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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... which exponential accumulation plateaus Using 30 PCR cycles, the products of glyceraldehyde -3- phosphate dehydrogenase (GAPDH) and c- myc amplification were all within the linear phase of the reaction ... pepstatin), containing [c- 33 P]ATP (speci c activity 2500 CiỈmmol)1, Amersham Pharmacia Biotech) Samples were then incubated for h at 37 C, pelleted by centrifugation at 14 000 g and the resulting ... of the reaction products obtained using lL of the RT products after 30 cycles of PCR amplification The lower part of panel A, and panels B, C report the expression of c- myc mRNA levels detected...
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Tài liệu Making the Right Moves A Practical Guide to Scientifıc Management for Postdocs and New Faculty doc
... typically a medical school and hospitals; outpatient centers; and, in many cases, schools of nursing, pharmacy, and other allied health professions Because much of the teaching conducted under the ... laboratories The course in scientific management, which focused on these competencies, received an exceptionally enthusiastic response In the postcourse focus groups and surveys, participants said ... them to completion Laura Bonetta, science writer and course coordinator, and Patricia Davenport (HHMI) were crucial to shaping the content of the manual and managing the editorial process The following...
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The mediating role of trust in the relationship between key account management programs and commitment a dealer perspective luận văn thạc sĩ
... was conducted to test the hypotheses and research model from perspective of dealers who have a voice in buying decision process 3. 6 .3 Collecting data Based on the principles of choosing the scope ... characteristics of the original variables The components extracted could represent for a 33 discriminant facets of the studied constructs The extracted components then could be used for further analysis ... really concern about the installation and maintenance as technology is very advanced, and becomes obsolete quickly Moreover, the switching cost is quite high In such uncertainty, to gain confidence...
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Land-based marine pollution and the Arctic - polarities between principles and practice
... Services Canada, 1999), text available at the Arctic Council website at http://arctic-council.usgs.gov Land-based marine pollution and the Arctic 1 93 Arctic states are in the longer term called ... over the adequacy of financial and human resource commitments to environmental protection, and the effectiveness of compliance and enforcement This chapter examines the tensions between the principles ... Affairs Canada, 1996), p 4, section The Declaration is available at the Arctic Council website at http://arctic-council.usgs.gov Land-based marine pollution and the Arctic 191 a fully referenced...
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Tài liệu Thi thử đại học Tiếng Anh 2009_Lương Thế Vinh HN (Có key) pptx
... A 25 C 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 A D A C C D A A C B B D B A D B B A D B D B C C D ... when the Sun, Moon, and Earth lie at the apexes of a triangular configuration and the pull of the Sun and Moon are opposed, the moderate tidal movements called neap tides occur Then the difference ... tides? A Seasonal changes in the weather B The triangular arrangment of the Earth, Sun, and Moon C The Earth s movement around the Sun D The gravitational pull of the Sun and the Moon when nearly...
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Tài liệu The Go Big Now Guide - 5 Steps to Make the Law of Attraction Key Work for You docx
... reality and all you have to is literally CHANGE THE CHANNEL and CHANGE YOUR ORDER The good news is that because you are already using the Law of Attraction Key and the Steps of the Law of Attraction ... plays music you hate, you sit there complaining about the music and focusing on how much you wish you were listening to something different or you change the channel? You Change The Channel! If ... what they desire, but they can’t figure out what their blocks are They can’t figure out what they really believe and focus on all day long Because the thing about the thoughts you think most of the...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... (NSC92- 231 1-B-001) from the National Science Council, Taiwan, R.O .C and the theme project of Academia Sinica, Taipei, Taiwan, R.O .C 39 65 Staphylococcal nuclease refolding Z Su et al References ... the wild-type protein and the mutants K 133 A, E142O, W140A and W140O are shown in Fig 3, with their thermodynamic parameters summarized in Table The calorimetric DHcal values 39 61 Staphylococcal ... protein can be determined by its far-UV CD spectrum as the sum of fractional multiples of the reference spectra for each structural type Figure 1A shows the CD spectra of W140A, E142O and K 133 A There...
