mean net charge of intrinsically disordered proteins experimental determination of protein valence by electrophoretic mobilit
Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
... highly disordered proteins with the highly ordered proteins, an increase of 23.5% is observed instead of 42.5%, and comparing the disordered proteins with the ordered proteins, an increase of 4.4% ... accumulation of disordered proteins and their transcripts in the cell Unexpectedly, for a proportion of highly disordered proteins, all four of these trends were reversed The highly disordered proteins ... and protein levels for a high proportion of these disordered proteins compared to the ordered proteins On the other hand, it is shown that for a significant proportion of highly disordered proteins, ...
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Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt
... IFN-induced changes in the levels of TRAIL receptor proteins or the large or Control of protein synthesis by IFNa and TRAIL small forms of the caspase-8 antagonist protein c-FLIP (I W Jeffrey, unpublished ... Effects of IFNa treatment on the sensitivity of cells to inhibition of protein synthesis by TRAIL We have previously shown that protein synthesis is rapidly downregulated following exposure of cells ... extent of phosphorylation of 4E-BP1, as revealed by a shift in the migration of the latter protein on SDS gels from the b and c forms to the hypophosphorylated a form (Fig 3C,D) and by the loss of...
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Báo cáo khoa học: Structural determinants of protein stabilization by solutes The importance of the hairpin loop in rubredoxins pdf
... stability on proteins: an induced overall compaction of the native protein, and specific, weak interactions of the solutes with the protein surface Experimental procedures Mutagenesis of Rd and protein ... that of the parent Rd, whereas mutant D23|29 shows a decrease of two positive charges and mutant D17|29 has a net loss of one positive charge In the case of mutant D23|29, which is destabilized by ... the positive contribution of this hairpin structure to the stability of this family of proteins In apparent contrast, the shortening of loops observed in thermophilic proteins compared with mesophilic...
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Báo cáo khoa học: The thermodynamic analysis of protein stabilization by sucrose and glycerol against pressure-induced unfolding The typical example of the 33-kDa protein from spinach photosystem II docx
... on a larger set of globular proteins are required to determine the validity of each of the possible explanations [31] The contraction of the protein solvent interface caused by the increase in ... The kinetic basis for the stabilization of staphylococcal nuclease by xylose Protein Sci 6, 789– 793 19 Xu, Q & Briker, T.M (1992) Structural organization of proteins on the oxidizing side of photosystem ... mLÆmol)1 which might be the DV minimum of the protein (or of the system: protein, solvent and sucrose) in the presence of sucrose From this value, the P1/2 of the protein was estimated to be % 400...
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Báo cáo y học: "Creation and disruption of protein features by alternative splicing a novel mechanism to modulate function" docx
... localization of a protein by alternative splicing Assuming a protein feature is encoded in two parts by two non-consecutive exons, for example, exon and 4, inclusion of exon results in a protein lacking ... the inclusion of two exons resulted in a loss of one TM domain as well as the gain of three others (Figure 1b) The massive reconstruction of TM domains in the respective protein isoforms can have ... encoded by two exons) TM domains that are To find by two tion, we applied the procedure to experimentally verified post-translational modification sites Post-translational modification of proteins...
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Báo cáo y học: "Evolution of protein complexes by duplication of homomeric interactions" ppt
... x = 340 proteins, representing the total number of 241 protein families and 29% of unassigned proteins in the Yeast dataset We randomly introduced an interaction between any pair of proteins ... previously that duplication of protein interactions and of entire protein complexes is accompanied by specialization of function [9] Inspection of the effects of duplication of homo-interactions suggests ... of these self-interacting proteins Our study provides the first insight into the evolution of functional modularity in protein- protein interaction networks, and the origins of a large class of...
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IDENTIFICATION OF INTRINSICALLY DISORDERED SEPTAL PORE ASSOCIATED PROTEINS REGULATING DIVERSE ASPECTS OF
... for SPA proteins are as follows: (i) mean hydrophobicity, (ii) net charge, (iii) magnitude of net charge, (iv) composition of arginine, (v) mean net charge, (vi) magnitude of mean net charge, ... found in other intrinsically disordered proteins (IDPs) such as FG-repeat nucleoporins (FG-Nups) and SR-repeat splicing factors (SR -proteins) SPA proteins possess a low mean net charge, which ... IDENTIFICATION OF SEPTAL PORE ASSOCIATED PROTEINS 4.1 Results 4.1.1 Mass Spectrometry Identification of SPA proteins .51 4.1.2 Machine Learning Identifies the SPA Family of Intrinsically Disordered Proteins...
