mapks extracellular signal regulated kinase erk signaling pathway to the effect of amelogenin on the proliferation of mscs
Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... enhances activation of eosinophils in EoE specifically Page of The increased global expression of bFGF led to the investigation of the local expression bFGF of the esophageal biopsies of the subjects ... Figure a There is a positive correlation between the fold expression of bFGF and ERK, suggesting that the upregulation of bFGF may also influence the upregulation of ERK Figure 2b: There is a ... However, there was no analysis of FGF expression in plasma or peripheral blood mononuclear cells There was no evaluation of other FGF isoforms [23] Moreover, a possible link to the mechanism of EoE...
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Báo cáo Y học: CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK) doc
... responsible for its multiple roles in the proliferation and differentiation of chondrocytes, and analyzed the relationship between the MAPK pathways and the proliferation and differentiation of ... different phosphorylation of MAP kinase Effects of MAP kinase inhibitors on DNA synthesis in HCS-2/8 and RGC cells To investigate the signal pathways for proliferation of chondrocytes induced by CTGF/Hcs24, ... bar 4) These findings suggest that the p38 MAPK pathway is the most important signalling pathway in the differentiation of chondrocytes The ERK pathway does not seem to be involved in the differentiation...
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Tài liệu Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling pptx
... binding of nuclear extracts to the AP-1 site at )92 ⁄ )86 is reversed by catalase and by specific inhibition of ERK1 ,2 signaling To further substantiate the role of ROS and of ERK1 ,2 signaling ... downregulation of Rho is not likely to be involved Tiam1 ⁄ Rac-induced upregulation of TIMP-1 is reversed by specific inhibitors of ROS and ERK1 ,2 signaling pathways To analyze the roles of ERK1 ,2 ... as n-fold activation of the TIMP-1 promoter construct in comparison to the effects of empty vectors Ca-JNK failed to activate the TIMP-1 promoter, and dn-JNK failed to inhibit the C1199-Tiam1-induced...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... However, the mechanism underlying the transcriptional activation of BimEL downstream of ERK activation is not known The aim of this study was to identify the ERK- responsive transcription factor that ... designed to examine the mechanism of hepatocyte apoptosis, with a particular focus on identifying the transcription factor(s) that activate BimEL transcription downstream of the ERK pathway We cloned ... upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress...
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Báo cáo khoa học: Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase⁄Akt pathways pot
... activation of ERK1 ⁄ in mesenchymal chondroprogenitor N1511 cells but has no effect on activation of JNK and p38 MAPK Next, we investigated the effects of MAPK inhibitors on the proliferation of cartducin-stimulated ... MAPK pathways not seem to be involved in the cartducin-stimulated proliferation of these cells Another signaling pathway associated with the control of cell proliferation is the PI3K ⁄ Akt pathway ... required for the progression of mitosis, promoting the entry of quiescent cells into the S phase, and the downstream phosphorylation of Akt is in part responsible for the propagation of this signal...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... bikunin on the expression of other proteins regulated through PKC and ERK could give information on whether bikunin has ubiquitous effects on protein expression We found that the effects of bikunin ... with the uPAR signal to ERK activation, mimic the in vivo dormancy induced by downregulation of uPAR With these in mind, we investigated the regulation by bikunin of ERK activation as a signaling ... ascribed to activation of the classical pathway (Ras fi c-Raf1 fi ERK signaling cascade) [51] An alternative pathway consists of the sequential activation of Rac1, MEKK1, c-Jun N-terminal kinase kinase...
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Báo cáo y học: "Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes" docx
... independent of the Smad signaling pathway Our data support the strong contribution of Ank to the pathogenesis of sporadic chondrocalcinosis, in addition to familial chondrocalcinosis, and identify signaling ... we failed to demonstrate any contribution of PKA to the induction of Ank by TGF-β1 (TGF-β1)-induced responses in on transforming Effect of Smad overexpressionrat chondrocytes growth factor-beta-1 ... [35,36] Furthermore, we demonstrated that the activation of ERK 1/2 by TGF-β1 was strongly dependent on the activation of Ras In chondrocytes, the production of ePPi was also reported to be stimulated...
