-rGDNF construct The double transgenic ... 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism J Neurosci 20: 8559–8571 Rivlin M, Ritov Y, Heimer G, Bergman H, Bar-Gad I (2006) Local shufﬂing of spike trains boosts the accuracy of spike train ... ventral tegmental=prefrontal region, dopaminergic neurons demonstrate precise timing of their ﬁring patterns, especially with respect to expectation of reward (Schultz et al., 1997) In contrast,...

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Tài liệu Alzheimer’s Disease and Other Dementias doc

Danh mục: Sức khỏe giới tính

... intellectually was obvious Eventually he began to lose weight, took to bed, and developed contractures (permanent muscular contractions) He died at age 72 of pneumonia An exam of his brain after his death ... immunodeficiency syndrome (AIDS), drug and alcohol abuse, head trauma, and multiple sclerosis and other demyelinating diseases Head trauma and What Is Dementia? infections such as AIDS can cause ... as a response to feeling hot Problems with abstract thinking Patients with Alzheimer’s disease may lose the ability to understand addition and subtraction or even what numbers represent This makes...

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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

Danh mục: Báo cáo khoa học

... couple good dopamine transporter activity with a low activity of the vesicular monoamine transporter type 2, such that cytoplasmic dopamine concentration may be raised by the administration of exogenous ... run in triplicate Transient transfection and luciferase gene reporter assay b-Gal and a-syn cells (60% conﬂuent in six-well plates) were transfected with pNF-jB-Luc plasmid (Stratagene, Santa ... into the nucleus through RanGTP-dependent transport and activates the transcription of target genes by recruiting other factors such as the histone acetyltransferase RuvB-like (Tip49 ⁄ pontin) In...

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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

Danh mục: Báo cáo khoa học

... or CAA In contrast to the other intra-Ab mutations, it makes APP an inferior substrate for a-secretase and increases Ab levels [79,80] APP cleavage by b-secretase was favored in transgenic mice ... disease-modifying treatment strategy for AD, and it also illustrates the potential clinical value of transgenic mice Immunization would probably never have been pursued if APP transgenic mice had not ... BT (2005) Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy J Neurosci 25, 7278–7287 Calhoun ME, Wiederhold...

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Tài liệu Báo cáo khoa học: A facile method for expression and puriﬁcation of the Alzheimer’s disease-associated amyloid b-peptide pdf

Danh mục: Báo cáo khoa học

... then extracted in M urea (fraction labeled U), and puriﬁed by ion exchange (fraction labeled IE), ﬁltration through a 30 kDa molecular mass cut-off ﬁlter (fraction labeled 30) and concentration ... m)1Æcm)1) was used to estimate the concentration of Ab in solution In four separate puriﬁcation experiments, the concentration of Ab(M1–40) in the 30 kDa ﬁltrate was determined to be between 30 ... The average Ab(M1–40) concentration in the 30 kDa ﬁltrate of the peak fractions (eluting at 75–125 mm NaCl) was 40 lm, based on the absorbance at 275 nm This concentration is higher than required...

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx

Danh mục: Báo cáo khoa học

... Parkin substrates [70,71] and Parkin folding seems to be dependent on chaperones [72] It is therefore tempting to speculate that proteins such as Parkin, PINK1, DJ-1, Hsp90, TRAP1 or HtrA2 might ... the evidence that mutations in HtrA2 modulate PD risk was later questioned and continues to be an area of debate Sanchez et al effectively demonstrated that HtrA2 is not a PD risk-gene in an ... cross-talk of pathways Extracellular and intracellular cues activate universal cellsignalling cascades including MAPK and phosphatidylinositol 3-kinase (PI3K) pathways that can target HtrA2, PINK1, Parkin...

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

Danh mục: Báo cáo khoa học

... ATP13A2 SNCA 9q22.1-22.3 1p36 4q21 LRRK2 12q12 Regulation of intracellular cholesterol trafﬁcking Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher’s ... present enlarged macrophages resulting from the intracellular accumulation of glucosylceramide These patients show increased levels of the enzyme’s substrate indicates that pathogenic variants act ... Interestingly, it has been recently demonstrated that PLA2G6 plays a role in the ceramide pathway; activation of this enzyme promotes ceramide generation via neutral sphingomyelinase-catalyzed hydrolysis...

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Tài liệu PARKINSON’S DISEASE pptx

Danh mục: Cao đẳng - Đại học

... brain’s neurotransmitters—especially dopamine—are so important to the central nervous system’s control of the muscles, when these neurotransmitters are lost, the muscles act strangely The central mechanism ... disease, as the concentrations of dopamine in the brain decline, so concentrations of other neurotransmitters such as norepinephrine and serotonin, although changes in these other neurotrans- WHAT IS ... administrative assistant skills during the preparation of this book We thank our editors at the Johns Hopkins University Press, Jacqueline Wehmueller, Alice Lium, and Linda Strange, who helped us transform...

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Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx

Danh mục: Sức khỏe trẻ em

... successful strains and future challenges Antonie Van Leeuwenhoek 1996;70:347–58 17 Goldin BR, Gorbach SL, Saxelin M, et al Survival of Lactobacillus species (strain GG) in human gastrointestinal tract ... to a Lactobacillus rhamnosus strain indistinguishable from L rhamnosus strain GG Clin Infect Dis 1999;28:1159–60 26 Salminen S, von Wright A, Morelli L, et al Demonstration of safety of probiotics: ... eosinophils); platelets 351,000/mm3; alanine aminotransferase level 1725 U/L; asparatate aminotransferase level 1185 U/L; alkaline phosphatase 353 U/L; gamma-glutamyl transpeptidase 199 U/L, total bilirubin...

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