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... disordered protein domains Compactness of fusion proteins depends on the disordered moiety In further experiments, we investigated the effect of the disordered domain on the electrophoretic mobility ... measured mean ellipticity values per residue of proteins and 2, respectively, 4448 and n1 and n2 correspond to the number of residues of proteins and When recording spectra of equimolar (4 lm each) protein ... spectra The CD spectrum of each of the fusion proteins is compared with that of individual proteins, with the theoretical average spectrum and with the spectrum of equimolar protein mixtures (A)...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... paper by Iakoucheva et al [22] that demonstrated that proteins associated with cancer (79% of proteins) and proteins associated with signal transduction (66% of proteins) are more highly disordered ... extremely disordered proteins Thus X-ray studies of extremely disordered proteins tend either to focus on the ordered domains of the proteins that can be readily crystallized, or are studies of protein ... likely to be disordered than non-nuclear proteins It is interesting to note that 50% of the proteins annotated in SWISS-PROT as autoantigens are nuclear proteins but only 21% of human proteins are...
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Báo cáo y học: "Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins" pdf
... level of intact genes and proteins Intrinsically disordered protein regions have a higher proportion of fixed non-synonymous polymorphisms Having observed that intrinsically disordered protein ... regions encoding intrinsically disordered regions of proteins (a) The ratio of positive to negative sites is higher in IDRs than in regions of regular protein structure The ratio of positive to ... the context of the structure, function and evolvability of proteins Results The frequency of codon sites under positive selection is enhanced in protein regions with intrinsically disordered structure...
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Identification of Publications on Disordered Proteins from PubMed
... shot of final output 36 vii LIST OF ABBREVIATIONS IDP Intrinsically Disordered Protein IDPs Intrinsically Disordered Proteins IDR Intrinsically Disordered Region IDRs Intrinsically Disordered ... 30% of eukaryotic proteins are mostly disordered [3], that more than half of eukaryotic proteins have long regions of disorder [3, 4], and that more than 70% of signaling proteins have long disordered ... or property of a disordered proteins To benefit from the advantages of the frequently occurring words occurring in the context of describing disordered proteins, we compiled a list of keywords...
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Performance enhancement of solar module by cooling: An experimental investigation
... maximum power of the module, specific to the module rating and thickness The experimental results suggest a way to improve the performance of the module by cooling of the solar modules by silicone ... improvement in the parameters of keen interest But, there has been a variation of the parameters over a range of values, for different thickness The tradeoff between the amount of light absorbed (least ... Examination for Energy Auditors held in 2006,conducted on behalf of The Bureau of Energy Efficiency, Ministry of Power, Government of India by National Productivity Council, Chennai ISSN 2076-2895 (Print),...
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MEAN TEENS- Prevention of social aggression at school
... positive way of dealing with the situation: Creating a Peaceful School Name: MEAN TEENS” MEANTEENS Date: _ Worksheet for comics What you think the point of this comic ... Name: MEAN TEENS” MEANTEENS Date: _ Worksheet for comics What you think the point of this comic is? Give this comic a title What is mean about this comic? Make up ... comics MEAN TEENS” What you think the point of this comic is? Give this comic a title What is mean about this comic? Make up your own comic showing more social bullying or show a positive way of...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... 1A1 proteins were localized inside of the inner membrane Moreover, the imported + ⁄ 1A1 and + 33 ⁄ 1A1 proteins were extractable with alkaline Na2CO3 as shown in Fig 2C, suggesting that both proteins ... pathway is required for targeting of a subset of precursor proteins to mitochondria It is likely that PKA phosphorylation is a more general pathway for the targeting of proteins lacking the canonical ... targeting of rat CYPs in yeast cells 2B 1/B Y4 74 2B 1/p ep 4Δ ' N B V Sepuri et al 25 16 Fig The levels of expression of CYP1A1, CYP2B1 and CYP2E1 proteins in yeast cells Yeast strains BY4 741 or...
