elucidating the path from genotype to behavior in honey bees insights from epigenomics
RUNX3 acts as an ocogene through a hedgehog dependent pathway in selected human neoplasms
... and Purkinje layers to form the IGL Maintained autocrine SHH signaling in the EGL (E) may result in the development of cerebellar tumors 13 Table Mutations in the SHH signaling pathway in medulloblastomas ... GLI 15 The delineation of the SHH signaling pathway, the recognition that aberrant SHH signaling may lead to certain cancers, and the understanding of the pathway inhibition have led to the development ... proteosomes to the repressor form (GliR), which represses transcription to the target genes (B) Signaling in the pathway is initiated by the SHH ligand binding to PTCH, which releases the inhibition...
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Báo cáo khoa học: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma pdf
... containing mutations in the region encoding the miR-373 binding sites These results show that miR-373 binds directly to the 3¢-UTR of the PPP6C transcript to repress gene expression To determine ... protein (EGFP) reporter vector (pcDNA3 ⁄ EGFP-PPP6C-3¢UTR), in which the 3¢-UTR fragment of PPP6C, including the region encoding the putative binding site, was inserted downstream of the EGFP coding ... target the PPP6C transcript, the binding sites in nucleotides 1363–1369 of the 3¢-UTR are different from the miR-373-binding sites in nucleotides 1338–1344 of the 3¢-UTR, which not overlap Whether...
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báo cáo hóa học: " Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes" docx
... genes involved in the production of many pro-inflammatory cytokines and enzymes related to the inflammatory process Activation of NF-B is critical for the expression of various cytokines, iNOS, ... in microglia in response to LPS [16] Normally NF-B remains inactivated by an inhibitory protein, IB Once activated, NF-B enters the nucleus to increase transcription of different inflammatory ... of these anti-inflammatory agents is to suppress neuroinflammation, primarily through their ability to inhibit COX, leading to reduced biosynthesis of proinflammatory molecules in glial cells...
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Báo cáo y học: "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note" potx
... commenced in the supine position with the head extended and turned to the opposite side and the injured arm in an adducted position The skin incision was extended inferiorly over the lower 1/3rd of the ... are the thoracic intercostals, the medial pectoral, the phrenic and the spinal accessory nerves Intraoperative monitoring of nerve repair using electrodiagnostic techniques aids the surgeon in the ... and increase the duration of the procedure.[7] On the other hand, capnography is a routine and mandatory anaesthetic monitoring device In this study, a notch in the capnograph could be obtained...
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Báo cáo y học: "Correspondence in relation to the case report "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note." published in May issue of Journal of Brachial Plexus and Peripheral Nerve Injury" potx
... mentioned anything about the ventilator rate and tidal volume setting in their particular case in relation to capnogram recording Hypocarbia can result from several causes Most common of them is hyperventilation ... (iatrogenic or induced by patient due to inadequate anesthesia) [1] Again premature respiratory effort due to painful electrical stimulus can lead to hyperventilation leading to reduction of ... progressive reduction in ETCO2 level in subsequent capnogram tracings But they have not given any valid explanation to the cause of this occurrence Ventilator setting here is very important They have not...
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Báo cáo y học: "Response to comments on "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note"" docx
... Peripheral Nerve Injury 2008, 3:21 http://www.jbppni.com/content/3/1/21 With increase in the amplitude of current, there is further increase in the force of diaphragmatic contraction (akin to hiccups) ... fall in ETCO2 We hope the response addresses the concerns of the reader Thanking you Hemant Bhagat, Anil Agarwal, Manish S Sharma Competing interests The authors declare that they have no competing ... competing interests They did not receive any grants nor they have any vested interests in the equipment described References Akcali DT, Ozkose Z, Yardim S: Do we need bispectral index monitoring during...
