... VII The Veins Introduction The Pulmonary Veins The Systemic Veins a The Veins oftheHeart b The Veins ofthe Head and Neck The Veins ofthe Exterior ofthe Head and Face The Veins ofthe Neck The ... Surface Anatomyofthe Back Surface Markings ofthe Back Surface Anatomyofthe Thorax Surface Markings ofthe Thorax Surface Anatomyofthe Abdomen Surface Markings ofthe Abdomen Surface Anatomyof ... Portion ofthe Sympathetic System b The Cervical Portion ofthe Sympathetic System c The Thoracic Portion ofthe Sympathetic System d The Abdominal Portion ofthe Sympathetic System e The Pelvic...
... root ofthe mesentery ofthe intestine The lymphatic vessels ofthe right half ofthe head and neck, the right thorax, and the right upper limb drain toward the right venous angle; those ofthe ... self-explanatory To all regions ofthe body we added schematic drawings ofthe main tributaries of nerves and vessels, ofthe course and mechanism ofthe muscles, ofthe nomenclature ofthe various regions, ... lines of orientation are used, e.g., the parasternal line, the midclavicular line, the anterior axillary line, the umbilical-pelvic line By means of these lines, theheart and the position of the...
... almost all ofthe OLP epithelium The count was performed by two investigators without knowledge of whether the samples were control or experimental The total number of basal and suprabasal epithelial ... PermountTM Negative controls consisted of omission ofthe primary or the secondary antibody or primary incubation in the presence of non-immunized rabbit serum instead ofthe primary antibody Cell quantification ... Statistical analysis The immunolocalization of hMSH2 was quantitatively analyzed Epithelial cells were considered to be positive if there was any staining ofthe nucleus, regardless of staining intensity...
... referring to parts ofthehuman body The position of proverbs referring to part ofthehuman body Parts ofthehuman body 21 21 21 The classification of parts ofthehuman body according ... diversified (multiple form) The classification of parts ofthehuman body according to the position In the system ofthe proverbs, the system of words referring to parts ofthehuman body is divided ... cánh tay The combination of different parts ofthehuman body are often found in proverbs, face is often with heart , tongue or lips with teeth etc Often the opposite parts ofthehuman body...
... earth The hand of a child - The hand of a lock Theheartof a man - Theheartof a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of a comb The head of a ... hands of a farm 13 The heel of a person - The heel ofthe hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom ofthe church 17 The ... parts oftheheart 7) Backbone 1 .The line ofthe bones down the middle ofthe back from the skull to the hips ,the spine 44 2 .The chief support of a system or an organization Strength of charater...
... product of PRPP from the crystallization solution ing 81 compounds of substrates, products and regulators of other enzymes in thehuman nucleotide metabolism (Table S1) The library can then be ... interacts with both O6 and N7 (Fig 1C) The 2¢OH ofthe ribose is hydrogen bonded to the main chain and the side chain of Asp142 (Fig 1C) Both hydroxyl groups ofthe ribose are involved in coordinating ... ligands for enzymes in thehuman nucleotide metabolism These were selected as substrates, intermediates and products of other enzymes in thehuman nucleotide metabolism The library was screened...
... monomer of poly(dT), showing that the changes were mainly due to the binding ofthe first DNA, while the binding ofthe second DNA had less influence (Fig 5A) To ensure that the estimation ofthe protein:poly(dT) ... in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops ofthe eukaryotic Rad51 proteins face A Roles ofthe HsRad51 L1 and L2 loops inside of their ... precision of 3% The changes occurring upon the addition ofthe element are noted in parentheses ND, not determined Y Matsuo et al ciation, like the case of Tyr188 of Xenopus laevis Rad51 [28] These...
... type of KLK11, isoform 2, despite the presence of exon 1c The secretory pathways of KLK11 isoforms appeared to differ, although both isoforms were secreted from cells Hence, the promoter use ofthe ... the isoform of translation products through the determination ofthe first exon in KLK11 mRNA (summarized in Fig 2A) Detection ofthe first exon in each KLK11 mRNA reflects the promoter use in the ... a part of isoform mRNA The third exon, exon 1c, extended from +1379 to +1454 The noncoding exons of exons 1a and 1c contributed to the 5¢ nontranslated region of isoform mRNA in which the common...
... functionality and phylogeny However, the nature ofthe connections between these factors needs to be understood at the level ofthe protein domain The global properties ofthe HTFN topology are partially ... graph of N ¼ 230 interacting human TFs was obtained (Fig 1) This can be understood as the architecture ofthe regulatory backbone It provides a topological view ofthe interaction patterns among the ... subset of interacting proteins responsible for the control of gene expression They interact with DNA regions and tend to form transcriptional regulatory complexes Thus, the final effect of one of these...
... in Fig In order to gain further insights into the modes of regulation of TPb, the aim ofthe current study was to map the minimal transcriptional unit and to identify the key regulatory elements ... regions of Prm3 The following lists the identities ofthe Prm3 gene fragments and corresponding plasmids generated in either pGL3Basic (pGL3b) or pGL3Enhancer (pGL3e) vectors and the identity ofthe ... anticipated that the functional characterization of Prm3 reported herein should provide critical knowledge ofthe modes of regulation of TPb expression and hence may shed further insights as to the physiologic...
