... comfort area defined by ASHRAE (Figure 30) As well as the other two cases, cooling is performed as a consequence of an increase in the humidity level, though in this case it is more effective for ... large devices, and heat-exchange between gas mediums require great areas of transference, so they are not used Another system, more cheap and compact, was designed by Dr Pernot and later by Dr ... advantages and disadvantages and indicating and establishing some basis about their design, was developed by Dr John R Watt, who worked for the Research Laboratory of the U.S Navy He built and...
... Glaubitz and Andreas Engel for valuable discussions, and we thank Walter Rosenthal for the cDNA of human ETB We further ´ thank Robert Tampe and Katrin Schulze for their help with SPR analysis ... Switzerland), and 0.1% (w ⁄ v) Triton X-100 Horseradish peroxidase-conjugated T7-tag antibody (Merck Biosciences) was diluted : 5000 and incubated for h with the membrane Washed blots were analyzed ... Homo-oligomerization of rhodopsin-like GPCRs is an increasingly recognized mechanism, and might represent an important platform for the modulation of GPCR activities such as ligand binding, signaling or trafficking...
... selectivity can be increased through ligand dimerization or by screening for conformational-sensitive targeting agents such as affibodies, avimers and nanobodies, as well as intact antibodies and their fragments ... reduced toxicity and enhanced anti-metastatic effects in two different mouse tumour models, emphasizing the advantages of a mechanism-based design for targeted nanocarriers84 Organic nanoparticles ... Box Rational design of nanocarriers for cancer therapy Nanocarriers can offer many advantages over free drugs They: For rapid and effective clinical translation, the nanocarrier should: • • •...
... Kiguchi M, Kanazawa T: A communication means for totally locked-in ALS patients based on changes in cerebral blood volume measured with near-infrared light IEICE Transactions on Information and Systems, ... placement This participant had an awkward position in his wheelchair (See Figure 3(b)) which forced us to position the thermal camera at an angle and distance from the participant that was not consistent ... Murthy and Pavlidis non-invasively measured human breathing using infrared imaging and a statistical methodology based on multinormal distributions, the method of moments, and Jeffreys divergence measure...
... benefit and the aim of our study was to determine whether IL-6 was such a marker An animal model using Sprague Dawley rats was used for this study Many studies have utilized rats as a model for fat ... litter The animals were induced using inhalational halothane anesthesia with a mixture of oxygen Depth of anesthesia was assessed by pedal reflex After each animal was anaesthetized, it was placed ... added to each well and incubated for hours It was then aspirated and washed with a buffer solution times Finally 100 μl of substrate solution was added and protected from light for 30 minutes Then...
... data and edited the manuscript HMC analyzed the data and wrote the manuscript PJW conceived the project and edited the manuscript EG was responsible for the HIV test results and edited the manuscript ... used an overview of newly registered insurances of the main insurance companies as a proxy for employee insurance status several months after conducting the surveys This indirect impact assessment ... companies Statistical analyses Statistical analyses were performed with SPSS version 15.0 for Windows, Chicago: SPSS Inc For significance testing, Chi square and Student's T-test were used for...
... variation, was 0.28% for the DXR-BMD hand and was 0.76% for the DXABMD hand Long-time precision for DXR-BMD based on daily measurement of one hand radiograph was 0.25%, and longtime precision for the ... authors read and approved the final manuscript Acknowledgements The authors thank Anders Strand for technical assistance and for performing the precision studies for the hand bone measurements ... significant loss in hand BMD was seen at years as measured by DXR-BMD (-0.90%) and DXR-MCI (1.18%), but not as measured in the DXA-BMD hand (0.00%) (Figure 1) A significant bone loss was also...
... were anesthetized with isoflurane Left ventricular function was studied just before transplantation and followed-up and weeks later, by echocardiography with an ultrasound machine (HDI 5000 ultrasound ... plane and LV end-diastolic dimension (EDD) and end-systolic dimension (ESD) were measured In addition, the percentage of fractional shortening (FS) was calculated All measurements were performed ... Immunohistochemical studies for CD3, CD8 and CD 20 The mean number of cells positive for CD3 was decreased significantly in SVF transplanted rats compared to controls (p < 0.05; Figure 5) The mean Premaratne...
... increases and promotes collagen matrix formation, angiogenesis, osteoclast/osteoblast activity and bone union [24-26] Increased oxygen tension improves neutrophil ability to kill bacteria Some antibiotics ... Northern New England Cardiovascular Disease Study Group: Mediastinitis and long-term survival after coronary artery bypass graft surgery Ann Thorac Surg 2000, 70:2004-7 Muñoz P, Menasalvas A, Bernaldo ... initially and then guided by culture report and antibiotic susceptibility tests Early debridement, daily antiseptic irrigation and dressing change were performed After the infection was under...
... produced a significant reduction in the primary endpoint, RBC transfusion requirements (a surrogate for blood loss), and significantly reduced the need for massive transfusions (more than 20 units of ... with a second dose as required Treatment with rFVIIa significantly reduced requirements for transfusion of RBCs and other blood products, and there was a marked and significant reduction in International ... sponsor was permitted, and the sponsors did not see the manuscript until it had been accepted for publication JLV has received study grants and honoraria in the past from Novo Nordisk RR has received...
