gastric cancer and helicobacter pylori
Risk factors for gastric cancer and risk stratification in singapore chinese population
... with gastric cancer each year worldwide, making gastric cancer the 4th most common cancer Half of the global burden occurs in East Asia Gastric cancer is also the second leading cause of cancer ... known risk factors for gastric cancer are Helicobacter pylori (HP) infection, diet with high intake of salt and preservatives, smoking, alcohol, family history of gastric cancer and pernicious anemia ... of stomach cancer in the world and in Eastern Asia 14 Figure 1.3 Estimated Gastric Cancer Incidence and mortality Worldwide in 2008 in male and female 15 Figure 1.4 Trends in gastric cancer incidence...
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Báo cáo y học: No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanes
... characteristics of patients according to H pylori infection and gastric atrophy are shown in Table 100 Age was significantly associated with H pylori infection and gastric atrophy There were no significant ... concentrations of 101 serum folate and tHcy were found between the positives and the negatives of H pylori infection and gastric atrophy according to the genotypes of MTHFR and TS in any subgroups defined ... between Helicobacter pylori infection, gastric inflammation and serum homocysteine concentration Helicobacter 2001; 6: 146-50 Sipponen P, Laxen F, Huotari K, et al Prevalence of low vitamin B12 and...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... between Helicobacter 22 pylori and gastric mucosa in the pathogenesis of body atrophic gastritis Gastroenterology 1996, 111:655-665 Parsonnet J, Friedman GD, Vandersteen DP: Helicobacter pylori ... treatment and cultured in the absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Page of Soybean trypsin inhibitor (SBTI) augments H pyloriinduced ... absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Figure Soybean trypsin inhibitor (SBTI) augments H pyloriinduced cell death and DNA fragmentation...
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Báo cáo khoa học: "High grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literature" pdf
... to subtotal gastric resection The histological examination revealed complete remission of the lymphoma and absence of Helicobacter pylori He did not receive additional treatment and is in continuous ... Isaacson and Wright [30], there is a sequence of events without solution of continuity from acquisition of gastric MALT, in most cases because of a Helicobacter pylori infection, to MALT lymphoma and ... primary gastric DLBCL associated with Helicobacter pylori infection a complete staging with endoscopic ultrasonography, computed tomographic imaging and bone marrow biopsy should be carried out and...
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Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
... and light strands of the mtDNA, and contains essential transcription and replication elements The D-loop region is a hot spot for mtDNA alterations and the nucleotide positions 16024±16 324 and ... of nuclear and mitochondrial DNA in gastric cells Clin Cancer Res 2009;15: 2995-3002 Lee S, Shin MG, Jo WH, et al Association between Helicobacter pylori- related peptic ulcer tissue and somatic ... apoptosis and DNA damage: implications for gastric carcinogenesis Cancer Res 2004;64:8521-8525 26 Nagata K, Yu H, Nishikawa M, et al Helicobacter pylori generates superoxide radicals and modulates...
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Báo cáo y học: " Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF"
... band for the 681G allele and a 105-bp band for 681A allele, with a 191-bp their common band, and a 377-bp band for 636G allele and a 255-bp band for 636A allele, with a 597-bp their common band ... Malfertheiner P, Sipponen P, Naumann M, et al H pylori -Gastric Cancer Task Force Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique Am J Gastroenterol ... Mukai T, Okamoto S, et al Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer Cancer Epidemiol Biomarkers Prev 1997;...
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Tài liệu Báo cáo khoa học: Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori docx
... gene encoding SDH from H pylori strain SS1 The recombinant H pylori shikimate dehydrogenase (HpSDH) was cloned, expressed, and purified in E coli system, and its biochemical and enzymatic characterizations ... (Eqn 2) On the other hand, compounds 1, 4, and are noncompetitive inhibitors, and compounds and are competitive inhibitors with respect to NADP Table summarizes the IC50 values and kinetic inhibition ... against H pylori The results show that compounds 1, 2, and display moderate inhibitory activity against the growth of H pylori strains ATCC 43504 and SS1 in vitro with MIC values of 16, 16, and 32...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... (2002) Helicobacter pylori infection N Engl J Med 347, 1175–1186 ´ Fischer W, Karnholz A, Jimenez-Soto LF & Haas R (2008) Type IV secretion systems in Helicobacter pylori In Helicobacter pylori ... Helicobacter pylori Nature 464, 250–255 Cendron L & Zanotti G (2011) Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag pathogenicity island ... structure of CagS from the Helicobacter pylori pathogenicity island Proteins 69, 440–443 Bourzac KM, Satkamp LA & Guillemin K (2006) The Helicobacter pylori cag pathogenicity island protein CagN is...