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The 2000-2005 World Outlook for Program Administration and Net Cost of Private Health Insurance pdf
... 2000, www.icongroupedition.com 2.27 LIBYA Program administration and net cost of private health insurance (US $ mln): Libya 1995 - 2005 Year Libya % of Region % of Globe 1995 1996 1997 1998 1999 ... and Net Cost of Private Health Insurance 34 2.38 REPUBLIC OF CONGO Program administration and net cost of private health insurance (US $ mln): Republic of Congo 1995 - 2005 Year Republic of Congo ... Net Cost of Private Health Insurance 2.6 18 BURKINA FASO Program administration and net cost of private health insurance (US $ mln): Burkina Faso 1995 - 2005 Year Burkina Faso % of Region % of...
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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx
... Components of this pathway include several proteins, including the Gi class of G proteins, GoLoco domain-containing proteins i.e mammalian N-terminal Leu–Gly–Asn repeats (LGN) and activator of G protein ... Promotion of MT assembly by Gβγ GTP-Tubulin γ-Tub Fig Model for the regulation of microtubule (MT) assembly by a and bc subunits of G proteins Based on in vitro results using purified tubulin and G protein ... III AGS proteins (AGS2-10) appear to regulate heterotrimeric G protein signaling by a mechanism independent of nucleotide exchange In contrast to group I and II AGS proteins, each member of the...
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take charge of your workers' compensation claim
... notice of the / 12 TAKE CHARGE OF YOUR WORKERS’ COMPENSATION CLAIM termination or layoff and your medical records contain evidence of the injury prior to the notice of termination or layoff Injuries ... exception • The date of injury is after the date of notice of termination or layoff, but prior to its effective date If, for example, you receive notice that you’ll be laid off at the end of the month, ... held the first Tuesday of every month at every district office These free one-hour workshops consist of a presentation by an Information and Assistance officer followed by a question and answer...
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Báo cáo hóa học: " Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses" pot
... purposes, they consisted of empty "core" particles generated by the sole expression of MLV Gag proteins [20], whereas for infectious assays, they comprised MLV GagPol proteins and a recombinant ... incorporation levels of the different proteins were determined by Western Blot analysis using polyclonal sera against H7N1-HA, H5N3-HA, H7N1-NA and M2 proteins HA0: HA precursor protein, HA1: HA ... quantities of MLV Gag-derived capsid (CA) proteins (Fig 1A) This was most likely due to a less effective release of VLPs into the cell supernatant in the absence of NA Indeed treatment of these...
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báo cáo hóa học:" The net cost of incorporating resistance testing into HIV/AIDS treatment in South Africa: a Markov model with primary data" pot
... series of one-way sensitivity analyses for the three main cost inputs to the model: the cost of a year of first-line treatment; the cost of a year of second-line treatment; and the cost of a resistance ... parameters The cost of the LT strategy is nearly identical to that of the RM strategy if the cost of second-line therapy falls or the cost of a resistance test increases, however The ranking of the full ... GHS-A-00-03-00020 and by Award K01AI083097 from the National Institute of Allergy and Infectious Diseases of the U.S National Institutes of Health We thank Carole Wallis for analysis of the resistance...
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Báo cáo toán học: " Sharp bounds for Seiffert mean in terms of root mean square" pot
... )/2]1/2 are the Seiffert mean and root mean square of a and b, respectively 2010 Mathematics Subject Classification: 26E60 Keywords: Seiffert mean; root mean square; power mean; inequality Introduction ... bounds of rootsquare and harmonic root-square means for Seiffert mean Int J Math Anal 5(39), 1897–1904 (2011) [10] Pillichshammer, F: On the root mean square weighted L2 discrepancy of scrambled nets ... Seiffert mean T (a, b) and root mean square S(a, b) are defined by T (a, b) = a−b a−b arctan( a+b ) (1.1) and a + b2 , S(a, b) = (1.2) respectively Recently, both mean values have been the subject of...
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