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Tài liệu Báo cáo khoa học: A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana doc
... Where, kcatTS and kcatTS are the TS catalytic constant in the absence and presence of a saturating concentration of AdoMet, respectively K1K2 is the product of the binding constants for the association ... CGS with respect to Phser (Eqn 3) kapp catCGS ¼ kcatCGS KCys ỵ mCGS Cys 2ị KPhser mCGS ẵP 1ỵ Pi ẳ i KCys KiCGS ỵ Â mCGSÃ Cys ! 3 Where, [Pi] is the concentration of Pi Pi competitively ... ẵPhser mCGS 1ị app Where, [CGS] is the CGS monomer concentration, kcatCGS is the apparent catalytic constant for CGS (Eqn 2) and app KmCGS is the apparent Michaelis–Menten constant for CGS with...
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Health and Work of the Elderly: Subjective Health Measures, Reporting Errors and the Endogenous Relationship between Health and Work doc
... routes and the income streams attached to each of these options The worker takes into account his or her present health condition and will recognise the effect of work choices on current and future ... the outcome of the Hopkins Symptom Checklist (HSCL) The HSCL is a validated objective test of general health used in the medical sciences to assess the psycho-neurotic and somatic pathology of ... specifications The naïve specification (I) gives the smallest effects, for all labour markets state dummies In specification II (standard random effects approach) the size of the effect for DI and...
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Báo cáo khoa học: "Recognition of the Coherence Relation between Te-linked Clauses" potx
... types (distinct subjects) 2nd clause ACT GO BECOME ACT Contrast BE Ist clause I BECOME I BE Concession Cause I GO Contrast Cause Circum Circum Contrast Cause Cause Circum Contrast Circum movements ... [x ACT]2 B Y ix ACT]I ix A C T O N YL B U T [y N O T B E C O M E 1st c l a u s e [ BECOME n d clause Circum TempSeq TempSeq Cause Circum Cause Circum Cause Additive Cause Circum Table 3: The combinations ... which fix the temporal boundary, then Temporal Sequence; otherwise, Circumstance • I(BE,BECOME) If the second event is psychological, then Cause-Effect; otherwise, Circumstance • I(BE,BE) If the...
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Livestock and Climate Change What if the key actors in climate change are…cows, pigs, and chickens? docx
... linked to the consumption of livestock products Full accounting of GHGs attributable to livestock products would cover portions of the construction and operation of pharmaceutical and medical industries ... 25-percent reduction in livestock products worldwide could be achieved between now and 2017, the end of the commitment period to be discussed at the United Nations’ climate conference in Copenhagen ... which are expected to occur with increasing frequency and intensity worldwide A second incentive stems from the likelihood, once the current economic crisis is resolved, that demand for oil will...
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The Harvard Classics Volume 38, by Various Copyright laws are changing all over the world. Be sure to check the copyright laws for your country before downloading or redistributing this pdf
... attendants, and externals cooperate." THE OATH OF HIPPOCRATES I swear by Apollo the physician and AEsculapius, and Health, and All-heal, and all the gods and goddesses, that, according to my ability and ... Rohan and de Laval, because they were the seigneurs of that country, and by their help the country people would beat back the enemy, and keep them from landing Having heard this, the King sent these ... voluntary act of mischief and corruption; and, further, from the seduction of females or males, of freemen and slaves Whatever, in connection with my professional practice, or not in connection with...
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Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc
... GCTCTAGAGTTTAAACATAGTCAATGAACTTGTACGC AGGAAGGCCGGCAAATGGC TTCACGTGAGATAAGCTCCC ACGGTTTCGGTGAAGCCAG ACAATTAATTAACAGTATGTACGAGCGATGCG ACAAAAGCTTGGCGCAAATCATAGCTTCTTG GACTAGTTTAAACGGATCGACGAGTTCGACGC ... GACTAGTTTAAACGGATCGACGAGTTCGACGC GACTAGTTTAAACGAGGCACTGTGACCAGATGC CGTTCTGGAGCAACCTTCG GGTCGAGGAAGTACGTGAC GCTCTAGAGCAACCGTCCGAAATATTATAAA GCTCTAGATCTCATAAAAATGTATCCTAAATCAAATATC ppsE res 1966 FEBS Journal ... (arrow) and DIM B (arrowheads) are indicated (C) TLC analysis of glycolipids extracted from M tuberculosis H37Rv, H37Rv:pPET1, and PMM74:pPET1 Lipids were dissolved in CHCl3 and run in CHCl3 ⁄ CH3OH...