... affinities to the protein of interest In the case ofthe rpL32 fragment or the (GCC)9 sequence, there are several repeated ZF5-binding sites within a single oligonucleotide Therefore, the affinity of those ... Identification of a GC element in the promotor ofthe murine L32 ribosomal protein L32 gene and the 3¢-terminal region ofthehuman apolipoprotein A-I gene, capable of binding with murine and human cells ... repressor ofthehuman FMR1 gene Given that FMR1 inactivation in FMR patients has been attributed to long (GCC)n triplet repeats within the 5¢-UTR ofthe FMR1 gene, further investigations to clarify the...
... of MUC5AC Fig Mapping ofthe 45M1, 166M1 and 2-12M1 epitopes on the C-terminal cysteine-rich part ofhuman MUC5AC The upper part ofthe figure shows a schematic representation of full-length human ... ofthe epitopes for the mAbs, where 45M1 recognizes an epitope located in the N-terminal region ofthe C-terminal cysteine-rich part of MUC5AC, presumably in the last CysD domain ofthe mucin The ... cysteine-rich part Further localization ofthe epitopes of 45M1, 2-12 M1 and 166M1 In order to further locate the epitopes ofthe hitherto unmapped 45M1, 2-12M1 and 166M1, these mAbs were screened...
... subunit of Pph3p required for the binding of Psy2p, we examined the sensitivity ofthe YBL046w ⁄ Psy4p deletion strain to cisplatin The comparable increased sensitivities to cisplatin ofthe homozygous ... identical to those ofthe wild-type cells Examination ofthe phenotype of S cerevisiae carrying deletions for both the YBL046w gene and the TUB2 gene Since decreased expression of Ppp4c in D melanogaster ... the proteins are difficult to align because identity between the two proteins is low Nevertheless, the alignment in Fig shows that the overall similarity ofthe protein encoded by YBL046w to human...
... percentages ofthe cells in the G0 ⁄ G1, S and G2 ⁄ M phases ofthe cell cycle after treatment with 20 lM or 100 lM ATP for 24 h The gating used for the quantification ofthe cells in the G0 ⁄ G1 ... Inhibition of proliferation of LXF-289 lung tumor cells Effects of P2 receptor agonists The influence ofthe different P2 receptor agonists is shown as percentage inhibition ofthe proliferation of LXF-289 ... decrease ofthe p50 form of NF-jB1 in the cytosol after 10 min, which is still visible after 60 (Fig 5D) Simultaneously with the decrease of p50 in the cytosol, an increase of NF-jB1 p50 in the nuclear...
... and late steps ofthe process For example, early in the NER process, RPA assists TFIIH in the opening ofthe DNA helix around the damage site [36] Furthermore, in the presence ofthe XPA minimal ... sites Taken together, these findings suggest that the structural properties of DNA-damaged substrates, whether intrinsic or the result of protein binding, function in the recruitment ofthe XPC–hHR23B ... domain ofhuman ERCC1 closely resembles the nuclease domains of XPF from humans and other organisms, despite low percentages of sequence identity Investigations into DNA interaction ofthe protein...
... regions ofthehuman ANT2 promoter are shown in grey The two Sp1 AB box activation elements are shown as open symbols (B) DNA sequence ofthe silencer region (nucleotides )413/)235) ofthehuman ... transfection efficiency The values ofthe activities are set relative to the activity ofthe clone carrying wt Site-2 and Site-3 elements The results represent the mean value ± S.E of five independent ... Identification ofthe Site-2 and Site-3 binding protein as a member ofthe NF1 family of transcription factors (A) Binding of purified, recombinant NF1 to the Site-2 and Site-3 elements was monitored by the...
... membrane expression [6] In the absence of positive transport signals, the localization of a protein in the ER may result from the properties ofthe TMD and its interaction with the membranes It has ... colocalized with the ER marker protein, calnexin (Fig 4B) Taken together, these data indicated that the TMD domain of UGT1A was sufficient to retain the ectodomain of CD4 protein in the ER Because the carbohydrate ... that disruption ofthe dilysine motif KSKTH of UGT1A by mutation of lysine to serine residues or by extending the length ofthe cytoplasmic tail to relocate the dilysine from the critical positions...
... further our knowledge with respect to the mechanisms of action of these proteins, it is crucial that we define the precise boundaries ofthe STI1-homologous domain and compare the structures of these ... 2A) The N-terminal part of XPCB–hHR23B B C Fig NMR structure ofthe XPCB domain of hHR23B (A) Stereoview ofthe 12 superimposed structures of XPCB–hHR23B All Pro residues conserved among the ... considering the local structure For example, the structure of hHR23B I306 differed significant from that ofthe corresponding residue (L262) of hHR23A I306 was well ordered and was part of a hydrophobic...
... within their carboxyl terminal domains [30, 31] Whilst the biologic significance for the existence of two TP isoforms in humans has not been fully elucidated, there is extensive evidence that they ... expression ofthehuman TP gene within the platelet progenitor megakaryocytic human erythroleukemic (HEL) 92.1.7 cell line Moreover, in view ofthe existence of two independently expressed TP isoforms ... down-regulation of TPb mRNA expression These data provide further evidence for the role of PPARc in the regulation of TP gene expression within the vasculature and point to further critical differences...
... the rate of transcription initiation ofthe PS1 gene in SK-N-SH cells To determine whether the increase in the level of PS1 mRNA results from the activation ofthe transcription ofthe gene we ... newly synthesized PS1 in the presence of TPA does not appear against the background ofthe larger cellular pool ofthe stable 30 kDa form Hence we observe an increase in the level ofthe PS1 protein ... threefold in the presence of TPA Thus the increase in the level of PS1 mRNA observed by Northern blotting of total cellular RNA results from an increase in the rate of initiation of transcription of PS1...