... heteroplasmy During cell division of heteroplasmic cells, cytokinesis will lead to the distribution of mutant mtDNA to other daughter cells, and as a consequence may lead to an expansion of homoplasmic ... overwhelm any inherent biological defence, eventually triggering overt liver injury The notion of abnormal mitochondria playing theroleof a susceptibility factor in DILI is relatively new, and ... absence of albumin, where albumin sequesters 95 to 99% of plasma troglitazone, thereby reducing the bioavailability (pharmacologically and toxicologically) 18 ofthe drug (Chojkier, 2005, Loi et al.,...
... reaction intermediate, FVaint This facilitated the determination of loss of FVa cofactor activity during the initial stage of inactivation and minimized thein uence ofthe k306 Ó FEBS 20 04 Heparin and ... heparin inhibits cleavage at Arg506 and stimulates initial cleavage at Arg306, inactivation of Fig Kinetic analysis ofthe inactivation of FVa by APC inthe presence and absence of heparin Initial ... clotting factors Blood 78, 1637–1651 Esmon, C.T (1989) The roles of protein C and thrombomodulin inthe regulation of blood coagulattion J Biol Chem 2 64, 47 43– 47 46 Kalafatis, M., Rand, M., D., Mann,...
... seems likely that the mechanism of release ofthe axial ligand under alkaline conditions andinthe presence of GdmHCl is different Under alkaline conditions release ofthe axial ligand is postulated ... as the open form, albeit with the axial ligand still intact, with the main- and side-chain atoms of K99 flipped up and away from the heme resulting in an increased solvent exposure ofthe heme The ... the local unfolding of this region is not under sole control ofthe axial ligand If so then this suggests the region around the K100 ligand is less stable than inthe wt protein This is also inferred...
... cells over-expressing D 14- SR; no label was observed in control cells These results are consistent with the known subcellular localization ofthe enzymes involved in cholesterol biosynthesis and ... Cellular localization The cellular localization of myc-tagD 14- SR was examined in transiently transfected COS-7 cells Double immuno¯uorescence analysis of cells showed a similar labelling pattern with ... C27D8, 14 sterol C27D8 sterol was undetectable at the beginning of incubation both in COS-7 cells and bovine liver microsomes Endogenous D 14- SR activity of microsomes obtained from control COS-7 cells,...
... changes in O2–Æ concentration within living cells Overall results establish the potential value ofthe probe for facilitating investigations ofthe generation, metabolism, and mechanisms of superoxide-mediated ... Perkin–Elmer, Norwalk, CT) All pH measurements were made using a pH-3c digital A solution of 40 .0 mL of dimethylformamide in 40 .0 mL of methylene chloride was chilled in an ice bath A solution of ... radicals In order to further investigate the feasibility ofthe proposed method in biological systems, determination of O2–Æ incell extracts was performed The fluorescence intensity ofcell extracts...
... Biotin is too large to penetrate the outer membrane and will only label polypeptides that have a lysine-containing sequence accessible at thecell surface The biotinylated cells Heme protein identification ... sample applied); lane 2, 20 mM Tris ⁄ HCl wash (20 lL sample applied); lane 3, 0.5 M NaCl extract (20 lL sample applied); lane 4, whole cells treated with 0.5 M NaCl (10 lL sample applied); lane ... PAGE displayed a complex crude cell- extract protein pattern inthe untreated cells andin cells treated with 0.5 and m NaCl (Fig 5A, lanes 1, and 6) Importantly, the large 60 kDa subunit ofthe MeDH...
... Between EU and Asia After the Cold War, the int l society became tri-polar with US, Europe and Asia >> In 1996, resulted inthe establishment ofthe Asia-Europe Meeting (ASEM) Political Idealism ... Singapore, Indonesia, Philippine, Thailand, ASEM ASEAN Int l ICT, IR, 27 Europe-Asia Link to SEA Korea France TEIN II Link (34Mbps) Malaysia Int l ICT, IR, 28 Considering Points ICT hub in NEA ... China Greece, Netherlands, Denmark, Germany, Luxemburg, Belgium, Sweden, Spain, Ireland, UK, Austria, Italy, Portugal, France, Finland, EC Laos, Cambodia, Myanmar, Malaysia, Brunei, Vietnam, Singapore,...
... tolerate artificially increased levels of PMLA The data in Table allow calculation and comparison ofthe PMLA contents of nuclei in a variety of strains These nuclear contents vary relatively little, ... comparable levels inthe nuclei We found that increased cytoplasmic and nuclear levels of PMLA induced a strain specific enhancement ofcell growth and an equal (between strains) shortening ofthecell ... high and low producers of PMLA (Table 1) In order to study changes inthe levels of PMLA in cytoplasm and nuclei, we injected 40 0 lg ofthe polymer into M3CVII and LU887 plasmodia (weights of 150...