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Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla pps
... regard, the extracellular signal- regulated kinases (ERKs) present themselves as another reasonable candidate for the prolife program As a member of the mitogen-activated protein kinases (MAPKs) , ERK1 /2 ... according to the manufacturer’s protocol of a commercial kit (Cell Signaling, Danvers, MA, USA) to detect the levels of ERK1 /2 or phosphorylated ERK1 /2 at Thr202/Tyr204 The final absorbance of reaction ... apoptotic signaling pathway in sympathetic neurons J Biol Chem 2000, 275:8817-8824 Schonhoff CM, Bulseco DA, Brancho DM, Parada LF, Ross AH: The Ras -ERK pathway is required for the induction of...
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Báo cáo y học: "Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment" pptx
... Differences in signaling pathway activation of mechanical ventilation with bleomycin The serine/threonine kinase/ protein kinase B (Akt) and extracellular signal- regulated kinase (ERK) 1/2 pathways ... to be careful in differentiating the effects of inhibitors and genetic mutation on the inflammatory pathways versus the fibrogeneic pathways Two methods were employed to differentiate these effects ... phosphorylation of the Akt and ERK1 /2 pathways Using Akt-deficient mice and an ERK1 /2 inhibitor, we found a decrease of lung fibrosis – suggesting the involvement of Akt and ERK1 /2 in the regulation of...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... further confirmed by the observation that, differently from the effect of serum, the stimulatory effect of PMA on ERK1 /2 activity could also be totally abolished by NAMI-A Within this context, the ... shown in the panel B ECV304 cells and that such a condition plays a key role in the alteration of the growth behavior of these cells [24] Constitutively active components of the ERK pathway have ... (1999) The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation Endocrinology...
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Báo cáo khoa học: Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport ppt
... applied up to 24 h before cadmium (Fig 3B, ‘)24’), ERK activation was also stronger than in the absence of the inhibitor, whereas the addition of the inhibitor h after cadmium treatment no longer ... sustained ERK activation, we wanted to determine the effect of GF 109203X on the morphology of cells exposed to cadmium This is illustrated in Fig 4A, where the phenotypic response of cells to cadmium ... sustained ERK activation and consequently affecting cell response to cadmium poisoning Discussion Investigation of the molecular basis of cadmium toxicity during the last decade has resulted in the...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... stimulation with EGF and PMA together on the one hand, and the sum of the ERK- PP concentrations after stimulation with EGF and PMA separately on the other hand, was not constant, but increased with the ... synergistic effect EGF concentration-dependency of synergistic activation To investigate the synergistic activation in the second phase of the time profile further, we measured the ERK- PP concentration ... the EGF signal to ERK, also increases the EGF concentration that is needed for half-maximum ERK phosphorylation (Fig 3) Clearly, control of PKCmediated EGFR phosphorylation on signalling to ERK...
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Báo cáo khoa học: Identification of mitogen-activated protein⁄extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large docx
... functions [2] The outcomes of ERK activation are as various as the ERK substrates, and so an accurate regulation of the ERK signaling pathway is necessary This pathway is under the control of different ... localization and the duration of the signal For example, the MEK partner directs the ERK cascade to the surface of the late endosomes [5] Downstream scaffold proteins bind ERK and direct it to specific ... signal- responsive kinase (ERK) 1 ⁄ 2, which control several biological processes such as proliferation, differentiation, survival and apoptosis The ERK signaling pathway includes three major components...
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Báo cáo khoa học: A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts pptx
... the ERK response Previous mathematical models were focused on the control of ERK activation by hormones at short time scales of < 60 min, and the concentrations of the proteins were assumed to ... understood in terms of their transcriptional regulation downstream of ERK [44,47,51] In addition, there are other feedback regulators within the RAS–RAF–MEK ERK pathway that might contribute to signaling ... coefficients of signaling cascades are maximally the product of the Hill coefficients of the 1030 individual elements of the signaling pathway [41,42] Therefore, the remaining coefficient of at least...
