modelling local circuit mechanisms for nicotine control of dopamine activity
Báo cáo y học: "Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome" pot
... informed our understanding of virus-host interactions important for virus replication These insights have also informed our understanding of specialized mechanisms that modulate translation of ... replication [76] A recent study of the 5' UTR of 16 env RNA isoforms produced by alternative splicing identified that production of Vpu is largely dependent on inclusion of exons that exclude the upstream ... results reinforced the important role of the upsteam AUG in tempering env translation initiation [78] Anderson and colleagues found that the four env mRNA isoforms containing exon 5E (isoforms 1,5,8,...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... IC50 values of 30 µM for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside ... notion of using SGLT inhibitors as a means to control circulating levels of glucose The selective inhibition of hSGLT2 by thioglycoside I, which is responsible for most of the reabsorption of glucose ... used to determine the amount of ATP in mg of protein measured from the number of cells per well After 24 h, the microtiter plate was taken for scintillation counting of radioactive [14C]AMG using...
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Development of DMC controllers for temperature control of a room deploying the displacement ventilation HVAC system
... to control the temperature of a building and have obtained impressive results The fuzzy control method of Zadeh [17] has also been widely used for control of many nonlinear systems; a fuzzy control ... band of temperatures for comfort The details of the geometry of the room and the HVAC system based on displacement ventilation for cooling the room are taken from Reference [1] The control of this ... International Journal of Energy and Environment (IJEE), Volume 4, Issue 3, 2013, pp.415-426 Output of the process Step input r(t) Performance of G1(z) -0.2 Performance of G2(z) Performance of G3(z) -0.6...
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The Potential of Biofumigants as Alternatives to Methyl Bromide for the Control of Pest Infestation in Grain and Dry Food Products
... make these means of insect control cheap and simple for users Lately, a new field has evolved which emphasizes the use of phytochemicals for insect pest management The bioactivity of essential oils ... distillation Three types of bioassays were performed to evaluate the activity of the fumigants The first screening of the compounds was space fumigation in glass chambers of 3.4-L capacity (for details see ... of all oils tested The main component of one of the oils is pulegone The other is not yet identified and it is called SEM76 (Shaaya and Kostyukovsky, 2006) In our study of the mode of action of...
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Alternative Processing Technologies for the Control of Spoilage Bacteria in Fruit Juices and Beverages
... 2001.6,7 CONTROL OF MICROBIAL CONTAMINATION Microbial contamination of fruit can occur at all stages of growth, harvesting, storage, and processing The surfaces of fresh fruits are often contaminated ... involves the use of mercury lamps, which generate 90% of their energy at a wavelength of 253.7 nanometers Exposure of bacteria to UV results in cross-linking of the thymine dimers of the DNA in ... strategy for microbial control and ensuring shelf life and safety of fruit juice and beverages 5–7 PASTEURIZATION16,31,32 Pasteurization of fruit and vegetable juice products has been applied for...
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Intrathecal baclofen for the control of spinal and supraspinal spasticity
... they sometimes ask for more local refill arrangements Often this cannot be implemented for lack of local skills and facilities two rates are usually sufficient, one for day and one for night When setting ... baclofen for treatment of children with spasticity of cerebral origin J Neurosurg, 87: 409–14 Azouvy, P., Mane, M., Thiebaut, J B et al (1996) Intrathecal baclofen administration for control of ... Intrathecal baclofen for the control of spinal and supraspinal spasticity The average ITB dose rate required is lower for the walking group than for the nonwalking group As for other patient...