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Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... 2007LHN9JL) and by the University of Padua, Italy References Parsonnet J (1994) Gastric adenocarcinoma and Helicobacter pylori infection West J Med 161, 60 Goodwin CS (1997) Helicobacter pylori gastritis, ... (2011) Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus FEBS J 278, 1203–1212 Hatakeyama M (2006) The role of Helicobacter pylori CagA in gastric carcinogenesis ... be distinguished Helices B, E, F and H, arranged in an up -and- down topology, form the structural core, whereas the short helices C, D and G on one side, and A, I and J on the other, represent types...
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MANAGEMENT OF OESOPHAGEAL AND GASTRIC CANCER ppt
... PRESENTATION AND REFERRAL RISK FACTORS Oesophageal and gastric cancers occur mainly in people over 55 years of age Male sex is a risk factor for squamous cancer of the oesophagus and for oesophagogastric ... adenocarcinoma and with a risk of oesophagogastric junction cancer The presence of Helicobacter pylori infection is associated with a two to threefold increase in the risk of developing gastric cancer ... oesophagogastric junction cancer Deprivation is a risk factor for development of squamous cancer of the oesophagus and for gastric cancer Tobacco smoking increases the risk of squamous cancer of the oesophagus...
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Báo cáo khoa học: Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway – evidence of a different substrate specificity doc
... (1999) Helicobacter pylori virulence and genetic geography Science 284, 1328–1333 Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N & Sibley RK (1991) Helicobacter pylori ... infects the human gastric mucosa It has been associated with the development of several diseases, such as chronic gastritis, gastric and duodenal ulcer, gastric adenocarcinoma and mucosa-associated ... 4-amino-5-aminoethyl-2methylpyrimidine: with a kcat and KM of 1.7 ± 0.2 min)1 and 58 ± 22 lm, respectively The F47Y variant appears to be poorly active as well: with a kcat and KM of 0.06 ± 0.006 min)1 and 68 ± 16 lm, respectively...
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Báo cáo khoa học: Purification and characterization of Helicobacter pylori arginase, RocF: unique features among the arginase superfamily doc
... Mechanisms of Helicobacter pylori infection: bacterial factors In Current Topics in Microbiology and Immunology Gastroduodenal Disease and Helicobacter Pylori: Pathophysiology, Diagnosis and Treatment ... arginase in cancer of the stomach Virchows Arch 428, 325–331 29 Weeks, D.L., Eskandari, S., Scott, D.R & Sachs, G (2000) A H+-gated urea channel: the link between Helicobacter pylori urease and gastric ... Parsonnet, J., Friedman, G.D., Vandersteen, D.P., Chang, Y., Vogelman, J.H., Orentreich, N & Sibley, R.K (1991) Helicobacter pylori infection and the risk of gastric carcinoma N Engl J Med 325,...
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Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt
... Krishnan AV (2000) Vitamin D and prostate cancer Endocrinology 141, 5–9 Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease ... Schmidt N, Dietzmann K & Malfertheiner P (2002) Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives Eur J Gastroenterol Hepatol 14, 297–303 Pan L, Lu J, ... D as a novel molecular target in gastric cancer therapies in association with the use of TSA ⁄ NaBu and 5-Aza Results Vitamin D induced apoptosis in gastric cancer cells through PTEN upregulation...