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Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx
... modulation of ERK1 /2 signaling may be hampered by the fact that inhibition of one element of the ERK1 /2 signaling network may modulate other signaling units For instance, selective inhibition of MKK1/2 ... levels of the ERK1 /2 cascade as well as testing the effects of these agents on other signaling circuitries that may crosstalk to ERK1 /2 ERK1 /2 as a transducer of extrinsic survival signals The first ... production of NO and subsequent activation of Ras, which ultimately signaled to ERK1 /2 [33] The inhibition of ERK1 /2 activation in this case completely abolished the protective effects of preconditioning...
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Báo cáo khoa học: Phosphorylation of NF-jB proteins by cyclic GMP-dependent kinase A noncanonical pathway to NF-jB activation potx
... AMP-dependent kinase (PKA), can phosphorylate and activate the transcription factor CREB, the connection of PKG to gene expression is incompletely understood Recently, the localization of the PKG form ... to p50/p52 than the consensus probe Expectedly, the presence of the PKG inhibitor suppressed the superantigen-dependent induction of NF-jB but had no effect on T-cell stimulation by conventional ... inhibited by the cGMP-dependent kinase inhibitor Rp-8pCPT-cGMPS at a high concentration Consistent with the competitive function of the compound, the inhibition was complete in the absence of cGMP...
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Báo cáo y học: "Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway" pps
... experiments The graphs shows the results of densitometric analysis of bands expressed as the mean ± standard deviation (SD) of the relative fold change in band density with the ratio of the control condition ... COX-2 gene expression (P < 0.05) In the presence of laminarin there was a lower, 1.6 + 0.3-fold, but signif- Figure The effect of extracellular- regulated kinase (ERK) tion of synovial fibroblasts ... positivity In the presence of U0126 no expression of phospho -ERK1 /2 or COX-2 is demonstrable in the infected synovial fibroblasts PGE2 production To assess whether increased expression of COX-2 was...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... telomere elongation We have then examined the effects of Ser258 phosphorylation of Bud32p on the transcriptional activity of the EKC ⁄ KEOPS complex by analyzing the activation rate of the galactoseinducible ... nutrients [21] To verify whether the onset of conditions that modify the amount of Sch9p has an effect on the phosphorylation of Bud32p at Ser258, we compared the level of Bud32p phosphorylation in wild-type ... vector at the BamHI ⁄ KpnI sites [31] In this construct, the expression of the cloned gene is under the control of the CYC1–GAL1-10 promoter, allowing galactoseinducible overproduction of the...
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Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx
... phosphorylation All these results indicate that PKR dose not play only a structural role but rather modulates a signaling pathway of ASK1 Therefore the binding of PKR to ASK1 might cause a conformational ... ASK1 activity To explore the potential influence of PKR on ASK1 in vivo, the effect of PKR-KR on the ASK1-induced apoptosis was investigated We used constructs of PKR fused with EGFP to directly ... seems to be consistent with recent reports that the interaction of PKR with IjB kinase b or the signal transducer and activator of transcription1 does not require kinase activity of PKR [29,30]...
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Báo cáo khoa học: Protein kinase Ce: the mitochondria-mediated signaling pathway pot
... translocation of these proteins to the mitochondria [8,9,24,32] Involvement of PKCe in intrinsic apoptotic pathway The intrinsic pathway depends on damage to mitochondria and on the release of apoptosis-inducing ... receptors The trigger signal is transmitted to caspase-8, and then, downstream of the signaling pathways, branches into two pathways: the mitochondria-independent path way and the mitochondria-mediated ... PKCd during reperfusion induces cell death via the regulation of mitochondrial function and induction of apoptosis A recent discovery on the effect of novel PKC isoforms on apoptosis is that phospholipid...
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