... could not be objectively assessed for patients who were alive for only a few hours Statistical analysis Data are expressed as mean ± standard deviation or as median and range All statistical comparisons ... two-tailed, and P less than 0.05 was considered significant Comparison between the two groups was performed using the WilcoxonMann-Whitney rank sum tests for continuous outcomes (transfusions, ... trial product, as previously described [22] Outcome of therapy was further assessed through requirement for other transfusion products, massive transfusion (defined as more than 20 units of RBCs...
... of CCR5 and CXCR4 for HIV-1 infection can be inhibited by their ligands, RANTES and SDF-1β, respectively [37,38] Some ligands have been used as starting materials to find and develop anti-HIV ... has tyrosine residues accompanied by asparagines, aspartic acids, and glutamic acids in its NTR (see Additional file 1) Therefore, we focused on a formylpeptide receptor, FPRL1, as a novel candidate ... peptide (B) or RANTES for two hours at 37°C (C), and then inoculated with two HIV-1 strains, GUN-7WT (m and l) and HCM342 (h and n), HIV-2 CBL23 strain (n and s), and SIV mndGB-1 strain ( and r) Six...
... identifying data and as such informed consent has been waived and specific ethical approval was not required Hospital identifying data is held encrypted in the CORE database and was not released for this ... data, performed the statistical analysis and drafted the manuscript KMH performed data analysis and helped to draft the manuscript CG, RB, GH, and SW participated in its design and analysis of ... Statistical analysis Continuous data with a near normal distribution are presented as mean and standard deviation and data with a skewed distribution were expressed as median and interquartile range...
... Dr May Khanna, Lanmin Zhai, Cindy Morgan, Dr Vimbai Chikwana, Dr Ann Kimble Hill, Cameron Buchman and Krishna Kishore Mahalinghan for their friendship and support I could not have asked for a better ... 0.5 and 1.0 is an indication of an excellent assay, and a value between and 0.5 is 28 an indication of a poor assay (Zhang et al., 1999) To calculate the Z’ factor measurement, positive and negative ... importance in cancer chemoresistance ALDH3A1 was originally designated as the tumor ALDH, as it was found highly expressed in some human tumors such as hepatoma, lung adenocarcinoma, myeloma, breast...
... students develop and express ideas in another language and translation can help reduce learning anxiety and enhance motivation to learn English Tran Duy Chang-TH1201: this male- student was quite good ... foreign language, and tend to ask the question how an expression is translated in the foreign language and what rules are involved More importantly, the use of translation at the advanced level can ... often use translation as a learning strategy to comprehend, remember, and produce a foreign language Translation has been used by foreign language learners to facilitate language learning for centuries,...
... or ferrous salts, and studied for the performance and the mechanism in heavy metal removal (Kanel et al., 2005; Kanel et al., 2006; Li and Zhang, 2006; Li and Zhang, 2007) Kanel et al (2005, ... iron-based nanoparticles or their subcolloidal particles Iron-based nanoparticles are inexpensive, easily scalable and highly reactive towards a wide array of organic and inorganic pollutants (Zhang, ... affect the efficiency and production throughput of the membrane-based separation process for nanoparticle recovery The identification of dominant fouling mechanism as well as the transition in internal...
... supernatant was carefully removed and the pellet was washed with 500 μl 70% ethanol followed by centrifugation for at 13, 000 × g The washing step was repeated once and the supernatant was carefully ... model organism is an important tool to help us advance our knowledge in studying human disease The so-called “model organisms” are the organisms that are cost less in purchasing and feeding, and have ... the plasmid were selected for the purification 2.3.4 Purification of plasmid DNA QIAGEN plasmid mini (for high copy plasmid) or midi (for low copy plasmid) (QIAGEN GmbH, Germany) were used for...
... resulting proteins were assessed by SDS, nondenaturing and transverse urea gradient PAGE, and activity was assessed against tPA [6] Complex formation assays Wild-type and Ser52Arg neuroserpin ... neuroserpin and tPA Ser52Arg neuroserpin is inactive asan inhibitor of tPA Wild-type neuroserpin forms complexes with tPA with a stoichiometry of inhibition of and an association rate constant (kass) ... polymer formation and Tm [19], and thus it was unusual to find that the Tm was higher than that of the less severe Ser49Pro neuroserpin The overall structure of Ser52Arg neuroserpin was therefore assessed...
... conclude that mammalian QR and the 20S proteasome not form a protein complex, as proposed by others [39] Unfortunately, no explanation for the copurification of QR and the 20S proteasome is provided ... NQO2, a homologue of NQO1, was shown to prevent transcription factors from being degraded as well [39] Human QR was described for the first time in 1961 asan unknown mammalian cytosolic FAD-dependent ... of human NQO1, is physically associated with the 20S proteasome [34] Using the 20S proteasome and recombinant Lot6p, several biochemical issues revolving around the stoichiometry and importance...