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Buying a new car? Check the warranty before you sign… doc
... much will the servicing costs be? (Compare them to other garages in your area) • How much leeway is there if I cannot get the car serviced in accordance with the approved servicing schedule? • ... free to get your car serviced anywhere in the UK and still benefit from the manufacturer’s new car warranty, as long as the service is carried out to the car manufacturer’s recommendations, even ... repairer services and maintains your vehicle in accordance with the manufacturer’s recommendations.’ ‘This warranty is dependent upon the manufacturer’s recommended servicing being carried out...
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Báo cáo khoa học: Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-b gene promoter docx
... virus-infected cells can be expressed and activate transcription in insect cells, and the p300 and CBP coactivators have distinct and speci c effects on their transcriptional activity Transcription factors ... Arbitrary Units 3. 0 35 Vector C P31x4CAT in S2 cells 40 -+ -+ Vector hp300 -+ -+ 30 25 20 15 10 ATF-2 /c- Jun mCBP hp300/mCBP Vector + + + + NF-κB hp300 mCBP hp300/mCBP Fig Effects of hp300 and mCBP expression ... explored the mechanism underlying this synergy by coexpressing these transcription factors and the p300/CBP coactivators in S2 cells (Table 1) ATF-2 /c- Jun, IRF -3 and IRF-7 each stimulated the P 431 ·3CAT...
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Báo cáo khoa học: Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human aB-crystallin docx
... small 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 heat-shock protein alphaB-crystallin J Biol Chem 274, 30 190– 30 195 Clark, J.I & Muchowski, P.J (2000) Small heat-shock proteins and their potential ... 16 .3 : CS [d, CS alone; ,, HSP 16 .3 : CS (5 : 1); j, HSP 16 .3 : CS (5 : 1) + ATP; s, HSP 16 .3 : CS (10 : 1); , HSP 16 .3 : CS (10 : 1) + ATP] (C) Control for the effect of ATP on the molecular chaperone ... shock at 48 C (Fig 2B ,C) In vitro chaperone activity of MTB HSP 16 .3 and aB-crystallin In Fig 3, we observed the effects of different concentrations of MTB HSP 16 .3 in the presence and absence...
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Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt
... (5¢-ccctacggaaacaac gatcgctgcgactacatgggta) and P9 (5¢-tacccatgtagtcgcagcgatcg ttgtttccgtaggg), and P10 (5¢-tgaagctggtgaattatcgattggtggagaa ggg) and P11 (5¢-cccttctccaccaatcgataattcaccagcttca), respectively ... mutations C6 0F and C4 73A were introduced using primers P4 (5¢-atgtagccattgtatttgaaaatgagcaact) and P5 (5¢- agttgctcattttcaaatacaatggctacat), and P6 (5¢- gaacagc cgtatttggccgcttattttgtatc) and P7 ... gatacaaaataagcggccaaa tacggctgttc), respectively, to give pJZ12 In the same manner, the plasmid pJZ11, encoding the mutations C3 31 A and C3 76S, was generated using primers P8 (5¢-ccctacggaaacaac...
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Báo cáo khoa học: On the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoAOn the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoA doc
... by the Croatian Ministry of Science (project 0980982 933 -2 937 ) and the EC (FP6 contract 0 437 49) Work in Marburg was supported by the Max-Planck Society, Deutsche Forschungsgemeinschaft and the FEBS ... was 37 0 : Acrylyl-CoA reductase activity was measured with propionyl-CoA and ferricenium hexafluorophosphate as electron acceptor [26] The concentrations of CoASH, acetyl-CoA and glutaconyl-CoA ... opposed to Kconc., for convenience H R O H Ka >> Kb ~ R=CH2CO2H lactyl-CoA ( 1c) FEBS Journal 277 (2010) 1 738 –1746 ª 2010 The Authors Journal compilation ª 2010 FEBS Kconc = SCoA R=CH(CH3)2 2-hydroxyglutaryl-CoA...
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