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Tài liệu APICE: Common Mediterranean strategy and local practical Actions for the mitigation of Port, Industries and Cities Emissions pdf
... conference is one of most prominent forums for discussing the latest scientific developments, applications and implications for policy and other users An important feature of the conference is ... constitute a firm reference for any future study and/or development Number, emission profile (i.e the chemical composition of the pollutants emitted by a specific source) and impact of the major pollution ... and scientific meeting of the APICE project will be held in Venice on 24th 26th January 2012 During the meeting a full day will be devoted to the discussion of the results of the intercomparison...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... Travo for his help in ¯uorescence imaging and computerized analysis of pictures We are grateful to Dr Jean-Jacques Vasseur for performing MALDI-TOF analysis of peptides We also thank I Robbins for ... length of the polyarginine tract seems critical, as a maximal rate of internalization was observed for a peptide nine arginine residues in length The D-form and the retro-inverso form of the ... (Sigma) was performed as previously described [21] However for easier handling of the cells, treatment was performed on HeLa cells instead of CHO K1 cells Cells were then incubated with of lgámL)1...
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Tài liệu Một số thuốc mới chống rối loạn lipid máu (New drugs for the control of dyslipidemia) pdf
... ezetimibe với cholestyramin, cyclosporin Dùng riêng, rosuvastatin dễ dung nạp, kể phối hợp với fenofibrat, niacin, cholesteramin, dáng dấp an toàn tơng tự statin lu hành Chỉ định ezetimibe tăng ... thành mạch, vitamin E chống chọi với oxy hoá LDL chống tác hại gốc tự nội bào * Bình rợu cũ Fenofibrat (liphanthyl) từ lâu đợc dùng phổ biến để điều chỉnh nguy rối loạn lipid máu, fenfibrat có ... mạch vành có nguy Điều muốn trình bày thay đổi dạng bào chế làm tăng hiệu lực tăng độ an toàn fenofibrat lên rõ: - Dạng cũ liphanthyl standard (100mg 300mg) 125 TCNCYH 28 (2) - 2004 - Dạng cải...
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Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release docx
... to account for the repression of COX-2 or COX/PGES activity, as the EC50 for this effect is greater than 10-fold more than that required for the inhibition of PGE2 release or COX/PGES activity ... action for RU486 at the level of arachidonic acid release We therefore conclude that these data document the existence of at least two functionally distinct processes for the inhibition of inflammatory ... different mechanisms of stimulation were used in each of the studies, and this alone could account for any differences Furthermore, inspection of our current data on the repression of both PGE2...
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Báo cáo hóa học: " Influence of the training set on the accuracy of surface EMG classification in dynamic contractions for the control of multifunction prostheses" potx
... separated, without the analysis of performance of an approach of classification of both types of signals concurrently Therefore, this study investigates the performance of several pattern recognition ... has been shown to be one of the best classifiers for myoelectric control under stationary conditions [10] The SVM offers a more complex approach Depending of the choices of the kernel and parameters, ... for the subject i using the training section with a length of x (T is for Threshold-based) We then normalize the error for each training section with respect to the overall index of ability for...
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báo cáo hóa học:" The intra-articular use of ropivacaine for the control of post knee arthroscopy pain" doc
... Figure The comparison of VAS values of the groups at 1,2,3 hours The comparison of VAS values of the groups at 1,2,3 hours Page of (page number not for citation purposes) Journal of Orthopaedic Surgery ... nausea and headache for the first hours Visual Analogue Score (VAS) for pain scores was recorded at intervals of 1, 2, 3, and h after the intra-articular injection In case of need of supplementary ... Discussion Many modes of postoperative analgesia have been reported for patients undergoing knee arthroscopy [8] The use of opioid drugs, administered by means of either patient-controlled analgesia...
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electromechanical dampers for vibration control of structures and rotors
... variation of the reluctance of the magnetic circuit produces a time variation of the magnetic flux The flux variation induces a current in the voltage driven coil and, therefore, a dissipation of energy ... better understanding of the application of the electromagnetic theory to control the vibration of machines and mechanical structures According to the theory basis, the modelling of the damping devices ... damping efforts can be classified in two main categories: Maxwell devices and Lorentz devices For the first, the force is generated due to the variation of the reluctance of the magnetic circuit...
