... phenotype in tumors In addition, using proteins as markers of cell phenotypes, we showed that initiating oncogenes determine the developmental status of mammary tumor cells [8] Members of the Wnt ... described in the preceding section suggest that initiating oncogenes strongly influence gene expression in the tumors arising in these two Genome Biology 2005, 6:R84 information MMTV-Wnt-1-induced ... signaling [27] Consistent with these reports, we found higher level of Stra6 (P < 0.001, 9.0-fold) in MMTV-Wnt-1-induced tumors than in MMTV-Neu-induced tumors In addition, cellular retinol binding...
... severe inembryos injected with this morpholino Injection of all three lp125bMOs resulted in a comparable effect to that of m125bMO because this co-injection would inhibit the processing of all ... pmole morpholino induced a mild neural cell death in ~80% of injected embryos; and 0.75 pmole morpholino produced severe neural cell death in ~95% of the embryos m125bMO reduced the level of mature ... onset of apoptosis in miR-125b morphants: Embryos were injected with either misMO or m125bMO Cell death was observed in the brain by live imaging of the head and fluorescent imaging of fixed embryos...
... differentially during panicle developmentin rice in this study A very high level of expression of OsARF11, a putative ortholog of MONOPTEROS, during early panicle development, representing the stages of ... expression of downstream genes involved in auxin signaling The differential and overlapping expression patterns of individual members of these gene families in rice offer an amazingly vast regulatory potential ... stress conditions during various developmental stages In conclusion, the expression profiles of auxinresponsive genes during various stages of vegetative and reproductive developmentof rice suggest...
... under the control of the GAL10 promoter The induction of the yeast, by galactose containing media, results in overexpression of GAL4, in turn inducing an increase of the expression of the OR gene ... function of increasing amount of total proteins inmembrane fractions from I7 yeast strain induced at 15 °C, and from yeast expressing SSTR2 as a control activity By taking advantage of structural ... Plasma membrane trafficking of ORs in commonly cultured cell lines was slightly improved by appending N-terminal protein sequences from other seven transmembrane domain family members Fusion proteins...
... days Arthritis was induced on day by injection of 100µg of mBSA in 25 µl of saline solution into the right knee joint cavity R175 For clinical monitoringof AIA development, the joint diameters were ... analyses of the course ofof metalloproteinases (TIMP)-1, TIMP-3, cystatin B and anti-inflammatory Real-time polymerase chain in murine(PCR) joints duringtissue inhibitorantigen-induced arthritis interleukin ... marker of cartilage destruction The staining intensity of proteoglycans was very weak during the acute stage of AIA on days and 3, corresponding to the days of highest proteinase expression, in comparison...
... increase in a similar way in the control and in the treated group An increase in Raw can be associated to a reduction of airway calibre but, since in interstitial lung edema we did not find histological ... lifethreatening Competing interests The authors declare that they have no competing interests Authors' contributions RLD Contributed in the design of the study, in writing the manuscript, in the design ... Research 2008, 9:51 ing that the mechanical properties of the lung are affected during the developmentof interstitial edema and/or vascular congestion even when the increase of extravascular water...
... of these potential target genes have been functionally characterized My thesis work was initiated based on a bioinformatics screen looking for direct binding targets of AG In the first part of ... target genes of AGAMOUS……………………………….19 1.5 Functions of AT-hook DNA binding proteins duringdevelopment ………… …20 1.6 Objective of the study……………………………………………………………….23 1.7 Significance of this study………………………………………………………….23 ... target of AG in the regulation of reproductive organs patterning and differentiation in Arabidopsis thaliana through binding assay and expression analysis The GIK protein contains an AThook DNA binding...
... the onset of AG expression) 1.5 Functions of AT-hook DNA binding proteins duringdevelopment AT-hook DNA binding proteins may contribute to a functional nuclear architecture by binding to the ... for the expression of GIK following AG induction in developing flowers The transgenic line contains a gene coding for a fusion of the AG protein and the steroid binding domain of the rat glucocorticoid ... functional links of GIK to reproductive development from gain-offunction and loss -of- function studies Furthermore, I show that GIK is instrumental in coordinating regulation of multiple genes during...
... training Thus, continued participation in export markets requires continuous skill upgrading through training There is also increasing interest in the impact of global value chains on upgrading ... general education, official training and informal on-the-job training Informal on-thejob training is likely to correlate with the skill content of the job, and hence MNEs offer more of this when they ... training to work in international environment and to adapt easily with the frequency of technology changing Moreover, those institutes often supply the training program for local workers in international...