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Báo cáo y học: "Ketamine as an adjuvant in sympathetic blocks for management of central sensitization following peripheral nerve injury" pptx
... likely not exclusive to pain, but rather are likely to play significant roles in other behavioral phenomena The supraspinal structures involved in maintaining neuropathic pain are rostral ventromedial ... type of receptors may either decrease the inhibitory receptors like GABA or increase in the excitatory receptors like NMDA [8] These plastic changes that increase the sensitivity of the central ... basis for the use of Ketamine to block the cellular mechanisms that initiate and maintain these changes Both subanesthetic infusions and Ketamine induced coma have been described in the successful...
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Báo cáo khoa học: " Geographical Information System (GIS) as a Tool in Surveillance and Monitoring of Animal Diseases" potx
... Alternatively, the information in the database can be accessed through the ODBC interface A goal of the introduction of GIS is to have maps continuously displaying the situation for each of the diseases included ... at a time with the starting point at the top With a GIS the spatial aspects can be included in the eradication program To avoid re-infection from nearby herds of another level, the program can ... Further, the maps can assist the field veterinarians to plan their work in the current situation, and for the veterinary authorities in how to handle a potential outbreak Analysis of clustering...
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Báo cáo y học: " A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus" docx
... identified in the V3 domain of GUN-1WT, GUN-4V, and GUN-7WT strains That is, the amino acid substitutions at the tip of the V3 domain from proline to serine or from proline to threonine can affect ... sequences in the V3 domain of the Env can give HIV1 the ability to use various GPCRs as coreceptors Coreceptors other than CCR5 and CXCR4, that are related to the clinical involvement of the HIV-1 infection ... and then exposed to HIV-1 in an amount corresponding to × 104 cpm of RT activity After removing the inocula, the cells were incubated at 37°C in E-MEM containing 10% (v/v) FCS for four days To investigate...
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Application of titanium silicide as an interconnect in deep submicron integrated chip manufacturing
... Background Since the invention of the integrated circuit (IC) by Kilby & Noyce in 1959, investigation of the materials and their integration into the manufacturing processes has been an integral ... contain sharp lines from the standard and broad lines from the unknown Let βs be the measured breadth, at half-maximum intensity, of the line from the standard Then β is given, not simply by the ... diffraction line near the line from the unknown which is to be used in the determination A diffraction pattern is then made of the mixture in either a Debye camera or, preferably, a diffractometer...
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Application of titanium silicide as an interconnect in deep submicron integrated chip manufacturing 2
... temperature during RTA1 From Figure 5-2(b), the increase in the sheet resistance with decreasing line widths for specimen A can be observed, indicating the area-dependency of the C49-toC54 TiSi2 ... titanium being annealed with induced Eddy currents generated by induction coils From the setup shown in Figure 7-2, Eddy currents induced by the inductor coils would flow mainly in the titanium ... reduces the area-dependency of the C49 -to- C54 TiSi2 phase transformation The initial effect of having a spike in RTA1 is believed to increase the nucleation rate of the C49-TiSi2 phase This is why the...
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Báo cáo khoa học: Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells pptx
... reporter plasmid containing the luc gene linked to a 1.2 kb fragment of the 5¢-flanking region of the hsp105 gene [12] or p173OR reporter plasmid containing the b-gal gene linked to the Hsp70B promoter, ... were grown in Eagle’s Minimum Essential medium (Nissui Pharmaceutical) containing 10% bovine serum in a CO2 incubator at 37 °C Screening for Hsp modulators A reporter plasmid containing the Hsp105 ... into C3H10T1/2 cells (1 · 107 cells per 100 mm dish) with 30 lL lipofectAMINE reagent (Invitrogen) according to the manufacturer’s instructions, and incubated for 48 h Cells were then maintained...
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USING BRAND AS AN EFFECTIVE WEAPON TO COMPETE IN THE MARKET: A CASE STUDY OF NHAT LINH COMPANY
... LEVERAGING LEVERAGING THE BRAND THE BRAND Line Extensions Line Extensions in existing in existing Product Class Product Class Stretching the Stretching the Brand Vertically Brand Vertically in existing ... determination to use modern marketing 33 techniques to develop and maintain its position in the markets In the words of the Company’s director it wants to build strong LiOA brand name in the mind of ... balancing variety of inputs Balances have to be struck between the external market and internal capabilities of the company; between the company’s inputs into the product and the influences on the...