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Management of oesophageal and gastric cancer doc
... females: 7% to 13%) and gastric cancer (males: 6% to 13%; females: 9% to 18%) it remains low Management of oesophageal and gastric cancer 1.2 Scottish audit of Gastric and Oesophageal cancer The Scottish ... 6.5% Oesophageal and gastric Cancer causes of death in Scotland 2004 (excluding non-melanoma skin cancer) 26.2% 10.3% Trachea, bronchus and lung Colorectal 9.4% Oesophageal and gastric 7.3% Breast ... Figure 1) Figure Cancer diagnoses and cancer deaths in Scotland1 Most common cancers in Scotland 2002 (excluding non-melanoma skin cancer) 17.7% 14.1% 13.0% 9.0% Trachea, bronchus and lung Breast...
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Báo cáo khoa học: Helicobacter pylori single-stranded DNA binding protein – functional characterization and modulation of H. pylori DnaB helicase activity pptx
... fluoride and 10% glycerol For helicase and ATPase assays, HpSSB (Wt) and DC20SSB were dialysed against MonoQ and MonoS buffers and subjected to ion exchange chromatography using MonoQ and MonoS ... containing 540 bp and 480 bp of H pylori SSB full length and C-terminal deletion mutant pET28a derivative containing 1.5 kb of H pylori dnaB pGEX derivative containing 1.5 kb of H pylori dnaB F ± ... Wt and DC20 SSB protein in varying concentrations (0, 0.45, 0.9, 1.8, 2.7 and 3.6 lg, respectively) with 300 ng of M13mp18 single-stranded circular DNA and ⁄ or 300 ng of pUC18 double-stranded...
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báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... 16.5 ± 27.4 42 46.3 ± 551.5 14.1 ± 13.2 EGC, early gastric cancer; ACG, advanced gastric cancer; GC, gastric cancer; H pylori, Helicobacter pylori; mucosa; sm, sub-mucosa; mp, muscularis propria; ... different between the AGC group (*) and M group (†) (ANOVA with Post HOC Scheffe, p > 0.05) GC, gastric cancer; EGC, early gastric cancer; AGC, advanced gastric cancer Page of 11 (page number not ... specimens in the non -cancer groups and via biopsy and surgical specimens in the cancer groups All cancer patients were diagnosed for the first time during the enrollment period and their blood samples...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... malignant gland compared to normal gland, especially nearby the BM (Figure 2C) High density of macrophages was observed at the juncture of cancer cells and stroma where BM integrity of gastric gland ... cancer microencironment and cancer cells and promoted by those components MMPs are major proteolytic enzymes to breakdown ECM during cancer invasion Traditionally, extracellular proteolysis and ... interface of tumor nest and stroma is the main location of infiltrating macrophages in gastric cancer, and phagocytosis of cancer cells by macrophage, indicating the coexistence of M1 and M2 phenotypes...
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Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf
... of gastric cancer, we previously established the gastric cancer cell lines mGC8 and 424GC from CEA424-SV40 TAg-transgenic C57BL/6 mice [25] These cell lines express epithelial cell markers and ... Germany) For tumorigenicity and immunogenicity assays female mice were used at 812 weeks of age The gastric cancer cell lines mGC8 and 424GC were established previously from gastric tumors which developed ... contributions NKE and HW designed the animal experiments DR provided support, discussed the data and reviewed the manuscript NKE and MR planned and conducted the experiments and discussed the...
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GASTRITIS AND GASTRIC CANCER – NEW INSIGHTS IN GASTROPROTECTION, DIAGNOSIS AND TREATMENTS docx
... Medici and Graciela Font de Valdez 153 Helicobacter Pylori Infection in Gastritis and Gastric Cancer 177 Chapter 10 Gastric Cancer Risk Diagnosis and Prevention in Subjects with Helicobacter pylori- related ... of Helicobacter pylori and Their Relationship with the Development of Early and Advanced Distal Intestinal Type Gastric Adenocarcinoma 259 Bruna Maria Roesler, Sandra Cecília Botelho Costa and ... to the mucosal surface and the gastric lumen in a solubilized Gastritis and Gastric Cancer – New Insights in Gastroprotection, Diagnosis and Treatments Fig Composition of gastric mucus condition...
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