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Báo cáo lâm nghiệp: "Whole tree hydraulic conductance and water loss regulation in Quercus during drought: evidence for stomatal control of embolism?" doc
... unchanged for the control tree and that the maximum flow densities were comparable for the different days The maximum transpiration rate was therefore not limited by climatic conditions for these ... revealed the role of specific hormones (ABA) in the control of g during drought Roots in s the dry zones of the soil are producing ABA that provoke stomatal closure An argument in favor of hormonal ... computed that for the driest trees, the dif- ference between dF and dF cavitation midday represented less that a few percent of the midday dF of the control trees It can be noted that for some droughted...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
... calculated on the basis of the rate of accumulation of joint damage over a specific interval of time, and therefore an effect of I50V on severity may have been overlooked The pattern of IL-17 suppression ... IL-4R, did not control RA severity These findings suggest that a unique IL-4R polymorphism may predict disease outcome in RA Since tight control of the clinical activity of Page of RA substantially ... and control groups Two years after the onset of disease 68% of RA patients homozygous for the V50 allele had radiographically visible bone erosion compared to 37% of the patients homozygous for...
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Báo cáo y học: "A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906" potx
... were used for batch-to-batch comparisons Of the 39 peaks of the chemical fingerprint of PHY906 (S) accounted for 25 of 39 peaks, (P) accounted for of 39 peaks, (G) accounted for 10 of 39 peaks ... and biological profile of the extract for the purposes of quality control composition or the biological response of the herbal extract While the current standards for quality controls utilizes ... coded for proteins with a variety of cellular functions No information regarding cellular mechanisms of action of PHY906 could be inferred from these data, as the data indicated the cellular bioactivity...
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APPLICATION OF TUNED MASS DAMPER FOR VIBRATION CONTROL OF FRAME STRUCTURES UNDER SEISMIC EXCITATIONS
... APPLICATION OF TUNED MASS DAMPER FOR VIBRATION CONTROL OF FRAME STRUCTURES UNDER SEISMIC EXCITATIONS A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF TECHNOLOGY ... “APPLICATION OF TUNED MASS DAMPER FOR VIBRATION CONTROL OF FRAME STRUCTURES UNDER SEISMIC EXCITATIONS” submitted by Rashmi Mishra in partial fulfillment of the requirements for the award of Master of Technology ... 30-32 3.3 Equation for forced vibration analysis of multi-storey plane frame 32-37 3.4 Forced Vibration analysis of TMD-Structure interaction problem 37-39 3.4.1 Solution of Forced vibration problem...
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Epigenetic control of neuronal activity dependent gene transcription as a basis for long term memory formation
... to the love of my life, Christine Chan, PhD candidate, for correcting my drawings of neurons that look like “Strepsils™”, for those many hours of rehearsals before presentations, and for helping ... B Classifications of memory II Molecular Mechanisms of Long-Term Memory Formation A Overview: plasticity and activity B Epigenetics as a mechanism of activity- dependent gene ... approaches in formulating theories about learning and memory, studies of direct removal of certain areas of the brain such as in the case of H.M2 definitively show that the underlying mechanisms of memory...
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Pharmacokinetic and pharmacodynamic mechanisms for reduced toxicity of CPT 11 by thalidomide and st johns wort
... 1.2.3 1.3 Anti-tumor activity and mechanism of action of CPT-115 Toxicities of CPT-11 .14 THALIDOMIDE .19 1.3.1 Clinical activity and mechanism of action of thalidomide ... lactone form has been found to be essential for the stabilization of the DNA-Topo I complex and the tumor inhibitory activity of the lactone form is significantly greater than the carboxylate form ... Inhibition of biliary excretion of CPT-11 All agents of this type are capable of interfering with the metabolism of CPT-11 and SN-38, to reduce the intestinal level of toxic SN-38 and increased formation...
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