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THE INFORMAL SECTOR IN SOLID WASTE MANAGEMENT IN DEVELOPING COUNTRIES SUSTAINABILITY EFFECTS OF FORMALISATION CONSIDERING HO CHI MINH CITY – VIETNAM AS AN EXAMPLE
... 11 THE INFORMAL SECTOR IN SOLID WASTE MANAGEMENT IN DEVELOPING COUNTRIES III The informal sector and the informal economy III.1 Definition The term ‘informal sector’ was first introduced by the ... the increased integration of the informal sector into the formal waste management system instead of investing the scarce financial resources in inappropriate high tech solutions Therefore, it ... permissions to carry out their activity without being fully integrated into the formal system (cp CROSS, 1998) The most widespread way of defining the informal sector is a reverse approach: to define...
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Báo cáo " Imperialism of communicative language teaching and possible resistance against it from teachers in Vietnam as an English foreign languages context " doc
... of the tremendous interest in learning the language, so too in many cases CLT has spread not only because of the promotion of the approach by western specialists but also because educators in these ... teaching to more up -to- date ones Communicative Language Teaching is in the list of new ways of teaching Many schools and universities are attempting to employ CLT into syllabus design, examinations, ... teaching, CLT was given top priority All the teachers in the Department had to and still have to adjust themselves to the new tendency Grammar is no more treated as an important part in the classroom...
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Báo cáo khoa học: Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers Implications for the epilepsy seen in the dementia FENIB ppt
... neuroserpin was comparable to that obtained for other serpins, including a1-antitrypsin and a1-antichymotrypsin [19,20] In comparison, the spectrum of Ser52Arg neuroserpin shows an increase in both ... a1-antichymotrypsin The reactive centre loop (red) is inserted into b-sheet A (green), which explains the inactivity as an inhibitor of tPA and the resistance of the reactive loop to cleavage The lower ... recombinant proteins The Ser52Arg mutation was introduced into the cDNA of human neuroserpin in the pQE81L expression vector [6] by a two-step PCR The gene was fully sequenced to ensure that there were...
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Báo cáo " An assessment of healthcare system accessibility of local communities in Yen Chau District, Son La Province " pot
... and minimum time for people in order to move from origin to destination. In fact, the travel time is calculated as the total time to pass all of relief units from origin to ... for academic purposes. The extension uses both vector and raster data. The analysis tool for final purpose is using data in raster format. 3.1.1. Creating the map of origins According to the data interpolation ... identify the need of public services during their life in the particular period. The connections between three components show the travel cost and the efforts in order to travel from origins ...
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Báo cáo khoa học: Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector pot
... weak inhibitor (Ki ẳ 240 lm) [31] Trying to get some insight into the factors that cause the light decay and into the relative importance of L-AMP and other possible inhibitors formed in the course ... using the formula (vCoA-vi) vi vi is the maximum RLU observed in the presence of the indicated inhibitor (L-AMP or L-CoA) and in the absence of CoA; vCoA is the maximum RLU when both inhibitor ... starting the light reaction by injecting a mixture containing LH2 and ATP supplemented with CoA, we observed a marked antagonizing effect of CoA on the inhibitory effect of 5208 L-AMP in Fig the...
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Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt
... ung th in vitro, thấy quercetin làm thoái giáng đột biến p53 - protein, làm ngừng chu kỳ tế bào giai đoạn G1 , ức chế tyrosin - kinase, ngăn chặn hoạt tính protein - ras In vitro, quercetin ức ... Curcumin có nhiều ảnh hởng đến sinh lý bệnh học tế bào ung th: in vitro, curcumin làm ngừng chu kỳ tế bào u, thúc đẩy chết theo chơng trình (apoptosis) Tuy nghiên cứu hạn chế, nhng thấy curcumin ... bào khác nhau, thấy quercetin làm tăng hiệu lực điều trị cisplatin, adriamycin, busulfan, cyclophosphamid làm tế bào ung th giảm đề kháng với gemcitabin topotecan Bromelain Là hỗn hợp protease chứa...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008