... components: Bac Linh Dam (North of Linh Dam), Linh Dam peninsula in the middle and Linh Dam expansion (South of Linh Dam) The success of the project has set the stage for a series of New Towns that ... climate Among these, the outstanding point is the area of highstorey apartments and office buildings in the center of Linh Dam peninsula, surrounding by low-storey buildings, parks, open spaces and ... Town (located in the south-west of Hanoi) deserves one of the new urban models, dealing with the high-density developmentin the south-west of Hanoi By learning from the planning of Linh Dam New...
... vật chất, tinh thần lao động nghèo nàn Họ thường tiêu tiết kiệm cho khoản chi phí sinh hoạt thiết yếu Có 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt thiếu thốn, vệ sinh Họ thường ... 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt không đảm bảo, vệ sinh; 40,95% không sử dụng nước có không ổn định; 11,43% cho chỗ họ an ninh không đảm bảo Có thể nói, nơi nữ lao động ... theo điều kiện sống mức tối thiểu, tạm bợ khu nhà trọ rẻ tiền với điều kiện sinh hoạt an ninh không đảm bảo Đời sống tinh thần lao động hạn chế Họ thấy cô đơn, nhớ gia đình Các hoạt động giao lưu,...
... involved in the binding of UDPGal and that E264 and W315 are involved in the GlcNAcbpNP binding site The residue E264, which is part of the conserved EDV motif, is involved in both substrate binding ... ferase toxin [32], using photoaf®nity labeling, the DXD motif has been implicated in the binding of UDP-Glc and Mn2+ It has been proposed that the DXD motif is involved in the folding of a small ... found in b1,3-GalTs and b1,3-N-acetylglucosaminyltransferases, thereby suggesting that they are more likely involved in mediating the b1,3-linkage speci®city rather than in the direct binding of...
... ordained with the aid of neighboring pastors In the matter of installation into a new office of an elder, previously ordained, churches are to exercise the right of individual judgment and of ... preliminary training of the men of the Puritan armies and of the Commonwealth, and for their great contest, all the years of Bible study, of controversial writing, of individual suffering, were ... England ministers was William Perkins, who was in discourse "strenuous, searching, and ultra-Calvinistic." He was a Cambridge man, filling the positions of Professor of Divinity, Master of Trinity,...
... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... “Shouldn’t we be individualizing drug dosing to attain sufficient inhibition in all patients?” Dr Small asked “This is something that hasn’t really been occurring in typical tyrosine kinase inhibitor ... National Institutes of Health, 2004 Suggested citation: IOM (Institute of Medicine) 2010 Policy issues in the developmentof personalized medicine in oncology: Workshop summary Washington, DC: The...
... Guiding Principles the first of their kind in the global mining and extractive industries Public Dissemination of Audit Findings Freeport and ICCA have also agreed on a process by which the findings ... shooting of members of the staff of the international school at Tembagapura since those shootings are being investigated by the U.S Federal Bureau of Investigation and by the Government of Indonesia ... training becomes essential PTFI has established a training institute, which shows promise of success These efforts must be reinforced and intensified In the long-run, the internal development of...
... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... “Shouldn’t we be individualizing drug dosing to attain sufficient inhibition in all patients?” Dr Small asked “This is something that hasn’t really been occurring in typical tyrosine kinase inhibitor ... National Institutes of Health, 2004 Suggested citation: IOM (Institute of Medicine) 2010 Policy issues in the developmentof personalized medicine in oncology: Workshop summary Washington, DC: The...
... 2009 Sustainable developmentin the plantation industry in Laos: an examination of the role of the Ministry of Planning and Investment Manitoba: International Institute for Sustainable Development ... 2008 Rethinking investments in natural resources: China’s emerging role in the Mekong Region Phnom Penh?: Heinrich Boll Stiftung Cambodia, WWF and International Institute for Sustainable Development ... promoted in the context of China’s ‘go out strategies’ The programme provides both financial and non-financial supports for Chinese investment in several sectors, including agribusiness, made in Myanmar...
... acquisition of literacy, including assessments and benchmarks, accommodating multiple levels of English proficient students in literacy instruction, and integrating subject matter into literacy instruction ... according to linguistic complexity Finally, instruction that focuses on forms integrated in meaning (FonF) capitalizes on brief interventions that, in meaningful communication, point out linguistic ... because of their developing English oral proficiency, and report on best practices in supporting English language developmentin the context of literacy instruction for these students Of primary interest...