... cellular level (Pelletier, 19 94) Qj is the quality of prenatal and child 10 medical care available in community j We assume that technical quality changes slowly andthe values of quality and other ... including maternal health status andthe timing ofthe insult itself (Hall and Peckham, 1997) Persistent untreated illness early and throughout the pregnancy can result in a reduction of placental ... growth in low-income settings is largely the result of factors amenable to intervention Sound child health policies promote investments in improving the content and quality of prenatal and child...
... surrounding the vacuolated mucus-secreting cells ofthe gill (Fig 7B), principally within the epithelium ofthe primary lamellae and secondary lamellae The mucus-secreting cells stained positively ... BM4 147 (VanA+, clinical isolate), E faecalis V583 (VanB+, clinical isolate) and Entero- A flounder LAAO-like antibacterial protein coccus gallinarum BM41 74 (VanC1+, clinical isolate); andthe gram-negative ... showed that psLAAO-positive cells were present inthe gill These results suggest that psLAAO has tissuespecific expression and is localized in gill Interestingly, using cloning analysis, we identified...
... to the practice of certain virtues Thus we contrast profits and patriotism; enriching one's self and philanthropy; getting all the law allows and justice; taking advantage ofthe other fellow and ... could well be replied that consideration of patriotism, philanthropy, love of family, etc., must in themselves impel one to earn and to save "The love of money is the root of all evil" implies ... on the other hand, the ordinary man will make to himself every excuse He will contemn money-making as a sordid aim, readily exaggerating itself into a vice; he will dwell upon the obligations and...
... Cleveland bay, Belfounder Eclipse, American points of habits breeding management of colts breaking longevity, feeding Diseases glanders 140 142 143 143 144 145 141 146 147 148 149 150 151 1 54 ... 1 54 lampas, heaves, &c catarrh or distemper, spasmodic colic flatulent colic inflammation of bowels physicking worms bots wind-galls the fetlock cutting sprain ofthe coffin-joint— ringbone enlargement ... perpetuate inthe offspring 2d These qualities, technically called points, should be inbred inthe animals as far as practicable, by a long line of descent from parents similarly constituted The necessity...
... content in needles of healthy trees is inthe range of4 6 g·kg–1 (Fig 1) and it decreases below the limit value of g·kg–1 in 50% ofthe plots K content in needles of damaged trees is statistically ... (1993): Effects of drought on the yellowing status andthe dynamics of mineral elements inthe xylem sap of declining spruce (Picea abies [L. ] Karsten) Plant and Soil, 150: 303–306 D L. , KŪ ... the limit ofthe lower optimum of 130 mg·kg–1 Inthe subsequent organomineral horizon (Ae/Ep) the values of Ca indicate the lower optimum reserves inthe range of 80–160 mg·kg–1, andin 15% of...
... addition, intracellular proline levels are correspondingly low When proline is added, intracellular proline levels recorded correspond approximately to the amount of proline added to each culture ... cold and salt stresses, cultures were maintained for 14 days Every days, the flasks were briefly removed from the orbital shaker, the cells allowed to settle for 10 andthe volume of settled cells ... Effect of NaCl salinity on growth and mineral partitioning in Quercus robur L. , a rhythmically growing species, Trees 12 (1998) 42 4 43 0 [2] Aspinall D., Paleg L. G., Proline accumulation: physiological...
... iv) the relationship between radial increment and a single defoliation was much closer inthe upland and floodplain stands (correlation coefficients around 0 .48 and 0.62, respectively) than inthe ... lowest inthe floodplain and riverbank stands Since the crowns are more frequently damaged by insects in floodplain stands, these latter have probably developed a defence mechanism, in principle ... Bohin and E Dreyer for help in organizing his participation inthe meeting in Nancy, France the floodplain stand presenting the highest ratios and most severe decreases, andthe solonetz, the lowest...
... all PFD, water stress resulted in lower values of ΔF/F in Q petraea and Q rubra m’ Lower ΔF/F in stressed individuals was m’ probably induced by low CO availability at the chloroplast ... chlorophyll contents, leaf-specific weight and leaf optical properties could partly explain these differences in A Lin and Ehleringer (1982) reported that changes in spectral properties of leaves of ... visible light Annu Rev Plant Physiol 35, 15 -44 Schulze ED, Hall AE (1982) Stomatal responses, water loss and CO assimilation rates of plants in contrasting environments In: Physiological Plant...